Kacper Packi
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View article: Melatonin as the Missing Link Between Sleep Deprivation and Immune Dysregulation: A Narrative Review
Melatonin as the Missing Link Between Sleep Deprivation and Immune Dysregulation: A Narrative Review Open
Sleep deprivation impairs immune function, and melatonin has emerged as a key mediator in this process. This narrative review analyzes 50 studies published between 2000 and 2025 to determine the extent to which reduced melatonin synthesis …
View article: Metabolomics in Childhood Asthma – a Promising Tool to Meet Various Clinical Needs
Metabolomics in Childhood Asthma – a Promising Tool to Meet Various Clinical Needs Open
Purpose of Review The aim of our review is to summarize the available literature where metabolomics was used in studies on childhood asthma, and to find metabolites that are diagnostic biomarker candidates in childhood asthma. Moreover, th…
View article: Comparison of Multiplex Arrays: AllergyChip and Alex2. IgE Detection for Inhalant Allergens
Comparison of Multiplex Arrays: AllergyChip and Alex2. IgE Detection for Inhalant Allergens Open
Background: Accurate diagnosis of IgE-mediated allergic diseases is crucial for effective management. This study compared the diagnostic performance of two multiplex allergy assays, AllergyChip and ALEX2, by measuring IgE reactivity to 31 …
View article: Eosinophilic Pneumonia Triggered by Toxocara canis in a Patient with Primary Ciliary Dyskinesia: A Clinical Case Report
Eosinophilic Pneumonia Triggered by Toxocara canis in a Patient with Primary Ciliary Dyskinesia: A Clinical Case Report Open
Primary ciliary dyskinesia (PCD) is a rare genetic disorder that affects the structure and function of cilia, primarily impacting the respiratory system. Kartagener syndrome, a subset of PCD, is characterized by situs inversus, bronchiecta…
View article: The Influence of the Protozoan Giardia lamblia on the Modulation of the Immune System and Alterations in Host Glucose and Lipid Metabolism
The Influence of the Protozoan Giardia lamblia on the Modulation of the Immune System and Alterations in Host Glucose and Lipid Metabolism Open
Giardia lamblia, the cause of giardiasis, significantly impacts patients with metabolic disorders related to insulin resistance (IR). Both giardiasis and metabolic disorders share elements such as chronic inflammation and intestinal dysbio…
View article: Correction: Matysiak et al. Diagnosis of Hymenoptera Venom Allergy: State of the Art, Challenges, and Perspectives. Biomedicines 2022, 10, 2170
Correction: Matysiak et al. Diagnosis of Hymenoptera Venom Allergy: State of the Art, Challenges, and Perspectives. Biomedicines 2022, 10, 2170 Open
In the original article [...]
View article: Amino Acid Profiling Identifies Disease-Specific Signatures in IgE-Mediated and Non-IgE-Mediated Food Allergy in Pediatric Patients with Atopic Dermatitis
Amino Acid Profiling Identifies Disease-Specific Signatures in IgE-Mediated and Non-IgE-Mediated Food Allergy in Pediatric Patients with Atopic Dermatitis Open
An IgE-mediated food allergy (FA) in atopic dermatitis (AD) children should be easily differentiated from other immune-mediated adverse effects related to food. Specific IgEs for particular protein components has provided additional diagno…
View article: Application of modern analytical techniques in the analysis of complex matrices of natural origin on the example of honeybee venom
Application of modern analytical techniques in the analysis of complex matrices of natural origin on the example of honeybee venom Open
Honeybee venom (HBV) is a product of natural origin with an extremely complex composition. It exhibits several beneficial pharmacological properties, for example anti-inflammatory, antimicrobial, antidiabetic, anti-arthritic, and anti-tumo…
View article: Food Allergies and Parasites in Children
Food Allergies and Parasites in Children Open
The dynamically growing incidence of food allergies forces the scientific community to develop new methods for their diagnosis, differentiation, and effective treatment. Parasitoses appear much less frequently in the scientific literature,…
View article: Changes in Serum Protein–Peptide Patterns in Atopic Children Allergic to Plant Storage Proteins
Changes in Serum Protein–Peptide Patterns in Atopic Children Allergic to Plant Storage Proteins Open
Next to cow’s milk and eggs, plant foods, i.e., legumes, tree nuts and cereal grains, most often sensitise atopic children. Storage proteins constitutes the most relevant protein fraction of plant foods, causing primary sensitisation. They…
View article: Ascariasis as a model to study the helminth/allergy relationships
Ascariasis as a model to study the helminth/allergy relationships Open
AMA Packi K, Rudek A. Ascariasis as a model to study the helminth/allergy relationships. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):220-227. doi:10.5114/pja.2023.131712. APA Packi, K., & Rudek, A. (2023). Ascariasis as …
View article: Cytokine profile in childhood asthma
Cytokine profile in childhood asthma Open
Childhood asthma is a chronic airway disease, which pathogenesis is markedly heterogeneous–with multiple phenotypes defining visible characteristics and endotypes defining molecular mechanisms. Cytokines and chemokines released during infl…
View article: Diagnosis of Hymenoptera Venom Allergy: State of the Art, Challenges, and Perspectives
Diagnosis of Hymenoptera Venom Allergy: State of the Art, Challenges, and Perspectives Open
Hymenoptera venom allergy is the most common cause of anaphylaxis in adults and the second-most frequent in children. The proper diagnosis of this life-threatening allergy remains a challenge. This review focuses on the current knowledge r…
View article: Analysis of the Serum Profile of Cytokines Involved in the T-Helper Cell Type 17 Immune Response Pathway in Atopic Children with Food Allergy
Analysis of the Serum Profile of Cytokines Involved in the T-Helper Cell Type 17 Immune Response Pathway in Atopic Children with Food Allergy Open
The main risk factor for the development of food allergies (FAs) in children is atopic dermatitis (AD). AD is usually recognized as the Th1/Th2 paradigm of allergic disease. Recently, the Th1/Th2 paradigm in allergy and autoimmunity has be…
View article: New Biomarkers of Hymenoptera Venom Allergy in a Group of Inflammation Factors
New Biomarkers of Hymenoptera Venom Allergy in a Group of Inflammation Factors Open
Hymenoptera venom allergy significantly affects the quality of life. Due to the divergences in the results of the available test and clinical symptoms of patients, the current widely applied diagnostic methods are often insufficient to cla…
View article: Alterations in Serum-Free Amino Acid Profiles in Childhood Asthma
Alterations in Serum-Free Amino Acid Profiles in Childhood Asthma Open
Asthma often begins in childhood, although making an early diagnosis is difficult. Clinical manifestations, the exclusion of other causes of bronchial obstruction, and responsiveness to anti-inflammatory therapy are the main tool of diagno…