Kacper Żukowski
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View article: A comparison of genomically enhanced breeding values predicted by different single-step approaches
A comparison of genomically enhanced breeding values predicted by different single-step approaches Open
Many countries are currently adopting the single-step model for national genetic evaluations of dairy cattle. The two most widely applied statistical formulations of the single-step model are Genomic Best Linear Unbiased Prediction (ssG-BL…
View article: Identification of Genes Related to Fat Deposition as Candidates for ER Stress Based on Combined RNA-ATAC Sequencing Analysis
Identification of Genes Related to Fat Deposition as Candidates for ER Stress Based on Combined RNA-ATAC Sequencing Analysis Open
Endoplasmic reticulum (ER) stress is associated with obesity as this state challenges lipid and carbohydrate metabolisms, resulting in glucolipotoxicity and endoplasmic reticulum dysfunction. It can be induced by excessive ectopic fat accu…
View article: The Effect of BSCL2 Gene on Fat Deposition Traits in Pigs
The Effect of BSCL2 Gene on Fat Deposition Traits in Pigs Open
BSCL2 encodes seipin, a transmembrane endoplasmic reticulum protein associated with lipodystrophy and severe metabolic complications, including diabetes and hepatic steatosis. In pigs, BSCL2 expression increases during adipocyte differenti…
View article: The association of gene polymorphisms with milk production and mastitis resistance phenotypic traits in dairy cattle
The association of gene polymorphisms with milk production and mastitis resistance phenotypic traits in dairy cattle Open
The aim of this study was to evaluate the association between gene polymorphisms (SNPs) and mastitis indicators and their relationship with milk production profitability in dairy herd. A functional analysis was also performed of five genes…
View article: Improvements in Quality Control and Library Preparation for Targeted Sequencing Allowed Detection of Potentially Pathogenic Alterations in Circulating Cell-Free DNA Derived from Plasma of Brain Tumor Patients
Improvements in Quality Control and Library Preparation for Targeted Sequencing Allowed Detection of Potentially Pathogenic Alterations in Circulating Cell-Free DNA Derived from Plasma of Brain Tumor Patients Open
Malignant gliomas are the most frequent primary brain tumors in adults. They are genetically heterogenous and invariably recur due to incomplete surgery and therapy resistance. Circulating tumor DNA (ctDNA) is a component of circulating ce…
View article: Variations in Fibrinogen-like 1 (FGL1) Gene Locus as a Genetic Marker Related to Fat Deposition Based on Pig Model and Liver RNA-Seq Data
Variations in Fibrinogen-like 1 (FGL1) Gene Locus as a Genetic Marker Related to Fat Deposition Based on Pig Model and Liver RNA-Seq Data Open
The goal of this study was to evaluate the effects of mutations in the FGL1 gene associated with pig productive traits to enrich the genetic marker pool for further selection and to support the studies on FGL1 in the context of the fat dep…
View article: New long-non coding RNAs related to fat deposition based on pig model
New long-non coding RNAs related to fat deposition based on pig model Open
Obesity has been a problem in the last decades since the development of certain technologies has led to a faster pace of life, resulting in nutritional changes. Domestic pigs are an excellent animal model in recognition of adiposity-relate…
View article: Long-non Coding RNAs Related to Fat Deposition in Pigs Included lncRNA Corresponding to Human MALAT1
Long-non Coding RNAs Related to Fat Deposition in Pigs Included lncRNA Corresponding to Human MALAT1 Open
Obesity is a problem in the last decades since the development of different technologies forced the submission of a faster pace of life, resulting in nutrition style changes. In turn, domestic pigs are an excellent animal model in recognit…
View article: Benchmark of algorithms for multiple DNA sequence alignment across livestock species
Benchmark of algorithms for multiple DNA sequence alignment across livestock species Open
Background: Due to the growing amount of biological data, it is often necessary to select the most optimal estimation method for DNA sequence alignment across livestock species. One of the most important benches of genomics is to modelling…
View article: Association of bovine CXCL8 polymorphism with clinical mastitis and fertility trait in Polish HF cattle
Association of bovine CXCL8 polymorphism with clinical mastitis and fertility trait in Polish HF cattle Open
Background: The aim of this study was to investigate the relationship between CXCL8 (CXCL8c.105A>G and CXCL8c.210C>T) SNP polymorphism and the clinical mastitis and production trait in Polish HF cattle.Methods: The trait-associated CXCL8 S…
View article: Identification of CXCL8c.105A>G and CXCL8c.210C>T polymorphism in Polish HF cattle
Identification of CXCL8c.105A>G and CXCL8c.210C>T polymorphism in Polish HF cattle Open
Background: Bovine chemokine C-X-C motif legend 8 (CXCL8) also known as interleukin 8 (IL8) is a chemotactic factor that attracts neutrophils, basophils, and T-cells, in response to an inflammatory stimulus. The aim of this study was to in…
View article: Evaluation of analytical protocols of alignment mapping tools using high throughput next-generation genome sequencing data
Evaluation of analytical protocols of alignment mapping tools using high throughput next-generation genome sequencing data Open
Background: Ever since the development of first next-generation genome sequencer (NGS) in 2005, there are rapid developments of high throughput next-generation genome sequencing (HT-NGS) techniques and tools used in genetics and genomics h…
View article: NGS Screening for Identification of Novel Pexophagy-Related Mutation in Arabidopsis thaliana
NGS Screening for Identification of Novel Pexophagy-Related Mutation in Arabidopsis thaliana Open
