Kwok‐Yung Yuen
YOU?
Author Swipe
View article: Avian Influenza Virus A(H5N1) Genotype D1.1 Is Better Adapted to Human Nasal and Airway Organoids Than Genotype B3.13
Avian Influenza Virus A(H5N1) Genotype D1.1 Is Better Adapted to Human Nasal and Airway Organoids Than Genotype B3.13 Open
Three critically ill or fatal avian influenza A(H5N1) human infections have been reported in North America since November 2024. Notably, all were infected with genotype D1.1 instead of B3.13, the dominant genotype before November 2024. Her…
View article: Comparative study of the impact of adjuvant trastuzumab and its biosimilars on cardiac function in HER2-positive early breast cancer patients: a single-center study
Comparative study of the impact of adjuvant trastuzumab and its biosimilars on cardiac function in HER2-positive early breast cancer patients: a single-center study Open
Introduction Two trastuzumab biosimilars have been introduced into the local public healthcare system since April 2021 as alternatives for treatment of human epidermal growth factor receptor (HER2) positive breast cancer. While their oncol…
View article: Comparative Evaluation and Performance of Large Language Models in Clinical Infection Control Scenarios: A Benchmark Study
Comparative Evaluation and Performance of Large Language Models in Clinical Infection Control Scenarios: A Benchmark Study Open
Background: Infection prevention and control (IPC) in hospitals relies heavily on infection control nurses (ICNs) who manage complex consultations to prevent and control infections. This study evaluated large language models (LLMs) as arti…
View article: Enhanced replication of a contemporary avian influenza A H9N2 virus in human respiratory organoids
Enhanced replication of a contemporary avian influenza A H9N2 virus in human respiratory organoids Open
H9N2 is currently the second most common avian influenza A virus subtype infecting humans. Monitoring viral phenotypic and genotypic adaptation to humans is crucial for risk assessment. Here, we compared the replication of an H9N2 human is…
View article: Comparative performance of a commercial and in-house Mp1p antigen-detecting enzyme immunoassay for the rapid diagnosis of talaromycosis
Comparative performance of a commercial and in-house Mp1p antigen-detecting enzyme immunoassay for the rapid diagnosis of talaromycosis Open
Background Several antigen-detection assays have been developed for the rapid diagnosis of talaromycosis , but their utility has been limited by a lack of commercial options. The aim of this study was to perform a head-to-head comparison o…
View article: Author Correction: Identification and characterization of GLDC as host susceptibility gene to severe influenza
Author Correction: Identification and characterization of GLDC as host susceptibility gene to severe influenza Open
[Image: see text]
View article: Recent Advances in the Diagnosis of Talaromycosis
Recent Advances in the Diagnosis of Talaromycosis Open
Talaromycosis is an invasive fungal disease endemic to Southeast Asia. While culture is essential in identification, susceptibility testing, and typing, the low sensitivity and long turnaround times limit its clinical utility. Several prom…
View article: Best practices and practical strategies for co-designing virtual reality with Indigenous peoples: A scoping review protocol
Best practices and practical strategies for co-designing virtual reality with Indigenous peoples: A scoping review protocol Open
Virtual reality (VR) is gaining traction in healthcare, education, and cultural sectors, from simulations in medical education to immersive museum experiences. Recently, VR has emerged as a powerful tool for Indigenous cultural preservatio…
View article: Dual-Genotype <i>Orientia tsutsugamushi</i> Infections, Hainan Island, China, 2023
Dual-Genotype <i>Orientia tsutsugamushi</i> Infections, Hainan Island, China, 2023 Open
We report 3 cases of dual-genotype Orientia tsutsugamushi infection in Hainan Island, China. Patients exhibited diverse clinical manifestations, including afebrile illness and multiorgan involvement, highlighting the complexity associated …
View article: BRD9 functions as an HIV-1 latency regulatory factor
BRD9 functions as an HIV-1 latency regulatory factor Open
A major challenge for HIV type 1 (HIV-1) cure is the presence of viral latent reservoirs. The “Shock & Kill” strategy involves the combined use of latency reversal agents (LRA) and antiretroviral treatment (ART) to reactivate HIV-1 latent …
View article: Understanding intentions to use a multi-component supported self-management platform for long COVID-19: a mixed-methods evaluation in Hong Kong
Understanding intentions to use a multi-component supported self-management platform for long COVID-19: a mixed-methods evaluation in Hong Kong Open
A culturally appropriate, multi-component self-management platform was developed to facilitate Long COVID-19 recovery in Hong Kong, comprising a smartphone application, a website, and a customer relationship management (CRM)-based messagin…
