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View article: Activation of cGAS-STING signaling in senescent cells promotes the aging process by remodeling the functions of the immune system
Activation of cGAS-STING signaling in senescent cells promotes the aging process by remodeling the functions of the immune system Open
View article: An Investigation of Alexithymia Personality Features Versus Outcome: A Prospective 25-year Follow-up Study in Women With Breast Cancer Symptoms
An Investigation of Alexithymia Personality Features Versus Outcome: A Prospective 25-year Follow-up Study in Women With Breast Cancer Symptoms Open
Higher AT, as measured by the SAI, is associated with poorer long-term survival and correlates with psychological distress in women with BC symptoms. Incorporating SAI assessment may aid in identifying patients at risk of adverse psycholog…
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In this Issue Open
View article: Consensus on age‐related macular degeneration course curricula for general ophthalmologists and non‐ophthalmologist clinical staff: A Delphi study
Consensus on age‐related macular degeneration course curricula for general ophthalmologists and non‐ophthalmologist clinical staff: A Delphi study Open
Purpose To define the curriculum content for two interactive learning courses on age‐related macular degeneration (AMD): (1) an advanced course tailored for general ophthalmologists and (2) a basic course for non‐ophthalmologist healthcare…
View article: Psychological Stress <i>Versus</i> Outcome in Patients With Breast Disease and Breast Cancer: A Prospective 25-year Follow-up Study in Patients With Breast Cancer Symptoms
Psychological Stress <i>Versus</i> Outcome in Patients With Breast Disease and Breast Cancer: A Prospective 25-year Follow-up Study in Patients With Breast Cancer Symptoms Open
The FI scale, though underutilized, effectively captures PS and significantly predicts long-term outcomes in patients with breast disease. These findings suggest that incorporating the FI into diagnostic evaluations could enhance risk stra…
View article: The state of your journal: Acta Ophthalmologica in 2024
The state of your journal: Acta Ophthalmologica in 2024 Open
View article: Secretory autophagy and epithelial‐to‐mesenchymal transition in cadaveric <scp>AMD</scp> samples: Novel pathways in disease progression
Secretory autophagy and epithelial‐to‐mesenchymal transition in cadaveric <span>AMD</span> samples: Novel pathways in disease progression Open
Purpose To examine the presence of secretory autophagy and epithelial–mesenchymal transition (EMT) in the macular retinal pigment epithelium (RPE) of human cadaver eyes with different forms of age‐related macular degeneration (AMD). Method…
View article: Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease
Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease Open
View article: The role of secretory autophagy and exosomes in the accumulation of drusen during the development of age-related macular degeneration (AMD)
The role of secretory autophagy and exosomes in the accumulation of drusen during the development of age-related macular degeneration (AMD) Open
Age-related macular degeneration (AMD) is the most common disease of the elderly that leads to the loss of sight. So far, no satisfactory therapy exists for this complex eye disease. The appearance of extracellular deposits, called drusen,…
View article: Four Different Artificial Intelligence Models<i>Versus</i>Logistic Regression to Enhance the Diagnostic Accuracy of Fecal Immunochemical Test in the Detection of Colorectal Carcinoma in a Screening Setting
Four Different Artificial Intelligence Models<i>Versus</i>Logistic Regression to Enhance the Diagnostic Accuracy of Fecal Immunochemical Test in the Detection of Colorectal Carcinoma in a Screening Setting Open
AI models outperformed conventional LR and non-AI diagnostic features in improving FIT-based CRC screening. This is the first study to show that combining clinical data with FIT results in AI frameworks can significantly improve diagnostic…
View article: Serum RNA Profile Reflects Fluid Status and Atrophic Retinal Changes in Neovascular Age-Related Macular Degeneration
Serum RNA Profile Reflects Fluid Status and Atrophic Retinal Changes in Neovascular Age-Related Macular Degeneration Open
The increasing prevalence of age-related macular degeneration (AMD), a disease that can result in the loss of central vision, is an emerging problem worldwide due to aging societies. Growing patient numbers create a challenge for the healt…
View article: Rare genetic variation in PTPRB is associated with central serous chorioretinopathy, varicose veins and glaucoma
Rare genetic variation in PTPRB is associated with central serous chorioretinopathy, varicose veins and glaucoma Open
View article: Potential of autophagy in subretinal fibrosis in neovascular age-related macular degeneration
Potential of autophagy in subretinal fibrosis in neovascular age-related macular degeneration Open
View article: The Impact of State-trait Anxiety Inventory (STAI) Self-evaluation<i>versus</i>25-year Outcome: A Prospective Follow-up Study in Patients With Breast Cancer Symptoms
The Impact of State-trait Anxiety Inventory (STAI) Self-evaluation<i>versus</i>25-year Outcome: A Prospective Follow-up Study in Patients With Breast Cancer Symptoms Open
Although widely used to assess anxiety, STAI's long-term prognostic relevance in patients with BC symptoms has been largely overlooked. This 25-year prospective study is the first to demonstrate that lower STAI scores significantly predict…
View article: Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism
Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism Open
Background Tear fluid (TF) is a protein-rich solution that reflects pathophysiological changes in Alzheimer's disease (AD). Objective In this study, we examined whether TF proteins were differently expressed in persons with mild AD dementi…
View article: "Unravelling the pathogenesis of Cardiovascular Disease in Diabetes: Molecular Mechanisms and Clinical Implications”
