Kai Huang
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View article: Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice Open
Obesity is a major global health challenge, and promoting the browning of white adipose tissue (WAT) represents a promising therapeutic strategy. However, pharmacological approaches to induce adipose thermogenesis remain limited. Through a…
View article: Time dynamics of symptom progression in patients with acute pancreatitis: a Dynamic Time Warping analysis
Time dynamics of symptom progression in patients with acute pancreatitis: a Dynamic Time Warping analysis Open
Background Acute pancreatitis (AP) morbidity has been increasing in recent years. Patients with AP exhibit highly variable symptom patterns over time, posting challenges to traditional analytical methods. Dynamic Time Warping (DTW) effecti…
View article: Clathrin mediated endocytosis targeting chimera for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy
Clathrin mediated endocytosis targeting chimera for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy Open
Rationale: T cell exhaustion, mediated by the expression of inhibitory receptor proteins, significantly reduces their anti-tumor efficacy. Therefore, strategies aimed at degrading membrane proteins have emerged as promising approaches for …
View article: Multi-Scale Electromechanical Impedance-Based Bolt Loosening Identification Using Attention-Enhanced Parallel CNN
Multi-Scale Electromechanical Impedance-Based Bolt Loosening Identification Using Attention-Enhanced Parallel CNN Open
Bolted connections are extensively utilized in aerospace, civil, and mechanical systems for structural assembly. However, inevitable structural vibrations can induce bolt loosening, leading to preload reduction and potential structural fai…
View article: Construction of a lncRNA–miRNA–mRNA Network for Biomarker Identification in Intervertebral Disc Degeneration
Construction of a lncRNA–miRNA–mRNA Network for Biomarker Identification in Intervertebral Disc Degeneration Open
This study identified key mRNAs implicated in IDD progression and provides new insights into the regulatory roles of ceRNA networks in the disease. These findings may contribute to the development of novel diagnostic biomarkers and therape…
View article: Modified stress hyperglycemia ratio identifies the risk of early cardiovascular complications in patients with acute myocardial infarction
Modified stress hyperglycemia ratio identifies the risk of early cardiovascular complications in patients with acute myocardial infarction Open
Background Stress hyperglycemia ratio (SHR) has been associated with poor outcomes in patients with acute myocardial infarction (AMI). Modified SHR (mSHR) is defined as the highest SHR observed within the first 24 h of admission. However, …
View article: Long noncoding RNA Nron and its functional motif modulate macrophage-mediated inflammatory response
Long noncoding RNA Nron and its functional motif modulate macrophage-mediated inflammatory response Open
Nron serves as a crucial negative regulator of excessive inflammatory responses, and its functional motifs can be used as a potential therapeutic agent for inflammatory diseases such as sepsis.
View article: Enhancing rate capability of amorphous silicon thin film anodes by n-type doping for lithium-ion batteries
Enhancing rate capability of amorphous silicon thin film anodes by n-type doping for lithium-ion batteries Open
This study investigates the fabrication of low-resistivity n-type (nSi) and p-type (pSi) amorphous silicon (a-Si) thin films by magnetron sputtering and comparatively evaluates their electrochemical performance as anodes for thin film lith…
View article: A SaBOX/Co catalyst designed for facile access to the challenging copolymers of vinyl ester and methacrylate
A SaBOX/Co catalyst designed for facile access to the challenging copolymers of vinyl ester and methacrylate Open
Copolymerization of more activated methacrylates and less activated vinyl esters is challenging because of their large difference in reactivity ratio. This severely limits the development of high-performance materials. Herein, we design a …
View article: Risk factors for osteomyelitis: a systematic review and meta-analysis
Risk factors for osteomyelitis: a systematic review and meta-analysis Open
Background: Osteomyelitis (OM) is a serious infection of the bone, often resulting from diabetic foot ulcers, trauma, or surgical interventions. Given its complex pathophysiology and recurrent nature, identifying reliable risk factors is e…
View article: Role of Macrophage PARP1 in the Regulation of Crosstalk between Adipose Immune Cells and Adipocytes during Diet-induced Obesity
Role of Macrophage PARP1 in the Regulation of Crosstalk between Adipose Immune Cells and Adipocytes during Diet-induced Obesity Open
Adipose tissue consists of heterogeneous cell populations, including macrophages, which play a key role in maintaining adipose tissue homeostasis. We previously identified PARP1 as a critical regulator of proadipogenic gene expression in p…