View article: Oncocytes in Thyroid Aspirates—Implications of Clinical Parameters and Cytologic Diagnosis
Oncocytes in Thyroid Aspirates—Implications of Clinical Parameters and Cytologic Diagnosis Open
Importance The clinical significance of oncocytes in thyroid aspirate is uncertain, leading to inconsistent and possible over-treatment. Objective To determine the predictive significance of clinico-radiological parameters and cytologic di…
View article: Kaposi sarcoma herpesvirus (KSHV) inflammatory cytokine syndrome (KICS): a case study
Kaposi sarcoma herpesvirus (KSHV) inflammatory cytokine syndrome (KICS): a case study Open
Our case report underscores the critical need for heightened awareness and recognition of KICS, given its rarity and unique clinical characteristics. By elucidating the complex interrelationships between Kaposi sarcoma, inflammatory cytoki…
View article: Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models
Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models Open
The highly pathogenic avian influenza (HPAI) H5N1 virus has been endemic in aquatic birds since 1997, causing outbreaks in domestic poultry and occasional human infections worldwide. Recently, the cross-species transmission of a new reasso…
View article: Generative Artificial Intelligence Models in Clinical Infectious Disease Consultations: A Cross-Sectional Analysis Among Specialists and Resident Trainees
Generative Artificial Intelligence Models in Clinical Infectious Disease Consultations: A Cross-Sectional Analysis Among Specialists and Resident Trainees Open
Background/Objectives: The potential of generative artificial intelligence (GenAI) to augment clinical consultation services in clinical microbiology and infectious diseases (ID) is being evaluated. Methods: This cross-sectional study eval…
View article: Patient-centric analysis of Orientia tsutsugamushi spatial diversity patterns across Hainan Island, China
Patient-centric analysis of Orientia tsutsugamushi spatial diversity patterns across Hainan Island, China Open
Background Scrub typhus, traditionally caused by Orientia tsutsugamushi , is a re-emerging public health concern within the Tsutsugamushi Triangle. Despite growing awareness, prevention strategies remain inadequate on Hainan Island, China,…
View article: Facilitators, barriers, and impacts to implementing dementia care training for staff in long-term care settings by using fully immersive virtual reality: a scoping review
Facilitators, barriers, and impacts to implementing dementia care training for staff in long-term care settings by using fully immersive virtual reality: a scoping review Open
Background The increasing ageing population highlights the urgent need for enhanced dementia care training among formal caregivers. Virtual reality technology has emerged as an innovative tool to address this challenge, offering potential …
View article: Prevalence of Rocahepevirus ratti (rat hepatitis E virus) in humans and rats in China
Prevalence of Rocahepevirus ratti (rat hepatitis E virus) in humans and rats in China Open
Building on our previous work finding that Rocahepevirus ratti (rHEV) is a novel cause of sporadic viral hepatitis in humans, we studied rHEV exposures in humans from various epidemiological settings. We found intermittent exposure to rat …
View article: Viral load detection on surgical mask worn by patients with acute respiratory virus infection
Viral load detection on surgical mask worn by patients with acute respiratory virus infection Open
Objectives: This study investigated viral load (VL) in surgical mask worn by adult patients infected with respiratory viruses. Methods: Surgical masks were dissected into six pieces: inner (N1) and outer (N2) layers at the nose, inner (M1)…
View article: Time is now: Preparing for the next pandemic
Time is now: Preparing for the next pandemic Open
At the BIOHK2024, held on September 11–14, 2024, the roundtable discussion titled “Time is now: Preparing for the next pandemic,” brought together Professors Jun Liu, George Fu Gao, Kwok-Yung Yuen, Lit Man Leo Poon, and Nan Song. They expl…
View article: Kaposi Sarcoma Herpesvirus (KSHV) inflammatory cytokine syndrome (KICS): A case study
Kaposi Sarcoma Herpesvirus (KSHV) inflammatory cytokine syndrome (KICS): A case study Open
Background: Kaposi sarcoma herpesvirus-inflammatory cytokine syndrome (KICS) is an exceedingly rare and complex condition characterised by the co-occurrence of Kaposi sarcoma and an aberrant inflammatory response mediated by cytokines with…
View article: The use of artificial intelligence in predicting maximal intercuspal position: A feasibility study
The use of artificial intelligence in predicting maximal intercuspal position: A feasibility study Open
The AI-predicted maxillomandibular relationship for maxillary and mandibular teeth scans shows discrepancies of less than 1.3 mm and 1.5° compared to the actual relationships.