Ka Wan Li
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View article: Correction: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Correction: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
View article: Correction: Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome
Correction: Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome Open
View article: Pembrolizumab with trastuzumab and chemotherapy for HER2-positive advanced gastric cancer: health-related quality-of-life analysis from the randomized KEYNOTE-811 trial
Pembrolizumab with trastuzumab and chemotherapy for HER2-positive advanced gastric cancer: health-related quality-of-life analysis from the randomized KEYNOTE-811 trial Open
View article: Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome
Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome Open
View article: A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia
A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia Open
Summary Schizophrenia (SCZ) is a complex psychiatric disorder with a diverse genetic landscape, involving common regulatory variants, rare protein-coding mutations, structural genomic rearrangements, and transcriptional dysregulation. A cr…
View article: Author response: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Author response: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
View article: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
Dense core vesicles (DCVs) transport and release various neuropeptides and neurotrophins that control diverse brain functions, but the DCV secretory pathway remains poorly understood. Here, we tested a prediction emerging from invertebrate…
View article: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
Dense core vesicles (DCVs) transport and release various neuropeptides and neurotrophins that control diverse brain functions, but the DCV secretory pathway remains poorly understood. Here, we tested a prediction emerging from invertebrate…
View article: Author response: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Author response: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
View article: Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s disease
Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s disease Open
Alzheimer's Disease (AD) is an incurable and debilitating progressive, neurodegenerative disorder which is the leading cause of dementia worldwide. Neuropathologically, AD is characterized by the accumulation of Aβ amyloid plaques in the m…
View article: Type I TARPs regulate Kv7.2 potassium channels and susceptibility to seizures
Type I TARPs regulate Kv7.2 potassium channels and susceptibility to seizures Open
Summary The M-current is a low-threshold potassium current that modulates neuronal excitability and suppresses repetitive firing. However, the mechanisms regulating M-channel function remain unclear. We identified type I Transmembrane AMPA…
View article: 23O A randomized, phase III, double-blind study of chemoradiotherapy with or without pembrolizumab in patients with high-risk, locally advanced, cervical cancer (KEYNOTE-A18/ENGOT-cx11/GOG-3047): Results for patients enrolled in Asia
23O A randomized, phase III, double-blind study of chemoradiotherapy with or without pembrolizumab in patients with high-risk, locally advanced, cervical cancer (KEYNOTE-A18/ENGOT-cx11/GOG-3047): Results for patients enrolled in Asia Open
In the global, randomized, phase 3 ENGOT-cx11/GOG-3047/KEYNOTE-A18 (NCT04221945) study, pembrolizumab (pembro) + concurrent chemoradiotherapy (CCRT) showed a statistically significant improvement over placebo (pbo) + CCRT in PFS (median PF…
View article: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
Dense core vesicles (DCVs) transport and release various neuropeptides and neurotrophins that control diverse brain functions, but the DCV secretory pathway remains poorly understood. Here, we tested a prediction emerging from invertebrate…
View article: Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis Open
Dense core vesicles (DCVs) transport and release various neuropeptides and neurotrophins that control diverse brain functions, but the DCV secretory pathway remains poorly understood. Here, we tested a prediction emerging from invertebrate…
View article: Multimodal beneficial effects of BNN27, a Nerve Growth Factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s Disease
Multimodal beneficial effects of BNN27, a Nerve Growth Factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s Disease Open
Alzheimer’s Disease (AD) is an incurable and debilitating progressive, neurodegenerative disorder which is the leading cause of dementia worldwide. Neuropathologically, AD is characterized by the accumulation of Aβ amyloid plaques in the m…
View article: Rab10 regulates neuropeptide release by maintaining Ca <sup>2+</sup> homeostasis and protein synthesis
Rab10 regulates neuropeptide release by maintaining Ca <sup>2+</sup> homeostasis and protein synthesis Open
Dense core vesicles (DCVs) transport and release various neuropeptides and neurotrophins that control diverse brain functions, but the DCV secretory pathway remains poorly understood. Here, we tested a prediction emerging from invertebrate…
View article: Brain Region Differences in α1- and α5-Subunit-Containing GABAA Receptor Proteomes Revealed with Affinity Purification and Blue Native PAGE Proteomics
Brain Region Differences in α1- and α5-Subunit-Containing GABAA Receptor Proteomes Revealed with Affinity Purification and Blue Native PAGE Proteomics Open
GABAA receptors are the major inhibitory receptors in the brain. They are hetero-pentamers with a composition of predominantly two α, two β, and one γ or δ subunit. Of the six α subunit genes, the α5 subunit displays a limited spatial expr…
View article: The proteomic profile of Von Economo neurons supports their selective vulnerability in bvFTD
The proteomic profile of Von Economo neurons supports their selective vulnerability in bvFTD Open
Background Von Economo neurons (VENs) are long‐range projection neurons embedded in Layer 5 of the anterior cingulate gyrus (ACC) and frontoinsular cortex. VENs are selectively vulnerable in a number of diseases, most notably in those asso…
View article: Full complement activation is associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease.
