Kai Bötzel
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View article: Head position control strategies in progressive Supranuclear Palsy versus Idiopathic Parkinson’s Disease during dynamic-on-static platform tilt
Head position control strategies in progressive Supranuclear Palsy versus Idiopathic Parkinson’s Disease during dynamic-on-static platform tilt Open
Objectives We investigated differences in head stabilization among Progressive Supranuclear Palsy (PSP), advanced Idiopathic Parkinson’s Disease (IPD) and healthy controls during passive anteroposterior platform tilting to determine factor…
View article: Speech and Nonspeech Parameters in the Clinical Assessment of Dysarthria: A Dimensional Analysis
Speech and Nonspeech Parameters in the Clinical Assessment of Dysarthria: A Dimensional Analysis Open
Nonspeech (or paraspeech) parameters are widely used in clinical assessment of speech impairment in persons with dysarthria (PWD). Virtually every standard clinical instrument used in dysarthria diagnostics includes nonspeech parameters, o…
View article: Impact of Partial Volume Correction on [18F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome
Impact of Partial Volume Correction on [18F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome Open
Corticobasal syndrome (CBS) is a rare neurodegenerative condition characterized by four-repeat tau aggregation in the cortical and subcortical brain regions and accompanied by severe atrophy. The aim of this study was to evaluate partial v…
View article: Resistance Training Combined with Balance or Gait Training for Patients with Parkinson’s Disease: A Randomized Controlled Pilot Study
Resistance Training Combined with Balance or Gait Training for Patients with Parkinson’s Disease: A Randomized Controlled Pilot Study Open
Background . Gait and balance disorders in patients with idiopathic Parkinson’s disease (PD) lead to major mobility limitations. To counteract this, physical therapy such as gait, balance, or resistance training is applied. Integrative tra…
View article: Binding characteristics of [<sup>18</sup>F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET
Binding characteristics of [<sup>18</sup>F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET Open
The novel tau-PET tracer [ 18 F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer’s disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [ 18 F]PI-2620 binding…
View article: Cortical [<scp><sup>18</sup>F</scp>]<scp>PI</scp>‐2620 Binding Differentiates Corticobasal Syndrome Subtypes
Cortical [<span><sup>18</sup>F</span>]<span>PI</span>‐2620 Binding Differentiates Corticobasal Syndrome Subtypes Open
Background Corticobasal syndrome is associated with cerebral protein aggregates composed of 4‐repeat (~50% of cases) or mixed 3‐repeat/4‐repeat tau isoforms (~25% of cases) or nontauopathies (~25% of cases). Objectives The aim of this sing…
View article: Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease
Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease Open
Parkinson's disease (PD) is known to involve the peripheral nervous system (PNS) and the enteric nervous system (ENS). Functional changes in PNS and ENS appear early in the course of the disease and are responsible for some of the non-moto…
View article: Physiological and pathological changes in the enteric nervous system of rotenone-exposed mice as early biomarkers for Parkinson’s disease
Physiological and pathological changes in the enteric nervous system of rotenone-exposed mice as early biomarkers for Parkinson’s disease Open
Parkinson’s disease (PD) is known to involve the peripheral nervous system (PNS) and the enteric nervous system (ENS). Functional changes in PNS and ENS appear early in the course of the disease and are responsible for some of the non-moto…
View article: In Vivo Assessment of Neuroinflammation in <scp>4‐Repeat</scp> Tauopathies
In Vivo Assessment of Neuroinflammation in <span>4‐Repeat</span> Tauopathies Open
Background Neuroinflammation has received growing interest as a therapeutic target in neurodegenerative disorders, including 4‐repeat tauopathies. Objectives The aim of this cross‐sectional study was to investigate 18 kDa translocator prot…
View article: Establishment of a Visual Analog Scale for DBS Programming (VISUAL-STIM Trial)
Establishment of a Visual Analog Scale for DBS Programming (VISUAL-STIM Trial) Open
Background: Deep brain stimulation (DBS) has become a standard treatment for advanced stages of Parkinson's disease, essential tremor, and dystonia. In addition to the correct surgical device implantation, effective programming is regarded…
View article: Issue Information
Issue Information Open
Canada & Mexico), €1375.00(Europe), £1090.00(UK), US$2131.00 (Rest of World).Prices are exclusive of tax.Asia-Pacific GST,
View article: FGF2 Affects Parkinson’s Disease-Associated Molecular Networks Through Exosomal Rab8b/Rab31
FGF2 Affects Parkinson’s Disease-Associated Molecular Networks Through Exosomal Rab8b/Rab31 Open
Ras-associated binding (Rab) proteins are small GTPases that regulate the trafficking of membrane components during endocytosis and exocytosis including the release of extracellular vesicles (EVs). Parkinson's disease (PD) is one of the mo…
View article: Loss‐of‐Function Variants in <scp>HOPS</scp> Complex Genes <scp><i>VPS16</i></scp> and <scp><i>VPS41</i></scp> Cause Early Onset Dystonia Associated with Lysosomal Abnormalities
Loss‐of‐Function Variants in <span>HOPS</span> Complex Genes <span><i>VPS16</i></span> and <span><i>VPS41</i></span> Cause Early Onset Dystonia Associated with Lysosomal Abnormalities Open
Objectives The majority of people with suspected genetic dystonia remain undiagnosed after maximal investigation, implying that a number of causative genes have not yet been recognized. We aimed to investigate this paucity of diagnoses. Me…
View article: In vivo Assessment of Neuroinflammation in 4-Repeat Tauopathies
In vivo Assessment of Neuroinflammation in 4-Repeat Tauopathies Open
Objective The aim of this cross-sectional single center study was to investigate 18kDa translocator protein (TSPO)-PET as a biomarker for microglial activation in the 4-repeat tauopathies corticobasal degeneration and progressive supranucl…
View article: Assessment of <sup>18</sup>F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy
Assessment of <sup>18</sup>F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy Open
This multicenter evaluation indicates a value of 18F-PI-2620 to differentiate suspected patients with PSP, potentially facilitating more reliable diagnosis of PSP.