"Unravelling the pathogenesis of Cardiovascular Disease in Diabetes: Molecular Mechanisms and Clinical Implications” Open
The pathophysiology of the link between diabetes and cardiovascular disease (CVD) is complex and multifactorial.various mechanisms contribute to the impairment in systolic and diastolicfunction in patients with diabetes, and there is an in…
View article: Free Interleukin 18 (IL-18F) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer
Free Interleukin 18 (IL-18F) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer Open
This is the first report to demonstrate a link between increased IL-18F levels and pain scales in MLa. IL-18F levels decreased significantly after operation and correlated with IL-18, IL-18BP, and 4-HNE blood levels, and inversely correlat…
View article: Artificial Intelligence Models Could Enhance the Diagnostic Accuracy (DA) of Fecal Immunochemical Test (FIT) in the Detection of Colorectal Adenoma in a Screening Setting
Artificial Intelligence Models Could Enhance the Diagnostic Accuracy (DA) of Fecal Immunochemical Test (FIT) in the Detection of Colorectal Adenoma in a Screening Setting Open
In detection of CRA, the AI models proved to be superior to the diagnostic features without AI. This is the first study to report that DA in the diagnosis of CRA can be enhanced by AI models that include clinical data of the patients and r…
View article: Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort
Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort Open
Differentially expressed systemic mRNAs that are linked to mitochondrial function, oxidative stress, and inflammation may have a role in the pathology of wAMD. Our observations provide new data for the understanding of the progression of w…
View article: Association of hearing, vision, and dual sensory impairment and risk of Alzheimer’s disease: a nested case-control study
Association of hearing, vision, and dual sensory impairment and risk of Alzheimer’s disease: a nested case-control study Open
View article: VEGF and ELAVL1/HuR protein levels are increased in dry and wet AMD patients. A new tile in the pathophysiologic mechanisms underlying RPE degeneration?
VEGF and ELAVL1/HuR protein levels are increased in dry and wet AMD patients. A new tile in the pathophysiologic mechanisms underlying RPE degeneration? Open
Age-related macular degeneration (AMD) is a common retinal pathology characterized by degeneration of macula's retinal pigment epithelium (RPE) and photoreceptors, visual impairment, or loss. Compared to wet AMD, dry AMD is more common, bu…
View article: Metformin Alleviates Inflammation and Induces Mitophagy in Human Retinal Pigment Epithelium Cells Suffering from Mitochondrial Damage
Metformin Alleviates Inflammation and Induces Mitophagy in Human Retinal Pigment Epithelium Cells Suffering from Mitochondrial Damage Open
Mitochondrial malfunction, excessive production of reactive oxygen species (ROS), deficient autophagy/mitophagy, and chronic inflammation are hallmarks of age-related macular degeneration (AMD). Metformin has been shown to activate mitopha…
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In this Issue Open
View article: Autophagy in drusen biogenesis secondary to age‐related macular degeneration
Autophagy in drusen biogenesis secondary to age‐related macular degeneration Open
Age‐related macular degeneration (AMD) is an emerging cause of blindness in aged people worldwide. One of the key signs of AMD is the degeneration of the retinal pigment epithelium (RPE), which is indispensable for the maintenance of the a…
View article: The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD Open
Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a crucial role in RPE health via phagocytosis and autophagy, which…
View article: Ventriculoperitoneal shunt patients and glaucoma: a cohort analysis of the NPH registry
Ventriculoperitoneal shunt patients and glaucoma: a cohort analysis of the NPH registry Open
Background Idiopathic Normal Pressure Hydrocephalus (iNPH) is a chronic condition affecting the elderly. It is characterized by a triad of symptoms and radiological findings. Glaucoma is the leading cause of irreversible blindness worldwid…
View article: Oxidative Stress, Persistent Inflammation and Blood Coagulation Alterations in Serum Proteome of Patients with Neovascular Age-Related Macular Degeneration
Oxidative Stress, Persistent Inflammation and Blood Coagulation Alterations in Serum Proteome of Patients with Neovascular Age-Related Macular Degeneration Open
Neovascular age-related macular degeneration (AMD) is a major cause of irreversible blindness in elderly populations in developed countries. AMD’s etiopathology is multifactorial, with strong environmental and genetic components, but the e…
View article: Rare genetic variation in VE-PTP is associated with central serous chorioretinopathy, venous dysfunction and glaucoma
Rare genetic variation in VE-PTP is associated with central serous chorioretinopathy, venous dysfunction and glaucoma Open
Central serous chorioretinopathy (CSC) is a fluid maculopathy whose etiology is not well understood. Abnormal choroidal veins in CSC patients have been shown to have similarities with varicose veins. To identify potential mechanisms, we an…
View article: Long-term Cumulative Incidence of Clinically Diagnosed Retinopathy in the Finnish Diabetes Prevention Study
Long-term Cumulative Incidence of Clinically Diagnosed Retinopathy in the Finnish Diabetes Prevention Study Open
Context Lifestyle intervention reduces the incidence of type 2 diabetes (T2D) in people with impaired glucose tolerance (IGT). Objective This work aimed to find out whether participation in an earlier lifestyle intervention had an effect o…
View article: Analysis of prognostic and predictive factors in neovascular age‐related macular degeneration Kuopio cohort
Analysis of prognostic and predictive factors in neovascular age‐related macular degeneration Kuopio cohort Open
Purpose The aim of the study was to explore factors affecting the progression of neovascular age‐related macular degeneration (nAMD) and identify predictive factors that can estimate the duration of intravitreal treatments. Methods This re…