Ka‐Ho Wong
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View article: Medicare Part D Use and Costs for Immune-Mediated Neurologic Therapies
Medicare Part D Use and Costs for Immune-Mediated Neurologic Therapies Open
Importance The expansion in the number of disease-modifying therapies (DMTs) for immune-mediated neurologic diseases raises critical questions about trends in their use and cost over time and whether this growth could be contributing to es…
View article: An updated, comprehensive meta-analysis of the treatment of anti-NMDAR encephalitis: Analysis, equipoise, and the urgent need for evidence over anecdote
An updated, comprehensive meta-analysis of the treatment of anti-NMDAR encephalitis: Analysis, equipoise, and the urgent need for evidence over anecdote Open
Since 2019, more patients have been treated early with first- and second-line immunotherapies. Functional outcomes have shown modest improvements, whereas mortality and relapse rates have remained unchanged.
View article: A Phase-2B Double-Blind Randomized International Prospective Trial of Inebilizumab in NMDAR Encephalitis: The ExTINGUISH Trial
A Phase-2B Double-Blind Randomized International Prospective Trial of Inebilizumab in NMDAR Encephalitis: The ExTINGUISH Trial Open
The ExTINGUISH trial will determine the safety and efficacy of inebilizumab as a treatment of NMDAR encephalitis while evaluating the utility of clinical, cognitive, and quality-of-life outcome measures and supporting standardized collecti…
View article: An Updated, Comprehensive Meta-Analysis of the Treatment of Anti-Nmdar Encephalitis: Analysis, Equipoise, and the Urgent Need for Evidence Over Anecdote
An Updated, Comprehensive Meta-Analysis of the Treatment of Anti-Nmdar Encephalitis: Analysis, Equipoise, and the Urgent Need for Evidence Over Anecdote Open
View article: Socioeconomic and medical determinants of state‐level subjective cognitive decline in the United States
Socioeconomic and medical determinants of state‐level subjective cognitive decline in the United States Open
INTRODUCTION It is important to understand the socioeconomic and medical determinants of subjective cognitive decline (SCD) at a population level in the United States. METHODS The primary outcomes are state‐level rates of SCD and SCD‐relat…
View article: Correlations of Socioeconomic and Clinical Determinants with United States County‐Level Stroke Prevalence
Correlations of Socioeconomic and Clinical Determinants with United States County‐Level Stroke Prevalence Open
Socioeconomic status (SES) is a multi‐faceted theoretical construct associated with stroke risk and outcomes. Knowing which SES measures best correlate with population stroke metrics would improve its accounting in observational research a…
View article: Trends in American Indian/Alaskan native self-reported stroke prevalence and associated modifiable risk factors in the United States from 2011-2021
Trends in American Indian/Alaskan native self-reported stroke prevalence and associated modifiable risk factors in the United States from 2011-2021 Open
View article: Cardiac Involvement in Neurosarcoidosis
Cardiac Involvement in Neurosarcoidosis Open
In this cohort, 12% of patients with NS also had confirmed CS. In addition, these patients had a high burden of cardiovascular disease not directly attributed to sarcoidosis. Our data suggest that patients with NS require comprehensive car…
View article: Neurologic involvement in seronegative primary Sjögren’s syndrome with positive minor salivary gland biopsy: a single-center experience
Neurologic involvement in seronegative primary Sjögren’s syndrome with positive minor salivary gland biopsy: a single-center experience Open
Objective To assess the demographics, neurologic manifestations, comorbidities, and treatment of patients with seronegative primary Sjögren’s syndrome (pSS). Patients and methods We conducted a retrospective chart review on patients with s…
View article: Telestroke value through the eyes of emergency medicine providers: A counterfactual analysis
Telestroke value through the eyes of emergency medicine providers: A counterfactual analysis Open
TS consult frequently results in both patient management change and increased EM knowledge of stroke management with increased likelihood of repeat usage. Discomfort in determining eligibility for thrombectomy points to educational opportu…
View article: Neurologic Manifestations of Common Variable Immunodeficiency
Neurologic Manifestations of Common Variable Immunodeficiency Open
Among survey respondents, there is a marked burden of neurologic symptoms. Given the impact of neurologic symptoms on health-related quality-of-life measures, clinicians should screen patients with common variable immunodeficiency for the …
View article: Characterization of Retinal Nerve Fiber Layer Thickness in a Cohort with Glutamic Acid Decarboxylase 65 and Glycine Receptor Autoimmunity
Characterization of Retinal Nerve Fiber Layer Thickness in a Cohort with Glutamic Acid Decarboxylase 65 and Glycine Receptor Autoimmunity Open
Objective To describe the retinal nerve fiber layer (RNFL) with the demographic and clinical profile in patients with glutamic acid decarboxylase 65 (GAD65) and glycine receptor (GlyR) neurological autoimmunity. Background GAD65 and GlyR a…
View article: The ExTINGUISH Trial: A Phase-2B Randomized Placebo-Controlled Trial of Inebilizumab in Anti-NMDA Receptor Encephalitis
The ExTINGUISH Trial: A Phase-2B Randomized Placebo-Controlled Trial of Inebilizumab in Anti-NMDA Receptor Encephalitis Open
Objective To assess the safety and efficacy of inebilizumab in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Background The lack of approved therapies for NMDAR encephalitis has led to substantial variability in tr…
View article: MOGAD in the Mountain West: Epidemiology and Outcomes in Pediatric and Adult Patients at Two Large Academic Referral Centers
MOGAD in the Mountain West: Epidemiology and Outcomes in Pediatric and Adult Patients at Two Large Academic Referral Centers Open
Objective To describe the characteristics and outcomes in adult and pediatric patients diagnosed with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at the two major referral centers in the Mountain West of the Uni…
