Kai Shi Lim
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View article: Precision Stratification: Kinase Assay in Asian <i>LRRK2</i> Risk Carriers and Idiopathic Parkinson Disease
Precision Stratification: Kinase Assay in Asian <i>LRRK2</i> Risk Carriers and Idiopathic Parkinson Disease Open
Importance LRRK2 kinase inhibition is one of the most promising therapeutic strategies in Parkinson’s disease (PD), yet understanding of kinase activity in the Asian-prevalent p.G2385R and p.R1628P variants, each affecting 5–10% of PD pati…
View article: The <i>LRRK2</i> p.A419V variant associates with risk of Parkinson’s disease in the East Asian population and an evaluation on age of onset
The <i>LRRK2</i> p.A419V variant associates with risk of Parkinson’s disease in the East Asian population and an evaluation on age of onset Open
Common and rare variants in LRRK2 influence Parkinson’s disease (PD) risk across diverse populations. We investigated the p.A419V variant across multiple ancestry cohorts comprising over 200,000 individuals. In cases of East Asian ancestry…
View article: Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant
Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant Open
LRRK2 -related Parkinson’s disease ( LRRK2 -PD) is the most frequent form of monogenic PD worldwide, with important therapeutic opportunities, exemplified by the advancement in LRRK2 kinase inhibition studies/trials. However, many LRRK2 va…
View article: Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant
Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant Open
LRRK2-related Parkinson’s disease (LRRK2-PD) is the most frequent form of monogenic PD worldwide, with important therapeutic opportunities, exemplified by the advancement in LRRK2 kinase inhibition studies/trials. However, many LRRK2 varia…