Fang Han
YOU?
Author Swipe
View article: Clinical Benefits of Combination Immunotherapy Over Standard Immunotherapy Monotherapy in Previously Treated Advanced Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis
Clinical Benefits of Combination Immunotherapy Over Standard Immunotherapy Monotherapy in Previously Treated Advanced Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis Open
Purpose Programmed cell death protein 1 (PD‐1) inhibitor monotherapy is the standard second‐line treatment for esophageal squamous cell carcinoma (ESCC), but the clinical response and survival outcomes still remain unsatisfactory. This sys…
View article: Trend Analysis of Fungal Infections Based on Culture among Inpatients in Henan Province from 2018 to 2023
Trend Analysis of Fungal Infections Based on Culture among Inpatients in Henan Province from 2018 to 2023 Open
With the increasing number of immunocompromised hosts, the epidemiological characteristics of fungal infections have undergone enormous changes worldwide, including in China. The epidemiology of fungal infections is diverse and varies worl…
View article: LncRNA PELATON regulates Th2 cell differentiation by miR-10b-5p/GATA3 axis in allergic rhinitis
LncRNA PELATON regulates Th2 cell differentiation by miR-10b-5p/GATA3 axis in allergic rhinitis Open
View article: A Correlation Study between Oral Microbiota and Traditional Chinese Medicine Syndromes among Patients with Pancreatic Cancer
A Correlation Study between Oral Microbiota and Traditional Chinese Medicine Syndromes among Patients with Pancreatic Cancer Open
Objective: The objective of this study was to investigate the differences in oral microbiota among patients with pancreatic cancer (PC) with different traditional Chinese medicine (TCM) syndromes and to explore the potential connection wit…
View article: Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice
Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice Open
L-lactate participates in metabolism, including the Cori cycle, but less is known about D-lactate. We found that circulating D-lactate was higher in humans and mice with obesity. D-lactate increased hepatic glycogen, triglycerides, and blo…
View article: Identification and validation a novel kinase-related gene signature for predicting prognosis and responsiveness to immunotherapy in hepatocellular carcinoma
Identification and validation a novel kinase-related gene signature for predicting prognosis and responsiveness to immunotherapy in hepatocellular carcinoma Open
Liver cancer research highlights the kinome's critical role in disease initiation and progression. However, comprehensive data analysis on the kinome's impact on hepatocellular carcinoma (HCC) prognosis is limited. We used the TCGA-LIHC mR…
View article: USP28 promotes PARP inhibitor resistance by enhancing SOX9-mediated DNA damage repair in ovarian cancer
USP28 promotes PARP inhibitor resistance by enhancing SOX9-mediated DNA damage repair in ovarian cancer Open
PARP inhibitor (PARPi) resistance presents a significant challenge in ovarian cancer treatment, necessitating the development of effective therapeutic strategies to overcome this resistance and improve patient outcomes. Our study demonstra…
View article: Characterization and Immune Functions of LcβLectin from Large Yellow Croaker (Larimichthys crocea): A Potential Antiviral Defense Molecule
Characterization and Immune Functions of LcβLectin from Large Yellow Croaker (Larimichthys crocea): A Potential Antiviral Defense Molecule Open
Large yellow croaker iridovirus (LYCIV) poses a significant threat to the large yellow croaker (Larimichthys crocea) aquaculture industry due to its rapid transmission and high lethality. Galectins, as evolutionarily conserved carbohydrate…
View article: Global burden and future trends of metabolic dysfunction-associated Steatotic liver disease: 1990-2021 to 2045
Global burden and future trends of metabolic dysfunction-associated Steatotic liver disease: 1990-2021 to 2045 Open
MASLD poses a significant burden with notable gender and regional disparities. The projected increase by 2045 underscores the need for urgent public health interventions and targeted strategies to mitigate this growing epidemic.
View article: Inhibition of LRRK2 Ameliorates <i>Aspergillus fumigatus</i> Keratitis by Regulating STING Signaling Pathways
Inhibition of LRRK2 Ameliorates <i>Aspergillus fumigatus</i> Keratitis by Regulating STING Signaling Pathways Open
LRRK2 inhibition ameliorates A. fumigatus-induced inflammation through modulating STING signaling pathways in both HCECs and mouse models. Our results suggest that targeted inhibition of LRRK2 could be a promising strategy for FK treatment.
