KaeChandra Weyenberg
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View article: Zebrafish models of human-duplicated<i>SRGAP2</i>reveal novel functions in microglia and visual system development
Zebrafish models of human-duplicated<i>SRGAP2</i>reveal novel functions in microglia and visual system development Open
The expansion of the human SRGAP2 family, resulting in a human-specific paralog SRGAP2C, likely contributed to altered evolutionary brain features. The introduction of SRGAP2C in mouse models is associated with changes in cortical neuronal…
View article: Evaluation of CRISPR gene-editing tools in zebrafish
Evaluation of CRISPR gene-editing tools in zebrafish Open
Background Zebrafish have practical features that make them a useful model for higher-throughput tests of gene function using CRISPR/Cas9 editing to create ‘knockout’ models. In particular, the use of G 0 mosaic mutants has potential to in…
View article: Additional file 1 of Evaluation of CRISPR gene-editing tools in zebrafish
Additional file 1 of Evaluation of CRISPR gene-editing tools in zebrafish Open
Additional file 1: Supplementary Figure 1. Editing efficiencies across 50 gRNAs with different GC content. Supplementary Figure 2. Mosaicism predicted using Illumina sequencing of G0 mutant larvae. Supplementary Figure 3. Network analyses …
View article: Evaluation of CRISPR gene-editing tools in zebrafish
Evaluation of CRISPR gene-editing tools in zebrafish Open
Background Zebrafish have practical features that make them a useful model for higher-throughput tests of gene function using CRISPR/Cas9 editing to create ‘knockout’ models. In particular, the use of G 0 mosaic mutants has potential to in…
View article: Assessment of autism zebrafish mutant models using a high-throughput larval phenotyping platform
Assessment of autism zebrafish mutant models using a high-throughput larval phenotyping platform Open
In recent years zebrafish have become commonly used as a model for studying human traits and disorders. Their small size, high fecundity, and rapid development allow for more high-throughput experiments compared to other vertebrate models.…