Kun Fang
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View article: From residual risk to precision intervention: the evolving role of minimal residual disease in breast cancer management
From residual risk to precision intervention: the evolving role of minimal residual disease in breast cancer management Open
Breast cancer mortality is driven predominantly by metastasis, which affects 20–30% of patients with early-stage disease despite guideline-directed therapies. Because conventional imaging modalities currently lack sensitivity…
View article: Metabolomic changes associated with treatment response of neoadjuvant chemotherapy with TEC regimen in HER2-negative breast cancer
Metabolomic changes associated with treatment response of neoadjuvant chemotherapy with TEC regimen in HER2-negative breast cancer Open
Introduction This study aimed to characterize time-dependent metabolic alterations and identify metabolites associated with treatment response in HER2-negative breast cancer patients undergoing neoadjuvant chemotherapy (NAC) with the TEC r…
View article: Critical appraisal of a machine learning model for predicting internal mammary lymph node metastasis in breast cancer
Critical appraisal of a machine learning model for predicting internal mammary lymph node metastasis in breast cancer Open
View article: Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation
Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation Open
Aim To explore periodontitis‐induced changes in the femoral artery microbiota and their impact on the immune system, seeking to clarify the mechanisms underlying the link between periodontitis and peripheral arterial diseases (PADs). Mater…
View article: Elucidating the causal effects of plasma metabolites on breast cancer from multiple perspectives
Elucidating the causal effects of plasma metabolites on breast cancer from multiple perspectives Open
Background: Early studies found common metabolic reprogramming in breast cancer. However, the causal effects of plasma metabolites on breast cancer remain unclear. Methods: Mendelian Randomization (MR) and Linkage Disequilibrium Score (LDS…
View article: Letter to editor about artificial intelligence predicts multiclass molecular signatures and subtypes directly from breast cancer histology: a multicenter retrospective study
Letter to editor about artificial intelligence predicts multiclass molecular signatures and subtypes directly from breast cancer histology: a multicenter retrospective study Open
View article: Elevated TOR1B expression predicts poor survival outcomes in patients with breast cancer
Elevated TOR1B expression predicts poor survival outcomes in patients with breast cancer Open
View article: A study of the influence of short-term low-air pressure intervention on air-void characteristic and ion transport properties
A study of the influence of short-term low-air pressure intervention on air-void characteristic and ion transport properties Open
View article: SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo
SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo Open
Metastatic cancer, the primary cause of cancer mortality, frequently exhibits heightened dependence on certain transcription factors (TFs), which serve as master regulators of oncogenic signaling yet are often untargetable by small molecul…
View article: [Retracted] lncRNA FGD5‑AS1 promotes breast cancer progression by regulating the hsa‑miR‑195‑5p/NUAK2 axis
[Retracted] lncRNA FGD5‑AS1 promotes breast cancer progression by regulating the hsa‑miR‑195‑5p/NUAK2 axis Open
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the cell migration and invasion assay data shown in Fig. 2C and D on p. 4 were strikingly similar to data that had alread…
View article: Facile synthesis of carbon nitride nanotube confined nano Fe0 for boosting activation of peroxymonosulfate towards tetracycline removal
Facile synthesis of carbon nitride nanotube confined nano Fe0 for boosting activation of peroxymonosulfate towards tetracycline removal Open
View article: Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies
Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies Open
MSC-Exos reveal significant therapeutic potential for IS, with evidence supporting their efficacy in reducing infarct size and enhancing functional recovery in preclinical rodent models. These findings pave the way for further research and…
View article: FAM49B suppresses ovarian cancer cell growth through regulating MAPK signaling
FAM49B suppresses ovarian cancer cell growth through regulating MAPK signaling Open
Recently, the family with sequence similarity 49 member B (FAM49B, also called CYRI-B) has garnered attention as a new target in cancer development. FAM49B is upregulated in ovarian cancer tissues; however, its role and mechanism in ovaria…
View article: Dietary Palmitic Acid Drives a Palmitoyltransferase ZDHHC15‐YAP Feedback Loop Promoting Tumor Metastasis
Dietary Palmitic Acid Drives a Palmitoyltransferase ZDHHC15‐YAP Feedback Loop Promoting Tumor Metastasis Open
Elevated uptake of saturated fatty acid palmitic acid (PA) is associated with tumor metastasis; however, the precise mechanisms remain partially understood, hindering the development of therapy for PA‐driven tumor metastasis. The Hippo–Yes…
View article: LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review
LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review Open
View article: Pan-cancer landscape of disulfidptosis across human tumors
Pan-cancer landscape of disulfidptosis across human tumors Open
View article: CD70 is a potential prognostic marker and significantly regulates cellular function in diffuse large B-cell lymphoma
CD70 is a potential prognostic marker and significantly regulates cellular function in diffuse large B-cell lymphoma Open
Extensive research has demonstrated that dysregulation of costimulatory molecule expression plays a pivotal role in cancer biology. However, the impact of intratumoral CD70 on the initiation, progression, and immune response in diffuse lar…
View article: A nomogram to predict mortality in patients with severe fever with thrombocytopenia syndrome
A nomogram to predict mortality in patients with severe fever with thrombocytopenia syndrome Open
View article: Exploring the microRNA-mRNA regulatory network associated with solasonine in bladder cancer
Exploring the microRNA-mRNA regulatory network associated with solasonine in bladder cancer Open
A regulatory network, including solasonine, miRNAs, and mRNAs related to BC, was constructed. This network provides extensive insights into the molecular regulatory mechanisms that underlie the anti-cancer efficacy of solasonine in BC.