Peroxisomes are the type of organelles in eukaryotic cells that are involved in different biochemical pathways depending on the type of cell. We have isolated a number of peroxisome unusual positioning (peup) mutants, which display the acc…
View article: Identification of Molecular Mechanisms Related to Pig Fatness at the Transcriptome and miRNAome Levels
Identification of Molecular Mechanisms Related to Pig Fatness at the Transcriptome and miRNAome Levels Open
Fat deposition and growth rate are closely related to pork quality and fattening efficiency. The next-generation sequencing (NGS) approach for transcriptome and miRNAome massive parallel sequencing of adipocyte tissue was applied to search…
View article: The SSC15 QTL-Rich Region Mutations Affecting Intramuscular Fat and Production Traits in Pigs
The SSC15 QTL-Rich Region Mutations Affecting Intramuscular Fat and Production Traits in Pigs Open
One of the more interesting regions in the pig genome is on chromosome 15 (115,800,000-122,100,000, SSC15, Sus scrofa 11.1) that has high quantitative trait locus (QTL) density associated with fattening, slaughter and meat quality characte…
View article: Genome-wide patterns of copy number variation in case-control mastitis study of Polish HF cows using high-density Illumina BovineSNP50 v3 BeadChip array
Genome-wide patterns of copy number variation in case-control mastitis study of Polish HF cows using high-density Illumina BovineSNP50 v3 BeadChip array Open
Background: The mastitis is one of the most important diseases affecting losses of milk yield and functional longevity resulting in economic losses in dairy farms. The cow's inflammation of the mammary gland is a consequence of complex pro…
View article: Evaluation of SCD, ACACA and FASN Mutations: Effects on Pork Quality and Other Production Traits in Pigs Selected Based on RNA-Seq Results
Evaluation of SCD, ACACA and FASN Mutations: Effects on Pork Quality and Other Production Traits in Pigs Selected Based on RNA-Seq Results Open
In recent years, pig producers have struggled with the problem of low intramuscular fat levels in pork, which impacts palatability and ultimately meat quality. Reduced levels of intramuscular fat are likely the result of breeding objective…
View article: Polymorphism of the Myostatin (MSTN) Gene in Landes and Kielecka Geese Breeds
Polymorphism of the Myostatin (MSTN) Gene in Landes and Kielecka Geese Breeds Open
Myostatin, also known as growth differentiation factor 8 (GDF8), belongs to the TGF- β superfamily of proteins. MSTN is a highly conserved protein that acts as a negative regulator of skeletal muscle growth. Loss of myostatin functionality…
View article: The Pituitary Transcriptional Response Related to Feed Conversion in Pigs
The Pituitary Transcriptional Response Related to Feed Conversion in Pigs Open
Over the decades, pig breeding objectives have focused on improving the meat content in the carcass without taking into consideration the more effective fattening indicators that affect feed conversion. At present, pig growth traits associ…
View article: Transcriptomic Changes in Broiler Chicken Hypothalamus during Growth and Development
Transcriptomic Changes in Broiler Chicken Hypothalamus during Growth and Development Open
The hypothalamus plays an overarching role that is reflected in the physiological processes observed in the entire organism. The hypothalamus regulates selected metabolic processes and activities of the autonomic nervous system. The avian …
View article: Examining the Genetic Background of Porcine Muscle Growth and Development Based on Transcriptome and miRNAome Data
Examining the Genetic Background of Porcine Muscle Growth and Development Based on Transcriptome and miRNAome Data Open
Recently, selection in pigs has been focused on improving the lean meat content in carcasses; this focus has been most evident in breeds constituting a paternal component in breeding. Such sire-breeds are used to improve the meat quantity …
View article: Examining the Genetic Background of Porcine Muscle Growth and Development Based on Transcriptome and miRNAome Data
Examining the Genetic Background of Porcine Muscle Growth and Development Based on Transcriptome and miRNAome Data Open
Recently, selection in pigs has been focused on improving the lean meat content in carcasses; this focus has been most evident in breeds constituting a paternal component in breeding. Such sire-breeds are used to improve the meat quantity …
View article: Screening for candidate genes related with histological microstructure, meat quality and carcass characteristic in pig based on RNA-seq data
Screening for candidate genes related with histological microstructure, meat quality and carcass characteristic in pig based on RNA-seq data Open
This study's results indicate that the SNP calling analysis based on RNA-seq data can be used to search candidate genes and establish the genetic basis of phenotypic traits. The presented results can be used for future studies evaluating t…
View article: A comprehensive transcriptome analysis of skeletal muscles in two Polish pig breeds differing in fat and meat quality traits
A comprehensive transcriptome analysis of skeletal muscles in two Polish pig breeds differing in fat and meat quality traits Open
Pork is the most popular meat in the world. Unfortunately, the selection pressure focused on high meat content led to a reduction in pork quality. The present study used RNA-seq technology to identify metabolic process genes related to por…
View article: A comprehensive transcriptome analysis of skeletal muscles in two Polish pig breeds differing in fat and meat quality traits
A comprehensive transcriptome analysis of skeletal muscles in two Polish pig breeds differing in fat and meat quality traits Open
Pork is the most popular meat in the world. Unfortunately, the selection pressure focused on high meat content led to a reduction in pork quality. The present study used RNA-seq technology to identify metabolic process genes related to por…