View article: Fibroblast Growth Factor 2‐Mediated Regulation of Neuronal Exosome Release Depends on VAMP3/Cellubrevin in Hippocampal Neurons
Fibroblast Growth Factor 2‐Mediated Regulation of Neuronal Exosome Release Depends on VAMP3/Cellubrevin in Hippocampal Neurons Open
Extracellular vesicles (EVs) are endogenous membrane‐derived vesicles that shuttle bioactive molecules between glia and neurons, thereby promoting neuronal survival and plasticity in the central nervous system (CNS) and contributing to neu…
View article: PET Imaging of Astrogliosis and Tau Facilitates Diagnosis of Parkinsonian Syndromes
PET Imaging of Astrogliosis and Tau Facilitates Diagnosis of Parkinsonian Syndromes Open
Neurodegenerative parkinsonian syndromes comprise a number of disorders that are characterized by similar clinical features but are separated on the basis of different pathologies, i.e., aggregates of α-synuclein or tau protein. Due to the…
View article: Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial
Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial Open
BACKGROUND Multiple system atrophy is a rare neurodegenerative disease characterised by aggregation of \\textgreeka-synuclein in oligodendrocytes and neurons. The polyphenol epigallocatechin gallate inhibits \\textgreeka-synuclein aggregat…
View article: Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression
Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression Open
Parkinson’s disease (PD) represents an increasing problem in society. The oligomerization of alpha-synuclein (αSyn) is a suggested key event in its pathogenesis, yet the pathological modes of action remain to be fully elucidated. To identi…
View article: Deep Brain Stimulation Programming for Movement Disorders: Current Concepts and Evidence-Based Strategies
Deep Brain Stimulation Programming for Movement Disorders: Current Concepts and Evidence-Based Strategies Open
Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of Parkinson's disease, medically intractable essential tremor, and complicated segmental and generalized dystonia. In addition to accurate electrode place…
View article: Deep Brain Stimulation Programming 2.0: Future Perspectives for Target Identification and Adaptive Closed Loop Stimulation
Deep Brain Stimulation Programming 2.0: Future Perspectives for Target Identification and Adaptive Closed Loop Stimulation Open
Deep brain stimulation has developed into an established treatment for movement disorders and is being actively investigated for numerous other neurological as well as psychiatric disorders. An accurate electrode placement in the target ar…
View article: Clinical Routine FDG-PET Imaging of Suspected Progressive Supranuclear Palsy and Corticobasal Degeneration: A Gatekeeper for Subsequent Tau-PET Imaging?
Clinical Routine FDG-PET Imaging of Suspected Progressive Supranuclear Palsy and Corticobasal Degeneration: A Gatekeeper for Subsequent Tau-PET Imaging? Open
Background: F-18-fluordeoxyglucose positron emission tomography (FDG-PET) is widely used for discriminative diagnosis of tau-positive atypical parkinsonian syndromes (T+APS). This approach now stands to be augmented with more specific tau …
View article: Qualitative postural control differences in Idiopathic Parkinson’s Disease vs. Progressive Supranuclear Palsy with dynamic-on-static platform tilt
Qualitative postural control differences in Idiopathic Parkinson’s Disease vs. Progressive Supranuclear Palsy with dynamic-on-static platform tilt Open
The identification of disease-specific postural abnormalities shown here may be helpful for diagnostic as well as therapeutic discriminations of PSP vs. IPD.
View article: Postural Stabilization Differences in Idiopathic Parkinson’s Disease and Progressive Supranuclear Palsy during Self-Triggered Fast Forward Weight Lifting
Postural Stabilization Differences in Idiopathic Parkinson’s Disease and Progressive Supranuclear Palsy during Self-Triggered Fast Forward Weight Lifting Open
Progressive supranuclear palsy (PSP) and late-stage idiopathic Parkinson's disease (IPD) are neurodegenerative movement disorders resulting in different postural instability and falling symptoms. IPD falls occur usually forward in late sta…