View article: Burden of hypertensive heart disease attributed to metabolic factors from 1990 to 2021 at global, regional, and national levels: an analysis of the global burden of disease study 2021
Burden of hypertensive heart disease attributed to metabolic factors from 1990 to 2021 at global, regional, and national levels: an analysis of the global burden of disease study 2021 Open
Background Metabolic factors have an increasing impact on hypertensive heart disease (HHD). This study analyzes the global burden trends of HHD from 1990–2021, focusing on the contributions of high systolic blood pressure (HSBP) and high b…
View article: Non‐Targeted Metabolomics Analysis of Metabolite Differences in <i>Inocutis tamaricis</i> Under Different Culture Conditions
Non‐Targeted Metabolomics Analysis of Metabolite Differences in <i>Inocutis tamaricis</i> Under Different Culture Conditions Open
Inocutis tamaricis is a medicinal fungus with significant pharmacological activity. In this study, ultra‐high performance liquid chromatography‐high resolution mass spectrometry (UPLC/MS) was used to conduct a comprehensive non‐targeted me…
View article: Comparative analysis of trends in the burden of motor neuron disease in China, the United States, and globally from 1990 to 2021: projections for 2022–2041
Comparative analysis of trends in the burden of motor neuron disease in China, the United States, and globally from 1990 to 2021: projections for 2022–2041 Open
Background Motor Neuron Disease (MND) is a neurodegenerative disorder with low incidence (4–8 per 100,000), but high disability and mortality. This study analyzes MND burden in China, the U.S., and Globally from 1990 to 2021, covering tren…
View article: <span style="background: white;">Planting Patterns Affect the Differences in Growth and Its Responses to Nitrogen Forms and Levels Between Three Invasive and Their Respective Related Native Species<span style="color: windowtext; mso-color-alt: windowtext; background: white;">
<span>Planting Patterns Affect the Differences in Growth and Its Responses to Nitrogen Forms and Levels Between Three Invasive and Their Respective Related Native Species<span> Open
Global change such as atmospheric nitrogen (N) deposition can facilitate alien plant invasions, which is often attributed to the increase in soil N availability. However, few studies have considered the effects of global change-driven alte…
View article: Modular Engineering of <i>Escherichia coli</i> for Enhanced Nickel Uptake, Survival, Biomineralization, and Hydrogen-Supported Bioremediation
Modular Engineering of <i>Escherichia coli</i> for Enhanced Nickel Uptake, Survival, Biomineralization, and Hydrogen-Supported Bioremediation Open
Nickel contamination poses increasing environmental and industrial challenges, demanding effective and sustainable remediation strategies. Here, we present a modular synthetic biology approach to engineer Escherichia coli for efficient nic…
View article: <b>BAP1 </b><b>suppresses</b><b> white adipose tissue browning and thermogenesis</b><b>through deubiquitinating KDM1B</b>
<b>BAP1 </b><b>suppresses</b><b> white adipose tissue browning and thermogenesis</b><b>through deubiquitinating KDM1B</b> Open
Obesity is a growing global health threat, and inducing browning of white adipose tissue (WAT) to increase energy expenditure has become an attractive strategy for treating obesity and related metabolic complications. BRCA1-associated prot…
View article: <b>BAP1 </b><b>suppresses</b><b> white adipose tissue browning and thermogenesis</b><b>through deubiquitinating KDM1B</b>
<b>BAP1 </b><b>suppresses</b><b> white adipose tissue browning and thermogenesis</b><b>through deubiquitinating KDM1B</b> Open
Obesity is a growing global health threat, and inducing browning of white adipose tissue (WAT) to increase energy expenditure has become an attractive strategy for treating obesity and related metabolic complications. BRCA1-associated prot…
View article: Can the Return of Rural Labor Effectively Stimulate the Demand for Land? Empirical Evidence from Sichuan Province, China
Can the Return of Rural Labor Effectively Stimulate the Demand for Land? Empirical Evidence from Sichuan Province, China Open
Promoting moderate-scale land management is a crucial pathway for achieving the transformation of agricultural modernization in China. Whether migrant workers with the advantage of human capital can effectively promote moderate scale manag…
View article: Overcoming extensive abdominal adhesions: Utilizing mini-wound techniques for successful laparoscopic staging in cancer surgery
Overcoming extensive abdominal adhesions: Utilizing mini-wound techniques for successful laparoscopic staging in cancer surgery Open
An ultra-mini wound assisted laparoscopic surgery can be successfully applied in women with an extensive and widespread abdominal adhesion without increasing adverse events or prolonging length of hospital stay.