K. A. Smith
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View article: Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator
Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator Open
Insulin action on the skeleton is essential for bone development and whole-body energy metabolism, however a global view of signaling in this tissue is lacking. Furthermore, whether there are signaling differences that drive the gene-speci…
View article: The open and closed case for Class I HDACs in cardiac development
The open and closed case for Class I HDACs in cardiac development Open
Gene expression in cardiac development is regulated through complex epigenetic mechanisms. Histone deacetylases (HDACs) are one of the many layers of epigenetic modulation, whereby they remove acetylation marks on histone tails, prompting …
View article: Model-informed drug development in rare diseases
Model-informed drug development in rare diseases Open
Model-informed drug development (MIDD) approaches maximise and connect information obtained on a drug during development, allowing better characterisation of its risk: benefit profile. MIDD is especially useful for rare diseases with few p…
View article: Professional learning in education: policy and practice in Wales since devolution
Professional learning in education: policy and practice in Wales since devolution Open
In the 25 years since devolution in Wales, professional learning has changed significantly. This article considers the development of Welsh Government initiatives over the last two decades and explores where they might be placed on a conti…
View article: Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α
Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α Open
Protein phosphatase 2A (PP2A) regulatory subunit B55α has been implicated in the transcriptional regulation of cardiac growth and fibrosis by suppressing HDAC5/MEF2 signalling in cardiomyocytes. We created and characterised two mouse model…
View article: Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α
Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α Open
1. Abstract Protein phosphatase 2A (PP2A) regulatory subunit B55α has been implicated in the transcriptional regulation of cardiac growth and fibrosis by suppressing HDAC5/MEF2 signalling in cardiomyocytes. We created and characterised two…
View article: Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish
Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish Open
Dilated cardiomyopathy (DCM) is a common heart muscle disorder that frequently leads to heart failure, arrhythmias, and death. While DCM is often heritable, disease-causing mutations are identified in only ~30% of cases. In a forward genet…
View article: Examining the long-term effects of traumatic brain injury on fear extinction in male rats
Examining the long-term effects of traumatic brain injury on fear extinction in male rats Open
There is a strong association between traumatic brain injuries (TBIs) and the development of psychiatric disorders, including post-traumatic stress disorder (PTSD). Exposure-based therapy is a first-line intervention for individuals who su…
View article: Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart
Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart Open
Transmembrane protein 161b (Tmem161b) was recently identified in multiple high-through-put phenotypic screens, including in fly, zebrafish, and mouse. In zebrafish, Tmem161b was identified as an essential regulator of cardiac rhythm. In mo…
View article: Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development Open
During development, the lymphatic vasculature forms as a second network derived chiefly from blood vessels. The transdifferentiation of embryonic venous endothelial cells (VECs) into lymphatic endothelial cells (LECs) is a key step in this…
View article: TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system
TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system Open
Sonic hedgehog signaling regulates processes of embryonic development across multiple tissues, yet factors regulating context-specific Shh signaling remain poorly understood. Exome sequencing of families with polymicrogyria (disordered cor…
View article: ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma
ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma Open
The nucleoporin (NUP) ELYS, encoded by AHCTF1 , is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using both larval and adult zebrafish models of hepatocellular carcinoma (HCC), in which the expr…
View article: Author response: ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma
Author response: ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The nucleoporin (NUP) …
View article: Virtual opioid agonist treatment: Alberta’s virtual opioid dependency program and outcomes
Virtual opioid agonist treatment: Alberta’s virtual opioid dependency program and outcomes Open
Background Virtually delivered healthcare (telehealth, telemedicine) has the potential to reduce gaps in access to opioid agonist therapy (OAT). Barriers to accessing OAT such as lack of transportation, in-person induction requirements, em…
View article: Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of<i>npas4l</i>and<i>etv2</i>
Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of<i>npas4l</i>and<i>etv2</i> Open
The endocardium plays important roles in the development and function of the vertebrate heart; however, few molecular markers of this tissue have been identified and little is known about what regulates its differentiation. Here, we descri…
View article: HOPX governs a molecular and physiological switch between cardiomyocyte progenitor and maturation gene programs
HOPX governs a molecular and physiological switch between cardiomyocyte progenitor and maturation gene programs Open
SUMMARY This study establishes the homeodomain only protein, HOPX, as a determinant controlling the molecular switch between cardiomyocyte progenitor and maturation gene programs. Time-course single-cell gene expression with genome-wide fo…
View article: Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development
Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development Open
During development, the lymphatic vasculature forms as a second, new vascular network derived from blood vessels. The transdifferentiation of embryonic venous endothelial cells (VECs) into lymphatic endothelial cells (LECs) is the first st…
View article: Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle
Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle Open
The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by analyzing two vertebrate systems, mouse and zebrafish. In …
View article: Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress
Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress Open
The nucleoporin ELYS, encoded by AHCTF1 , is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using a zebrafish model of hepatocellular carcinoma, in which the expression of an inducible mutant kra…
View article: Getting to the Heart of Left–Right Asymmetry: Contributions from the Zebrafish Model
Getting to the Heart of Left–Right Asymmetry: Contributions from the Zebrafish Model Open
The heart is laterally asymmetric. Not only is it positioned on the left side of the body but the organ itself is asymmetric. This patterning occurs across scales: at the organism level, through left–right axis patterning; at the organ lev…
View article: The zebrafish<i>grime</i>mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm
The zebrafish<i>grime</i>mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm Open
Significance The heart initiates rhythmic contractions early during development. A unique zebrafish mutant with specific cardiac arrhythmia phenotypes was identified and mutation of the uncharacterized tmem161b gene shown to be causative. …
View article: Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle
Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle Open
Summary The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by analyzing two vertebrate systems: mouse and zebraf…
View article: Practical considerations in prevention and treatment of venous thromboembolism in hospitalized patients with COVID-19
Practical considerations in prevention and treatment of venous thromboembolism in hospitalized patients with COVID-19 Open
Purpose There are increasing reports in the literature of high rates of coagulopathy and venous thromboembolism (VTE) among hospitalized patients with coronavirus disease 2019 (COVID-19). Understanding of these abnormalities is continually…
View article: Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo
Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo Open
The lymphatic vasculature develops primarily from pre-existing veins. A pool of lymphatic endothelial cells (LECs) first sprout from cardinal veins followed by migration and proliferation to colonise embryonic tissues. While much is known …
View article: Image Seeking and Use by Graduate History Students: An Exploratory Study
Image Seeking and Use by Graduate History Students: An Exploratory Study Open
This exploratory study examines the image seeking and use behaviors of graduate history students. Informal interviews with six graduate students answered the primary questions directing this study: What role do images play for graduate his…
View article: Pediatric Obesity Interventions in Racial and Ethnic Minorities: A Systematic Review
Pediatric Obesity Interventions in Racial and Ethnic Minorities: A Systematic Review Open
Background: The prevalence of childhood obesity has increased dramatically in the United States, disproportionately afflicting racial and ethnic minorities and producing lifelong health consequences. Various lifestyle and pharmacologic obe…