Full complement activation is associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease. Open
Background Alzheimer’s disease is the most common form of dementia and mainly characterized by the accumulation the amyloid β (Aβ) peptide in the parenchyma and often around the blood vessels of the brain. The accumulation of Aβ in vessels…
View article: Proteomic profiling of aging brains identifies key proteins by which cognitively healthy centenarians defy their age by decades
Proteomic profiling of aging brains identifies key proteins by which cognitively healthy centenarians defy their age by decades Open
Some individuals reach extreme ages without any signs of cognitive decline. Here, we show that based on key proteins, cognitively healthy centenarians have a biologically younger brain. We compared the brain proteomic signatures of 58 self…
View article: 1511O Pembrolizumab plus trastuzumab and chemotherapy for HER2+ metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma: Survival results from the phase III, randomized, double-blind, placebo-controlled KEYNOTE-811 study
1511O Pembrolizumab plus trastuzumab and chemotherapy for HER2+ metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma: Survival results from the phase III, randomized, double-blind, placebo-controlled KEYNOTE-811 study Open
View article: LBA38 Pembrolizumab plus chemoradiotherapy for high-risk locally advanced cervical cancer: A randomized, double-blind, phase III ENGOT-cx11/GOG-3047/KEYNOTE-A18 study
LBA38 Pembrolizumab plus chemoradiotherapy for high-risk locally advanced cervical cancer: A randomized, double-blind, phase III ENGOT-cx11/GOG-3047/KEYNOTE-A18 study Open
View article: Succinate mediates inflammation-induced adrenocortical dysfunction
Succinate mediates inflammation-induced adrenocortical dysfunction Open
The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, s…
View article: Editorial: Synaptic plasticity and dysfunction, friend or foe?
Editorial: Synaptic plasticity and dysfunction, friend or foe? Open
EDITORIAL article Front. Synaptic Neurosci., 03 May 2023 Volume 15 - 2023 | https://doi.org/10.3389/fnsyn.2023.1204605
View article: Author response: Succinate mediates inflammation-induced adrenocortical dysfunction
Author response: Succinate mediates inflammation-induced adrenocortical dysfunction Open
View article: Suspension TRAPping Filter (sTRAP) Sample Preparation for Quantitative Proteomics in the Low µg Input Range Using a Plasmid DNA Micro-Spin Column: Analysis of the Hippocampus from the 5xFAD Alzheimer’s Disease Mouse Model
Suspension TRAPping Filter (sTRAP) Sample Preparation for Quantitative Proteomics in the Low µg Input Range Using a Plasmid DNA Micro-Spin Column: Analysis of the Hippocampus from the 5xFAD Alzheimer’s Disease Mouse Model Open
Suspension TRAPping filter (sTRAP) is an attractive sample preparation method for proteomics studies. The sTRAP protocol uses 5% SDS that maximizes protein solubilization. Proteins are trapped on a borosilicate glass membrane filter, where…
View article: Blue Native PAGE–Antibody Shift in Conjunction with Mass Spectrometry to Reveal Protein Subcomplexes: Detection of a Cerebellar α1/α6-Subunits Containing γ-Aminobutyric Acid Type A Receptor Subtype
Blue Native PAGE–Antibody Shift in Conjunction with Mass Spectrometry to Reveal Protein Subcomplexes: Detection of a Cerebellar α1/α6-Subunits Containing γ-Aminobutyric Acid Type A Receptor Subtype Open
The pentameric γ-Aminobutyric acid type A receptors (GABAARs) are ligand-gated ion channels that mediate the majority of inhibitory neurotransmission in the brain. In the cerebellum, the two main receptor subtypes are the 2α1/2β/γ and 2α6/…
View article: Protein disulfide isomerases as CSF biomarkers for the neuronal response to tau pathology
Protein disulfide isomerases as CSF biomarkers for the neuronal response to tau pathology Open
INTRODUCTION Cerebrospinal fluid (CSF) biomarkers for specific cellular disease processes are lacking for tauopathies. In this translational study we aimed to identify CSF biomarkers reflecting early tau pathology‐associated unfolded prote…
View article: Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition
Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition Open
Dysregulated extracellular vesicle (EV) release has been implicated in various pathologies, including cancer, neurodegenerative disease and osteoarthritis. Despite clear therapeutic potential, drug screening for EV release modulators has y…
View article: Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders Open