View article: Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A <i>Post Hoc</i> Analysis of MESA
Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A <i>Post Hoc</i> Analysis of MESA Open
Background Higher blood pressure variability (BPV) is associated with the development of major vascular diseases, independent of mean blood pressure. However, despite data indicating that serum inflammatory markers are linked to hypertensi…
View article: GABA-A Receptor Encephalitis After Autologous Hematopoietic Stem Cell Transplant forMultiple Myeloma
GABA-A Receptor Encephalitis After Autologous Hematopoietic Stem Cell Transplant forMultiple Myeloma Open
We highlight the importance of considering anti-GABAAR encephalitis in patients with seizures, multifocal nonenhancing brain lesions, and a history of aHSCT for MM. Awareness in recovered post-aHSCT patients with MM may be cruci…
View article: Temporal profiles of systolic blood pressure variability and neurologic outcomes after endovascular thrombectomy
Temporal profiles of systolic blood pressure variability and neurologic outcomes after endovascular thrombectomy Open
Introduction: Observational studies have found an increased risk of hemorrhagic transformation and worse functional outcomes in patients with higher systolic blood pressure variability (BPV). However, the time-varying behavior of BPV after…
View article: Blood Pressure Trajectory Groups and Outcome After Endovascular Thrombectomy: A Multicenter Study
Blood Pressure Trajectory Groups and Outcome After Endovascular Thrombectomy: A Multicenter Study Open
Background: Elevated blood pressure after endovascular thrombectomy (EVT) has been associated with an increased risk of hemorrhagic transformation and poor functional outcomes. However, the optimal hemodynamic management after EVT remains …
View article: Increased Blood Pressure Variability and the Risk of Probable Dementia or Mild Cognitive Impairment: A Post Hoc Analysis of the SPRINT MIND Trial
Increased Blood Pressure Variability and the Risk of Probable Dementia or Mild Cognitive Impairment: A Post Hoc Analysis of the SPRINT MIND Trial Open
Background Increased systolic blood pressure variability (BPV) is associated with stroke, cardiovascular disease, and dementia and mild cognitive impairment. However, prior studies assessing the relationship between BPV and dementia or mil…
View article: Modern Look at Transverse Myelitis and Inflammatory Myelopathy
Modern Look at Transverse Myelitis and Inflammatory Myelopathy Open
This national TM review highlights the relatively high prevalence of TM in a modern cohort. It also underscores the importance of a precise and thorough workup in this disabling disorder to ensure diagnostic precision and ensure optimal ma…
View article: Midlife Blood Pressure Variability and Risk of All-Cause Mortality and Cardiovascular Events During Extended Follow-up
Midlife Blood Pressure Variability and Risk of All-Cause Mortality and Cardiovascular Events During Extended Follow-up Open
BACKGROUND Studies demonstrate an association between visit-to-visit blood pressure variability (BPV) and cardiovascular events and death. We aimed to determine the long-term cardiovascular and mortality effects of BPV in midlife in partic…
View article: White Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial
White Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial Open
View article: Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis
Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis Open
Introduction: Current ischemic stroke risk prediction is primarily based on clinical factors, rather than imaging or laboratory markers. We examined the relationship between baseline ultrasound and inflammation measurements a…
View article: Effect of Premorbid Anxiolytic Medications on Ischemic Stroke Functional Outcome
Effect of Premorbid Anxiolytic Medications on Ischemic Stroke Functional Outcome Open
View article: Supplementary Material for: Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis
Supplementary Material for: Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis Open
Introduction: Current ischemic stroke risk prediction is primarily based on clinical factors, rather than imaging or laboratory markers. We examined the relationship between baseline ultrasound and inflammation measurements a…
View article: Prediction of death after endovascular thrombectomy in the extended window: a secondary analysis of DEFUSE 3 "
Prediction of death after endovascular thrombectomy in the extended window: a secondary analysis of DEFUSE 3 " Open
Background The Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 (DEFUSE 3) clinical trial assessed the use of endovascular thrombectomy (EVT) during the period 6–16 hours after last normal in selected patients. This …
View article: Diabetic Retinopathy and Risk of Stroke
Diabetic Retinopathy and Risk of Stroke Open
Background and Purpose: Diabetic retinopathy (DR) is a common microvascular complication of diabetes, which causes damage to the retina and may lead to rapid vision loss. Previous research has shown that the macrovascular complications of …
View article: Blood Pressure Variability and Cardiovascular Outcomes in Patients With Prior Stroke
Blood Pressure Variability and Cardiovascular Outcomes in Patients With Prior Stroke Open
Background and Purpose— Every year in the United States, almost 185 000 ischemic strokes occur in patients with a prior stroke. Recurrent stroke has significantly higher morbidity and mortality. Among modifiable risk factors for recurrent …
View article: Carotid Artery Stiffness Accurately Predicts White Matter Hyperintensity Volume 20 Years Later: A Secondary Analysis of the Atherosclerosis Risk in the Community Study
Carotid Artery Stiffness Accurately Predicts White Matter Hyperintensity Volume 20 Years Later: A Secondary Analysis of the Atherosclerosis Risk in the Community Study Open
Sonography measurements of carotid artery stiffness are predictive of white matter hyperintensity volume and total brain volume on MR imaging more than 20 years later. The association is more robust for white matter hyperintensity volume t…