Kah Min Yap
YOU?
Author Swipe
View article: 297 Identifying optimal tumour-specific genes for CRISPR/Cas9 engineering of armoured CAR T cells with enhanced safety and efficacy
297 Identifying optimal tumour-specific genes for CRISPR/Cas9 engineering of armoured CAR T cells with enhanced safety and efficacy Open
View article: Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors
Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors Open
View article: Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery Open
The efficacy of chimeric antigen receptor (CAR) T cell therapy in solid tumours is limited by immunosuppression and antigen heterogeneity1-3. To overcome these barriers, 'armoured' CAR T cells, which secrete proinflammatory cyto…
View article: CRISPR engineering of armored CAR T cells enables tumor restricted payload delivery with enhanced efficacy and safety
CRISPR engineering of armored CAR T cells enables tumor restricted payload delivery with enhanced efficacy and safety Open
The efficacy of chimeric antig en receptor (CAR) T cell therapy in solid tumors is limited by immunosuppression and antigen heterogeneity. To overcome these barriers, “armored” CAR T cells, which secrete proinflammatory cytokines, have bee…
View article: FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy Open
View article: Tumor-site directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors
Tumor-site directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors Open
The efficacy of Chimeric Antigen Receptor (CAR) T cells against solid tumors is limited by immunosuppressive factors in the tumor microenvironment (TME) including adenosine, which suppresses CAR T cells through activation of the A2A recept…
View article: Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors
Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors Open
The efficacy of chimeric antigen receptor (CAR) T cell therapy is limited in solid tumors by several factors including the immunosuppressive tumor microenvironment that gives rise to poorly persisting and metabolically dysfunctional T cell…
View article: A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses
A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses Open
There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been developed for targeting the A 2A R receptor. Understanding of the mechanism by which A 2A R is reg…
View article: Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature
Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature Open
Despite recent advances in the diagnosis and treatment of breast cancer (BC), it remains a global health issue affecting millions of women annually. Poor prognosis in BC patients is often linked to drug resistance as well as the lack of ef…
View article: Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action
Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action Open
Globally, breast cancer is the most common cancer type and is one of the most significant causes of deaths in women. To date, multiple clinical interventions have been applied, including surgical resection, radiotherapy, endocrine therapy,…
View article: Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects
Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects Open