View article: Disulfidptosis heterogeneity in breast cancer uncovers PTTG1IP as an actionable therapeutic target
Disulfidptosis heterogeneity in breast cancer uncovers PTTG1IP as an actionable therapeutic target Open
View article: Heterogeneity of anoikis in triple-negative breast cancer subtyping and therapeutic implications
Heterogeneity of anoikis in triple-negative breast cancer subtyping and therapeutic implications Open
View article: Facile Synthesis of Carbon Nitride Nanotube Embedded Fe0 for Boosting Activation of Peroxymonosulfate Towards Tetracycline Degradation in Water
Facile Synthesis of Carbon Nitride Nanotube Embedded Fe0 for Boosting Activation of Peroxymonosulfate Towards Tetracycline Degradation in Water Open
View article: Cold-inducible RNA-binding protein induces inflammatory responses via NF-κB signaling pathway in normal human bronchial epithelial cells infected with streptococcus pneumoniae
Cold-inducible RNA-binding protein induces inflammatory responses via NF-κB signaling pathway in normal human bronchial epithelial cells infected with streptococcus pneumoniae Open
Background Community-acquired pneumonia is a significant cause of morbidity and mortality worldwide, with substantial clinical implications that warrant further investigation and intervention. The invasion of Streptococcus pneumoniae (S. p…
View article: Prognostic value of Th1/Th2/Th17-related cytokines in severe pneumonia
Prognostic value of Th1/Th2/Th17-related cytokines in severe pneumonia Open
Background To investigate the value of Th1/Th2/Th17-related cytokine expression in the prognosis of patients with severe pneumonia (SP). Methods The observational group consisted of 106 patients diagnosed with severe pneumonia who were adm…
View article: Carbonic anhydrase IX inhibitor S4 triggers release of DAMPs related to immunogenic cell death in glioma cells via endoplasmic reticulum stress pathway
Carbonic anhydrase IX inhibitor S4 triggers release of DAMPs related to immunogenic cell death in glioma cells via endoplasmic reticulum stress pathway Open
View article: The application of clinical variable-based nomogram in predicting overall survival in malignant phyllodes tumors of the breast
The application of clinical variable-based nomogram in predicting overall survival in malignant phyllodes tumors of the breast Open
Background: We aimed to explore prognostic risk factors in patients with malignant phyllodes tumors (PTs) of the breast and construct a survival prediction model. Methods: The Surveillance, Epidemiology, and End Results database was used t…
View article: Disseminated varicella-zoster virus infection in an aplastic anemia- paroxysmal nocturnal hemoglobinuria syndrome patient: A case report
Disseminated varicella-zoster virus infection in an aplastic anemia- paroxysmal nocturnal hemoglobinuria syndrome patient: A case report Open
Background Varicella-zoster virus (VZV) is a common and widespread human-restricted pathogen. It is famous for its dermatological manifestations, such as varicella and herpes zoster. Patients with aplastic anemia-paroxysmal nocturnal hemog…
View article: Effect of magnetic field correlation length on the gamma-ray pulsar halo morphology under anisotropic diffusion
Effect of magnetic field correlation length on the gamma-ray pulsar halo morphology under anisotropic diffusion Open
Anisotropic diffusion is one of the potential interpretations for the morphology of the Geminga pulsar halo. It interprets the observed slow-diffusion phenomenon through a geometric effect, assuming the mean magnetic field direction around…
View article: Comprehensive multimodal management of borderline resectable pancreatic cancer: Current status and progress
Comprehensive multimodal management of borderline resectable pancreatic cancer: Current status and progress Open
Borderline resectable pancreatic cancer (BRPC) is a complex clinical entity with specific biological features. Criteria for resectability need to be assessed in combination with tumor anatomy and oncology. Neoadjuvant therapy (NAT) for BRP…
View article: Carbonic anhydrase IX inhibitor S4 triggers immunogenic cell death in glioma cells via endoplasmic reticulum stress pathway
Carbonic anhydrase IX inhibitor S4 triggers immunogenic cell death in glioma cells via endoplasmic reticulum stress pathway Open
Background Immunogenic cell death (ICD), which releases danger-associated molecular patterns (DAMP) that induce potent anticancer immune response, has emerged as a key component of therapy-induced anti-tumor immunity. The aim of this work …