Explanipedia

Enhancing lymph node diagnosis: integrating deep learning with endoscopic ultrasonography: a retrospective study in China Open

Zijun Fan, Zhenyun Gong, Run Xian Bao, Qinkai Li, Wei Wu , et al. · 2025

Background/Aims: Lymphadenopathy presents diagnostic challenges, particularly for the mediastinal and intra-abdominal lymph nodes (LNs). Endoscopic ultrasonography (EUS) has emerged as a tool for LN detection; however, its accuracy varies.…

Refining δ15N isotopic fingerprints of local NO for accurate source identification of nitrate in PM2.5 Open

Hao Xiao, Qinkai Li, Shiyuan Ding, Wenjing Dai, Gaoyang Cui , et al. · 2025

Stable nitrogen isotopic composition (δ¹⁵N) has proven to be a valuable tool for identifying sources of nitrates (NO₃^-) in PM_2.5. However, the absence of a systematic study on the δ¹⁵N…

Quantitative proteomic and glycoproteomic analysis identifies CLCA1, FBN1, and FGB as potential biomarkers for ulcerative colitis Open

Xiaotong Wang, Siyue Bo, Qinkai Li, Wentong Li, Longjiang Xu , et al. · 2025

Ulcerative colitis (UC), a prevalent inflammatory bowel disease (IBD), significantly increases the risk of colorectal cancer with prolonged duration. CLCA1, FGB, and FBN1 show promise as UC markers.

First report of opportunistic screening for nasopharyngeal carcinoma by gastroscopy Open

Jialiang Huang, Qinkai Li, Wei Wu · 2024

A 45-year-old woman presented at our hospital with epigastric pain. Gastroscopy was undertaken, but before the gastroscope was inserted into her esophagus, her nasopharynx was examined. This examination revealed a 1.8-cm lesion ([Video 1])…

Technical note: Refining δ <sup>15</sup> N isotopic fingerprints of local NOx for accurate source identification of nitrate in PM <sub>2.5</sub> Open

Hao Xiao, Qinkai Li, Shiyuan Ding, Wenjing Dai, Gaoyang Cui , et al. · 2024

Stable nitrogen isotopic composition (δ15N) has proven to be a valuable tool for identifying sources of nitrates (NO3–) in PM2.5. However, the absence of a systematic study on the δ15N values of domestic NOx sources hinders accurate identi…

Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation Open

Xiaoquan Wang, Youqiao Wang, Anqi Cao, Qinhong Luo, Daoyuan Chen , et al. · 2023

Cyclic GMP-AMP synthase (cGAS) is an essential sensor of aberrant cytosolic DNA for initiating innate immunity upon invading pathogens and cellular stress, which is considered as a potential drug target for autoimmune and autoinflammatory …

ImageReward: Learning and Evaluating Human Preferences for Text-to-Image Generation Open

Jiazheng Xu, Xiao Liu, Yuchen Wu, Yuxuan Tong, Qinkai Li , et al. · 2023

We present a comprehensive solution to learn and improve text-to-image models from human preference feedback. To begin with, we build ImageReward -- the first general-purpose text-to-image human preference reward model -- to effectively en…

Identification and Contribution of Potential Sources to Atmospheric Lead Pollution in a Typical Megacity: Insights from Isotope Analysis and the Bayesian Mixing Model Open

Wenjing Dai, Yucong Fu, Xiaodong Li, Shiyuan Ding, Qinkai Li , et al. · 2023

Using Stable Sulfur Isotope to Trace Sulfur Oxidation Pathways during the Winter of 2017–2019 in Tianjin, North China Open

Shiyuan Ding, Yingying Chen, Qinkai Li, Xiaodong Li · 2022

After the implementation of the Coal Replacing Project (CRP) in the northern parts of China in 2017, its effect on PM2.5 composition is still unclear. In the study, water-soluble ionic components (WSICs) and stable sulfur isotope ratios (δ…

A LiNbO3 Integrated Optics Sensor for Measurement of Pulsed Current Open

Jiahong Zhang, Qinkai Li, Yingna Li, Jing Zhang · 2022

A LiNbO3 integrated optics sensor fusing with an optical waveguide Mache–Zehnder interferometer (MZI), a loop-antenna, and a segmented electrode has been proposed, designed, and fabricated for the measurement of pulsed current. The experim…

Large contributions of biogenic and anthropogenic sources to fine organic aerosols in Tianjin, North China Open

Yanbing Fan, Cong-Qiang Liu, Linjie Li, Lujie Ren, Hong Ren , et al. · 2020

In order to better understand the molecular composition and sources of organic aerosols in Tianjin, a coastal megacity in North China, ambient fine aerosol (PM2.5) samples were collected on a day/night basis from November to December 2016 …

Large contributions of biogenic and anthropogenic sources to fine organic aerosols in Tianjin, North China Open

Yanbing Fan, Cong‐Qiang Liu, Linjie Li, Lujie Ren, Hong Ren , et al. · 2019

In order to better understand the molecular composition and sources of organic aerosols in Tianjin, a coastal megacity in North China, ambient fine aerosol (PM2.5) samples were collected on a day/night basis during November–December 2016 a…

Supplementary material to "Large contributions of biogenic and anthropogenic sources to fine organic aerosols in Tianjin, North China" Open

Yanbing Fan, Cong‐Qiang Liu, Linjie Li, Lujie Ren, Hong Ren , et al. · 2019

A table of chemical components detected in this studyl A table of ratios among organic compounds in this study l Two tables of linear correlation coefficients between saccharides in winter and summer l Two tables of linear correlation coef…

STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity Open

Jianwen Pei, Yibo Zhang, Qinhong Luo, Wenlv Zheng, Wanxuan Li , et al. · 2019

Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a key regulator in innate immunity and has emerged as a promising drug target in cancer treatment, but the utility of this pathway in therapeutic development …

Seasonal Characteristics of Sulfate and Nitrate in Size-segregated Particles in Ammonia-poor and -rich Atmospheres in Chengdu, Southwest China Open

Qinkai Li, Zhou Yang, Xiaodong Li, Shiyuan Ding, Feng Du · 2019

In order to determine the seasonal characteristics of water-soluble inorganic ions (WSIIs) in aerosols in urban atmospheres, size-segregated particulate matter (PM) samples were collected over a one-year period from February 2012 to Januar…

Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8 Open

Chen Shen, Jianwen Pei, Xiaomin Guo, Lu Zhou, Qinkai Li , et al. · 2018

Caspase-8 is an apoptotic protease that is activated by a proximity-induced dimerization mechanism within the death-inducing signaling complex (DISC). The death effector domain (DED) of caspase-8 is involved in protein-protein interactions…

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation Open

Yiming Xu, Yong Wang, Siyuan Yan, Qiuhua Yang, Yaqi Zhou , et al. · 2017

The molecular mechanisms underlying vascular inflammation and associated inflammatory vascular diseases are not well defined. Here we show that endothelial intracellular adenosine and its key regulator adenosine kinase (ADK) play important…

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis Open

Zhiping Liu, Siyuan Yan, Jiaojiao Wang, Yiming Xu, Yong Wang , et al. · 2017

Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis Open

Yiming Xu, Yong Wang, Siyuan Yan, Yaqi Zhou, Qiuhua Yang , et al. · 2017

The nucleoside adenosine is a potent regulator of vascular homeostasis, but it remains unclear how expression or function of the adenosine‐metabolizing enzyme adenosine kinase (ADK) and the intracellular adenosine levels influence angiogen…

Qinkai Li YOU? Author Swipe