View article: Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies
Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies Open
View article: Exploring heparin’s protective mechanism against AGEs induced endothelial injury
Exploring heparin’s protective mechanism against AGEs induced endothelial injury Open
View article: Construction of tissue engineered cornea with skin-derived corneal endothelial-like cell and mechanism research for the cell differentiation
Construction of tissue engineered cornea with skin-derived corneal endothelial-like cell and mechanism research for the cell differentiation Open
Introduction Corneal endothelial transplantation accounts for most of corneal transplantation for treating corneal diseases, however severe shortage of corneal donors is the biggest obstacle. In our previous study, we differentiated human …
View article: The complex link between the gut microbiome and obesity-associated metabolic disorders: Mechanisms and therapeutic opportunities
The complex link between the gut microbiome and obesity-associated metabolic disorders: Mechanisms and therapeutic opportunities Open
Microbial interactions are widespread and important processes that support the link between disease and microbial ecology. The gut microbiota is a major source of microbial stimuli that can have detrimental or beneficial effects on human h…
View article: Sestrin2 knockout exacerbates high-fat diet induced metabolic disorders and complications in female mice
Sestrin2 knockout exacerbates high-fat diet induced metabolic disorders and complications in female mice Open
View article: Clinical Efficacy of Taxol Plus Platinum (TP) Chemotherapy Combined with Delayed Administration of PD-1 Inhibitors in Patients with Locally Advanced, Recurrent or Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Study
Clinical Efficacy of Taxol Plus Platinum (TP) Chemotherapy Combined with Delayed Administration of PD-1 Inhibitors in Patients with Locally Advanced, Recurrent or Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Study Open
The optimized sequence of PD-1 inhibitors administered 3-5 days after TP chemotherapy as the first-line treatment of ESCC demonstrated favorable treatment efficacy. Pretreatment NLR of less than 3 at the 3rd and 4th cycle of immunochemothe…
View article: Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet Open
View article: Exploring the multi-targeting phytoestrogen potential of Calycosin for cancer treatment: A review
Exploring the multi-targeting phytoestrogen potential of Calycosin for cancer treatment: A review Open
Cancer remains a significant challenge in the field of oncology, with the search for novel and effective treatments ongoing. Calycosin (CA), a phytoestrogen derived from traditional Chinese medicine, has garnered attention as a promising c…
View article: The impact of the senescent microenvironment on tumorigenesis: Insights for cancer therapy
The impact of the senescent microenvironment on tumorigenesis: Insights for cancer therapy Open
The growing global burden of cancer, especially among people aged 60 years and over, has become a key public health issue. This trend suggests the need for a deeper understanding of the various cancer types in order to develop universally …
View article: Functional significance of DNA methylation: epigenetic insights into Sjögren’s syndrome
Functional significance of DNA methylation: epigenetic insights into Sjögren’s syndrome Open
Sjögren’s syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease with a significant global prevalence. It is a complex condition that requires careful management and monitoring. Recent research indicates that epigenet…
View article: Elucidating the cardioprotective mechanisms of sodium-glucose cotransporter-2 inhibitors beyond glycemic control
Elucidating the cardioprotective mechanisms of sodium-glucose cotransporter-2 inhibitors beyond glycemic control Open
Sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as a pivotal intervention in diabetes management, offering significant cardiovascular benefits. Empagliflozin, in particular, has demonstrated cardioprotective effects beyond i…
View article: Magnetic resonance imaging with upconversion nanoprobes capable of crossing the blood-cerebrospinal fluid barrier
Magnetic resonance imaging with upconversion nanoprobes capable of crossing the blood-cerebrospinal fluid barrier Open
The central nervous system (CNS) maintains homeostasis with its surrounding environment by restricting the ingress of large hydrophilic molecules, immune cells, pathogens, and other external harmful substances to the brain. This function r…
View article: Deciphering the Effective Substances of Mangrove Plant Acanthus Ilicifolius Linn. Against Liver Injury
Deciphering the Effective Substances of Mangrove Plant Acanthus Ilicifolius Linn. Against Liver Injury Open
View article: Meta-analysis of the relationship between montelukast use and neuropsychiatric events in patients with allergic airway disease
Meta-analysis of the relationship between montelukast use and neuropsychiatric events in patients with allergic airway disease Open
View article: Changing trends of the diseases burden attributable to high BMI in Asia from 1990 to 2019: results from the global burden of disease study 2019
Changing trends of the diseases burden attributable to high BMI in Asia from 1990 to 2019: results from the global burden of disease study 2019 Open
Objective To analyse the trends of diseases burden attributed to high body mass index (BMI), including overweight and obesity, in Asia from 1990 to 2019. Design Observational study. Setting The data of 45 countries and regions in Asia were…
View article: CDCA7: A Comprehensive Pan-Cancer Analysis Reveals its Prognostic Significance, Immune Correlations, and Therapeutic Potential
CDCA7: A Comprehensive Pan-Cancer Analysis Reveals its Prognostic Significance, Immune Correlations, and Therapeutic Potential Open
Background Recent years have witnessed the emergence of Cell Division Cycle Associated 7 (CDCA7) as a participant in the genesis of diverse tumors. Despite this, comprehensive pan-cancer evaluations of CDCA7 remain scarce. Consequently, th…
View article: Diagnostic performance of prediction models for extraprostatic extension in prostate cancer: a systematic review and meta-analysis
Diagnostic performance of prediction models for extraprostatic extension in prostate cancer: a systematic review and meta-analysis Open
View article: Astrocytes in Post-Stroke Depression: Roles in Inflammation, Neurotransmission, and Neurotrophin Signaling
Astrocytes in Post-Stroke Depression: Roles in Inflammation, Neurotransmission, and Neurotrophin Signaling Open
View article: Global, Regional, and National Epidemiology of Diabetes in Children From 1990 to 2019
Global, Regional, and National Epidemiology of Diabetes in Children From 1990 to 2019 Open
Importance Diabetes in children is a global epidemic that causes various medical conditions associated with an increased incidence of premature death. Objective To investigate the trends in diabetes incidence, mortality, and disability-adj…
View article: Global, Regional, and National Burden of Pancreatic Cancer, 1990&ndash;2019: Results from the Global Burden of Disease Study 2019
Global, Regional, and National Burden of Pancreatic Cancer, 1990–2019: Results from the Global Burden of Disease Study 2019 Open
Aims: Pancreatic cancer (PC) is a malignant tumor with a strong invasive nature and low survival rate. We aimed to estimate the PC burden at the global, regional, and national levels in 204 countries from 1990 to 2019. Methods: Detailed da…