Shuxiang Li
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View article: Uncovering allosteric communication in cancer-related histone mutations
Uncovering allosteric communication in cancer-related histone mutations Open
Background Histone mutations have been implicated in various cancers, but their mechanistic effects on chromatin dynamics remain largely unexplored. Aim To investigate how allosteric communication influences the functional outcomes of canc…
View article: Cancer histone mutations impact protein binding and DNA repair with possible links to genomic instability
Cancer histone mutations impact protein binding and DNA repair with possible links to genomic instability Open
Histones are key epigenetic factors that regulate the accessibility and compaction of eukaryotic genomes, affecting DNA replication and repair, and gene expression. Recent studies have demonstrated that histone missense mutations can pertu…
View article: ALG13 Deficiency and Epilepsy-Related Cognitive Impairment: Role of the DDIT4-Mediated PI3K/AKT/mTOR Pathway
ALG13 Deficiency and Epilepsy-Related Cognitive Impairment: Role of the DDIT4-Mediated PI3K/AKT/mTOR Pathway Open
ALG13 deficiency results in cognitive impairment in mice, potentially mediated by dysregulation of the DDIT4-PI3K/AKT/mTOR signaling pathway.
View article: Building Nucleosome Positioning Maps: Discovering Hidden Gems
Building Nucleosome Positioning Maps: Discovering Hidden Gems Open
Nucleosomes serve as fundamental units of chromatin packaging and play a crucial role as central hubs in epigenetic regulation. Their positions throughout the genome are not random and follow certain patterns, influenced by DNA sequence, h…
View article: Cover Image, Volume 15, Issue 3
Cover Image, Volume 15, Issue 3 Open
The cover image is based on the article Building Nucleosome Positioning Maps: Discovering Hidden Gems by Anna Panchenko et al., https://doi.org/10.1002/wcms.70029 . image
View article: Giant Anomalous Hall Effect in Kagome Nodal Surface Semimetal Fe$_3$Ge
Giant Anomalous Hall Effect in Kagome Nodal Surface Semimetal Fe$_3$Ge Open
It is well known that the intrinsic anomalous Hall effect (AHE) arises from the integration of the non-zero Berry curvature (BC), conventionally observed in the Dirac/Weyl and nodal-line semimetals. Moreover, nodal surface semimetals are e…
View article: Patients with AMA/anti-sp100/anti-gp210 Positivity and Cholestasis Can Manifest Conditions Beyond Primary Biliary Cholangitis
Patients with AMA/anti-sp100/anti-gp210 Positivity and Cholestasis Can Manifest Conditions Beyond Primary Biliary Cholangitis Open
PBC-specific antibodies, along with elevated ALP and GGT levels, may occur in various non-PBC diseases. Etiological treatments may improve or even resolve cholestatic biochemistry. For these patients, initiating etiological treatment rathe…
View article: Clinicopathologic Features of a Rare and Underrecognized Variant of Early-stage Primary Biliary Cholangitis With Ductopenia
Clinicopathologic Features of a Rare and Underrecognized Variant of Early-stage Primary Biliary Cholangitis With Ductopenia Open
Primary biliary cholangitis (PBC) with early cholestasis and extensive bile duct loss but no significant fibrosis or cirrhosis is rare and underrecognized. We aimed to clarify the clinicopathology features and prognosis of these variants o…
View article: The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications
The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications Open
As a complicated and heterogeneous condition, breast cancer (BC) has posed a tremendous public health challenge across the world. Recent studies have uncovered the crucial effect of human microbiota on various perspectives of health and di…
View article: Construction and validation of prognostic model for colorectal mucinous adenocarcinoma patients and identification of a new prognosis related gene FAM174B
Construction and validation of prognostic model for colorectal mucinous adenocarcinoma patients and identification of a new prognosis related gene FAM174B Open
We have developed and validated a four-gene prognostic model to predict the survival of MAC. Additionally, we found that FAM174B might correlate with mucin production in MAC.
