Kai Klein
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View article: A Modular Solid Phase Synthesis Approach for Glycocalix[4]Arene Derivatives and Their Multivalent Presentation on Ultrasmall Gold Nanoparticles.
A Modular Solid Phase Synthesis Approach for Glycocalix[4]Arene Derivatives and Their Multivalent Presentation on Ultrasmall Gold Nanoparticles. Open
Gold nanoparticles and calix[n]arenes are well‐established platforms for creating multivalent carbohydrate ligands that enhance binding avidity and selectivity toward carbohydrate‐recognizing receptors, such as bacterial lectins. In this s…
View article: Bacteria (<i>E. coli</i>) take up ultrasmall gold nanoparticles (2 nm) as shown by different optical microscopic techniques (CLSM, SIM, STORM)
Bacteria (<i>E. coli</i>) take up ultrasmall gold nanoparticles (2 nm) as shown by different optical microscopic techniques (CLSM, SIM, STORM) Open
The uptake of fluorescently labeled ultrasmall gold nanoparticles (2 nm) by Gram‐negative Escherichia coli bacteria occurs within 1–3 hours. This was demonstrated by confocal laser scanning microscopy (CLSM), structured illumination micros…
View article: Covalent Attachment of Aggregation-Induced Emission Molecules to the Surface of Ultrasmall Gold Nanoparticles to Enhance Cell Penetration
Covalent Attachment of Aggregation-Induced Emission Molecules to the Surface of Ultrasmall Gold Nanoparticles to Enhance Cell Penetration Open
Three different alkyne-terminated aggregation-induced emission molecules based on a para-substituted di-thioether were attached to the surface of ultrasmall gold nanoparticles (2 nm) by copper-catalyzed azide–alkyne cycloaddition (click ch…
View article: Silencing of proinflammatory NF-κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA
Silencing of proinflammatory NF-κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA Open
Different kinds of alkyne-terminated siRNA duplexes were conjugated to azide-terminated ultrasmall gold nanoparticles (2 nm) via copper-catalyzed azide–alkyne cycloaddition, depending on the gene to be silenced.
View article: Front Cover: An Efficient Method for Covalent Surface Functionalization of Ultrasmall Metallic Nanoparticles by Surface Azidation Followed by Copper‐Catalyzed Azide‐Alkyne Cycloaddition (Click Chemistry) (ChemNanoMat 12/2021)
Front Cover: An Efficient Method for Covalent Surface Functionalization of Ultrasmall Metallic Nanoparticles by Surface Azidation Followed by Copper‐Catalyzed Azide‐Alkyne Cycloaddition (Click Chemistry) (ChemNanoMat 12/2021) Open
Ultrasmall gold nanoparticles can be conveniently surface-functionalized by azidation of surface-bound glutathione. A subsequent click reaction leads to covalently attached molecules in high yield with up to 50 mg per synthesis. The nature…
View article: An Efficient Method for Covalent Surface Functionalization of Ultrasmall Metallic Nanoparticles by Surface Azidation Followed by Copper‐Catalyzed Azide‐Alkyne Cycloaddition (Click Chemistry)
An Efficient Method for Covalent Surface Functionalization of Ultrasmall Metallic Nanoparticles by Surface Azidation Followed by Copper‐Catalyzed Azide‐Alkyne Cycloaddition (Click Chemistry) Open
The azidation of glutathione (GSH)‐functionalized ultrasmall gold nanoparticles (2 nm) by the azide transfer reagent imidazole‐1‐sulfonyl azide hydrogen sulfate leads to azide‐terminated nanoparticles with high yield. A subsequent copper‐c…
View article: pH‐Controlled Hierarchical Assembly/Disassembly of Multicompartment Micelles in Water
pH‐Controlled Hierarchical Assembly/Disassembly of Multicompartment Micelles in Water Open
Multicompartment micelles (MCMs) have become attractive drug delivery systems as they allow the separate storage of two or more incompatible cargos in their core compartments (e.g., drugs and dyes for imaging). A recent hierarchical self‐a…