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View article: Ultrasound-guided fine-needle cytology for cervical lymph nodes: a tertiary centre’s experience with the Sydney system
Ultrasound-guided fine-needle cytology for cervical lymph nodes: a tertiary centre’s experience with the Sydney system Open
The current findings supported the preferential use of US-FNAC over US-FNNAC in routine clinical practice for lymph node evaluation, particularly for nodes measuring 5.1-15.0 mm. For lymphadenopathies ≤5.0 mm, additional tests were require…
View article: The application of radiomics in the diagnosis and evaluation of cognitive impairment related to neurological diseases
The application of radiomics in the diagnosis and evaluation of cognitive impairment related to neurological diseases Open
Cognitive impairment (CI) is common, with diverse underlying causes, symptoms, and imaging features. It often leads to disability and loss of independence. Early diagnosis and assessment of CI are crucial for the prognosis improvement. Con…
View article: Prevalence, associated factors, and short-term impact of central sensitization in high-altitude patients undergoing total knee arthroplasty
Prevalence, associated factors, and short-term impact of central sensitization in high-altitude patients undergoing total knee arthroplasty Open
Purpose Central sensitization (CS) plays a critical role in prolonged pain and poor outcomes after total knee arthroplasty (TKA), but its prevalence and impact in high-altitude populations remain unexplored. This study aims to examine the …
View article: Single-cell RNA sequencing dissects the immunosuppressive signatures in Helicobacter pylori-infected human gastric ecosystem
Single-cell RNA sequencing dissects the immunosuppressive signatures in Helicobacter pylori-infected human gastric ecosystem Open
View article: Machine learning-based risk prediction model for pertussis in children: a multicenter retrospective study
Machine learning-based risk prediction model for pertussis in children: a multicenter retrospective study Open
View article: CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis
CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis Open
View article: The long-term efficacy of imatinib with hepatic resection or other local treatment for gastrointestinal stromal tumours liver metastases: a retrospective cohort study
The long-term efficacy of imatinib with hepatic resection or other local treatment for gastrointestinal stromal tumours liver metastases: a retrospective cohort study Open
Background: The liver is the most common site of metastasis from gastrointestinal stromal tumors (GISTs). The authors aimed to evaluate imatinib (IM) combined with hepatic resection (HR) or other local treatments such as radiofrequency abl…
View article: Postoperative adjuvant immunotherapy for high-risk hepatocellular carcinoma patients
Postoperative adjuvant immunotherapy for high-risk hepatocellular carcinoma patients Open
Background and aim Standardized approach to postoperative adjuvant therapy for hepatocellular carcinoma (HCC) remains elusive. This study endeavors to examine the effects of postoperative PD-1 adjuvant therapy on the short-term and long-te…
View article: Evaluation of the diagnostic efficacy of liquid-based cytology obtained via percutaneous ultrasound-guided fine-needle aspiration for pancreatic masses: a large tertiary center’s 8-year experience
Evaluation of the diagnostic efficacy of liquid-based cytology obtained via percutaneous ultrasound-guided fine-needle aspiration for pancreatic masses: a large tertiary center’s 8-year experience Open
View article: Accessory Breast Cancer of the Right Axillary Region: A Case Report and Review of Management
Accessory Breast Cancer of the Right Axillary Region: A Case Report and Review of Management Open
Accessory breast tissue results from failure of the embryologic mammary ridge, also known as the milk line, to involute. Because of the low incidence of these cases in the population and the lack of a fixed location for the tumor to occur.…
View article: METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells
METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells Open
METTL14 (methyltransferase-like 14) is an RNA-binding protein that partners with METTL3 to mediate N6-methyladenosine (m6A) methylation. Recent studies identified a function for METTL3 in heterochromatin in mouse embr…
View article: Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy
Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy Open
Ferroptosis is an evolutionarily conserved form of regulated cell death triggered by iron-dependent phospholipid peroxidation. Ferroptosis contributes to the maintenance of tissue homeostasis under physiological conditions while its aberra…
View article: Dysregulated TET Family Genes and Aberrant 5mC Oxidation in Breast Cancer: Causes and Consequences
Dysregulated TET Family Genes and Aberrant 5mC Oxidation in Breast Cancer: Causes and Consequences Open
DNA methylation (5-methylcytosine, 5mC) was once viewed as a stable epigenetic modification until Rao and colleagues identified Ten-eleven translocation 1 (TET1) as the first 5mC dioxygenase in 2009. TET family genes (including TET1, TET2,…
View article: Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells
Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells Open
Aberrant DNA methylation is an epigenetic hallmark of malignant tumours. The DNA methylation level is regulated by not only DNA methyltransferases (DNMTs) but also Ten-Eleven Translocation (TET) family proteins. However, the exact role of …
View article: Expression pattern and regulatory effect of lysine-specific demethylase 2A gene in clear cell renal cell carcinoma
Expression pattern and regulatory effect of lysine-specific demethylase 2A gene in clear cell renal cell carcinoma Open
View article: Echocardiographic left ventricular geometry profiles for prediction of stroke, coronary heart disease and all-cause mortality in the Chinese community: a rural cohort population study
Echocardiographic left ventricular geometry profiles for prediction of stroke, coronary heart disease and all-cause mortality in the Chinese community: a rural cohort population study Open
View article: Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis
Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis Open
Warburg effect reflects that tumor cells tend to generate energy by aerobic glycolysis rather than oxidative phosphorylation (OXPHOS), thus promoting the development of malignant tumors. As a kind of non-coding RNA, circular RNA (circRNA) …
View article: Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells
Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells Open
Aberrant DNA methylation is an epigenetic hallmark of malignant tumours. The DNA methylation level is regulated by not only DNA methyltransferases (DNMTs) but also Ten-Eleven Translocation (TET) family proteins. However, the exact role of …
View article: Tumor suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells
Tumor suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells Open
Aberrant DNA methylation is an epigenetic hallmark of malignant tumors. The DNA methylation level is regulated by not only DNA methyltransferases (DNMTs) but also Ten-Eleven Translocation (TET) family proteins. However, the exact role of <…
View article: SOX17 and PAX8 constitute an actionable lineage-survival transcriptional complex in ovarian cancer
SOX17 and PAX8 constitute an actionable lineage-survival transcriptional complex in ovarian cancer Open
Objective: This study was aimed to investigate the patient's characteristics and histopathologic findings of risk-reducing salpingo-oophorectomy (RRSO) conducted in Asan Medical Center.Methods: We retrospectively analyzed the medical recor…
View article: The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is the most common type of dementia, and patients with advanced AD frequently lose the ability to identify family members. The fusiform gyrus (FUS) of the brain is critical in facial recognition. However…
View article: Thinprep® test versus conventional smear for the detection of pancreatic neoplasms after percutaneous ultrasound-guided fine-needle aspiration biopsy
Thinprep® test versus conventional smear for the detection of pancreatic neoplasms after percutaneous ultrasound-guided fine-needle aspiration biopsy Open
Background Few studies have defined the diagnostic value of ThinPrep pap test (a liquid-based cytology) for pancreatic samples obtained by percutaneous fine-needle aspiration (FNA). This study aimed to compare the efficacy of ThinPrep cyto…
View article: Additional file 10 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
Additional file 10 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease Open
Additional file 10: Table S9. ST9_Known_AD_risk_factors.txt. All computer codes used in our analyses were deposited in GitHub.
View article: Additional file 3 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
Additional file 3 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease Open
Additional file 3: Table S2. ST2_Top_DEG_in_heatmap_AD-risk-factor_TF.xlsx.
View article: Additional file 7 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
Additional file 7 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease Open
Additional file 7: Table S6. ST6_STRING_output_interactions.xlsx.
View article: Additional file 6 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
Additional file 6 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease Open
Additional file 6: Table S5. ST5_details_of_neurons_differentiation_protocols.xlsx.
View article: Additional file 4 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
Additional file 4 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease Open
Additional file 4: Table S3. ST3_Venn_common_genes_in_FUS_and_AD-Ns.xlsx.
View article: Additional file 5 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
Additional file 5 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease Open
Additional file 5: Table S4. ST4_common_up_down_expressed_genes_in_FUS_and_AD-Ns.xlsx.
View article: Additional file 9 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
Additional file 9 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease Open
Additional file 9: Table S8. ST8_Samples_info.xlsx.
View article: Additional file 2 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
Additional file 2 of The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease Open
Additional file 2: Table S1. ST1_DEG_of_4_brain_reigons.xls.