View article: Two-loop planar master integrals for NNLO QCD corrections to W-pair production in quark-antiquark annihilation
Two-loop planar master integrals for NNLO QCD corrections to W-pair production in quark-antiquark annihilation Open
The planar two-loop scalar Feynman integrals contributing to the massive NNLO QCD corrections for $W$-boson pair production via quark-antiquark annihilation can be classified into three family branches, each of which is reduced to a distin…
View article: Bivalent chromatin accommodates survivin and BRG1/SWI complex to activate DNA damage response in CD4+ cells
Bivalent chromatin accommodates survivin and BRG1/SWI complex to activate DNA damage response in CD4+ cells Open
Background Bivalent regions of chromatin (BvCR) are characterized by trimethylated lysine 4 (H3K4me3) and lysine 27 on histone H3 (H3K27me3) deposition which aid gene expression control during cell differentiation. The role of BvCR in post…
View article: Interpretable deep residual network uncovers nucleosome positioning and associated features
Interpretable deep residual network uncovers nucleosome positioning and associated features Open
Nucleosomes represent elementary building units of eukaryotic chromosomes and consist of DNA wrapped around a histone octamer flanked by linker DNA segments. Nucleosomes are central in epigenetic pathways and their genomic positioning is a…
View article: The Role and Therapeutic Potential of Pyroptosis in Colorectal Cancer: A Review
The Role and Therapeutic Potential of Pyroptosis in Colorectal Cancer: A Review Open
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. The unlimited proliferation of tumor cells is one of the key features resulting in the malignant development and progression of CRC. Consequently, …
View article: Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway Open
Osteoarthritis (OA) is a common degenerative joint disease in the elderly, while oxidative stress-induced chondrocyte degeneration plays a key role in the pathologic progression of OA. One possible reason is that the expression of nuclear …
View article: Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects
Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects Open
Diphthamide is a modified histidine residue unique for eukaryotic translation elongation factor 2 (eEF2), a key ribosomal protein. Loss of this evolutionarily conserved modification causes developmental defects through unknown mechanisms. …
View article: SURVIVIN IN SYNERGY WITH BAF/SWI COMPLEX BINDS BIVALENT CHROMATIN REGIONS AND ACTIVATES DNA DAMAGE RESPONSE IN CD4+ T CELLS
SURVIVIN IN SYNERGY WITH BAF/SWI COMPLEX BINDS BIVALENT CHROMATIN REGIONS AND ACTIVATES DNA DAMAGE RESPONSE IN CD4+ T CELLS Open
This study explores a regulatory role of oncoprotein survivin on the bivalent regions of chromatin (BvCR) characterized by concomitant deposition of trimethylated lysine of histone H3 at position 4 (H3K4me3) and 27 (H3K27me3). Intersect be…
View article: Genome-wide Nucleosome Positioning and Associated Features uncovered with Interpretable Deep Residual Networks
Genome-wide Nucleosome Positioning and Associated Features uncovered with Interpretable Deep Residual Networks Open
Nucleosomes represent elementary building units of eukaryotic chromosomes and consist of DNA wrapped around a histone octamer flanked by linker DNA segments. Nucleosomes are central in epigenetic pathways and their genomic positioning is a…
View article: Mixed QCD-EW corrections to $W$-pair production at electron-positron colliders
Mixed QCD-EW corrections to $W$-pair production at electron-positron colliders Open
The discrepancy between the CDF measurement and the Standard Model theoretical prediction for the $W$-boson mass underscores the importance of conducting high-precision studies on the $W$ boson, which is one of the predominant objectives o…
View article: Add-on immunosuppressive therapy may benefit selected patients with primary biliary cholangitis and autoimmune phenomena
Add-on immunosuppressive therapy may benefit selected patients with primary biliary cholangitis and autoimmune phenomena Open
Background: Mildly elevated levels of transaminase and/or immunoglobulin G (IgG) are common in patients with primary biliary cholangitis (PBC). It is still unclear whether adding immunosuppressive therapy to ursodeoxycholic acid (UDCA) ben…
View article: Mixed $\text{QCD} \otimes \text{EW}$ corrections to charged Higgs pair production in THDM at electron-positron colliders
Mixed $\text{QCD} \otimes \text{EW}$ corrections to charged Higgs pair production in THDM at electron-positron colliders Open
We calculate the two-loop mixed QCD$\otimes$EW corrections for the charged Higgs boson pair production within the framework of four types of Two Higgs Doublet Models (THDMs) with the $Z_2$ symmetry. We analyze in detail the dependences of …
View article: Next-to-next-to-leading order $\text{QCD} \otimes \text{EW}$ corrections to $Z$-boson pair production at electron-positron colliders
Next-to-next-to-leading order $\text{QCD} \otimes \text{EW}$ corrections to $Z$-boson pair production at electron-positron colliders Open
We present a comprehensive analytic calculation of the next-to-next-to-leading order $\text{QCD} \otimes \text{EW}$ corrections to $Z$-boson pair production at electron-positron colliders. The two-loop master integrals essential to this ca…
View article: Editorial: Pathogen-host interaction in the development of viral hepatitis
Editorial: Pathogen-host interaction in the development of viral hepatitis Open
EDITORIAL article Front. Cell. Infect. Microbiol., 21 November 2023Sec. Clinical Microbiology Volume 13 - 2023 | https://doi.org/10.3389/fcimb.2023.1333470
View article: Impact of bariatric surgery on glucose and lipid metabolism and liver and kidney function in food-induced obese diabetic rats
Impact of bariatric surgery on glucose and lipid metabolism and liver and kidney function in food-induced obese diabetic rats Open
The incidence of type 2 diabetes mellitus is growing in epidemic proportions and has become one of the most critical public health concerns. Cardiovascular complications associated with diabetes are the leading cause of morbidity and morta…
View article: DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis
DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis Open
Mitochondria are vital for energy production and redox homeostasis, yet knowledge of relevant mechanisms remains limited. Here, through a genome-wide CRISPR-Cas9 knockout screening, we have identified DMT1 as a major regulator of mitochond…