Kai Yang
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View article: Correction: Nanoliposomal PD-1 antagonist target tumor-draining lymph nodes to revitalize T cells and improve anti-tumor effect in hepatocellular carcinoma
Correction: Nanoliposomal PD-1 antagonist target tumor-draining lymph nodes to revitalize T cells and improve anti-tumor effect in hepatocellular carcinoma Open
View article: WATER TEMPERATURE ON GROWTH AND LIPID METABOLISM IN CHINESE MANDARIN FISH
WATER TEMPERATURE ON GROWTH AND LIPID METABOLISM IN CHINESE MANDARIN FISH Open
View article: Source-free cross-modality medical image synthesis with diffusion priors
Source-free cross-modality medical image synthesis with diffusion priors Open
Cross-modality medical image synthesis plays a critical role in enabling comprehensive multi-modal diagnosis and treatment. However, existing methods are constrained by their reliance on paired or unpaired source-target data, limiting scal…
View article: Cholesterol Flux Rewiring through LDLR Palmitoylation Establishes a Mitochondrial Shield and Immune Desert in Radioresistant Tumors
Cholesterol Flux Rewiring through LDLR Palmitoylation Establishes a Mitochondrial Shield and Immune Desert in Radioresistant Tumors Open
View article: Nanoliposomal PD-1 antagonist target tumor-draining lymph nodes to revitalize T cells and improve anti-tumor effect in hepatocellular carcinoma
Nanoliposomal PD-1 antagonist target tumor-draining lymph nodes to revitalize T cells and improve anti-tumor effect in hepatocellular carcinoma Open
View article: Unraveling the oncogenic role of LINC00504 and its interaction with miR-545-3p and ARIHI in hepatocellular carcinoma: novel insights for molecular therapy
Unraveling the oncogenic role of LINC00504 and its interaction with miR-545-3p and ARIHI in hepatocellular carcinoma: novel insights for molecular therapy Open
View article: PLGA-based biocompatible nanoparticles improved anti-breast tumor efficacy of 1,25(OH)2D3 through the SOCS3/STAT3/EMT signaling axis
PLGA-based biocompatible nanoparticles improved anti-breast tumor efficacy of 1,25(OH)2D3 through the SOCS3/STAT3/EMT signaling axis Open
Several studies have demonstrated that active vitamin D (1,25(OH)2D3) can impede the cancerous traits of breast cancer. However, due to the susceptibility of 1,25(OH)2D3 to degradation in the tumor microenvironment, higher doses were requi…
View article: Comparative transcriptome analysis reveals the key role of photosynthetic traits in the formation of differences in photothermal sensitivity in tobacco
Comparative transcriptome analysis reveals the key role of photosynthetic traits in the formation of differences in photothermal sensitivity in tobacco Open
View article: Correction for He et al., “Viral MicroRNAs Targeting Virus Genes Promote Virus Infection in Shrimp <i>In Vivo</i> ”
Correction for He et al., “Viral MicroRNAs Targeting Virus Genes Promote Virus Infection in Shrimp <i>In Vivo</i> ” Open
View article: A new pathogen pattern of acute respiratory tract infections in primary care after COVID-19 pandemic: a multi-center study in southern China
A new pathogen pattern of acute respiratory tract infections in primary care after COVID-19 pandemic: a multi-center study in southern China Open
After the COVID-19 pandemic, the main viral pathogens of ARTIs were unevenly distributed, and less bacterial and atypical pathogens were detected in primary care. The microbiological evidences can optimize the precision diagnosis and treat…
View article: Identifying novel aging-related diagnostic and prognostic models and aging-targeted drugs for sepsis patients
Identifying novel aging-related diagnostic and prognostic models and aging-targeted drugs for sepsis patients Open
Sepsis is defined as a dysfunctional, life-threatening response to infection leading to multiorgan dysfunction and failure. During the past decade, studies have highlighted the relationship between sepsis and aging. However, the role of ag…
View article: High microvessel and lymphatic vessel density predict poor prognosis in patients with esophageal squamous cell carcinoma
High microvessel and lymphatic vessel density predict poor prognosis in patients with esophageal squamous cell carcinoma Open
Background Microangiogenesis and lymphangiogenesis are essential for tumor growth in the tumor microenvironment, contributing to tumor invasion and metastasis. Limited literature exists on these processes in esophageal squamous cell carcin…
View article: Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockade
Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockade Open
Background Immune checkpoint blockade (ICB) has made remarkable achievements, but newly identified armored and cold tumors cannot respond to ICB therapy. The high prevalence of concomitant medications has huge impact on immunotherapeutic r…
View article: Inflammatory bowel disease and breast cancer: A two-sample bidirectional Mendelian randomization study
Inflammatory bowel disease and breast cancer: A two-sample bidirectional Mendelian randomization study Open
There is a correlation between IBD and breast cancer according to previous observational studies. However, so far there is no evidence to support if there is a causal relationship between these 2 diseases. We acquired comprehensive Genome-…
View article: Construction and validation of a necroptosis-related prognostic signature in acute myeloid leukemia
Construction and validation of a necroptosis-related prognostic signature in acute myeloid leukemia Open
Acute myeloid leukemia (AML), an uncommonly low 5-year survival and high mortality rate, is a potentially catastrophic diagnosed subtype of leukemia. The development of new prognostic markers is urgently needed to guide its treatment. Necr…
View article: Research progress in cell therapy for oral diseases: focus on cell sources and strategies to optimize cell function
Research progress in cell therapy for oral diseases: focus on cell sources and strategies to optimize cell function Open
In recent years, cell therapy has come to play an important therapeutic role in oral diseases. This paper reviews the active role of mesenchymal stem cells, immune cell sources, and other cells in oral disorders, and presents data supporti…
View article: MIF as a master regulator in macrophage-induced chemotherapy resistance in esophageal squamous cell carcinoma
MIF as a master regulator in macrophage-induced chemotherapy resistance in esophageal squamous cell carcinoma Open
Backgroun ：Esophageal cancer is insidious, with recurrent metastasis and chemotherapy resistance as primary reasons for treatment failure. Recent interest has focused on the molecular mechanisms of tumor-associated macrophages (TAMs) in th…
View article: High B7-H3 expression with low PD-L1 expression identifies armored-cold tumors in triple-negative breast cancer
High B7-H3 expression with low PD-L1 expression identifies armored-cold tumors in triple-negative breast cancer Open
View article: Investigation of Apparent Digestibility, Caecal Fermentation and Microbiota of Rabbit Fed with Raffinose
Investigation of Apparent Digestibility, Caecal Fermentation and Microbiota of Rabbit Fed with Raffinose Open
View article: The role of endoplasmic reticulum stress-related genes in the diagnosis and subtyping of non-alcoholic fatty liver disease
The role of endoplasmic reticulum stress-related genes in the diagnosis and subtyping of non-alcoholic fatty liver disease Open
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. Chronic activation of endoplasmic reticulum stress (ERS) in hepatocytes may promote the development of NAFLD, yet endoplasmic reticulum stress-related…
View article: Early peripheral perfusion index predicts 28-day outcome in patients with septic shock
Early peripheral perfusion index predicts 28-day outcome in patients with septic shock Open
PPI may have value in predicting 28-day mortality in patients with septic shock.
View article: Preliminary exploration of the correlation between spectral computed tomography quantitative parameters and spread through air spaces in lung adenocarcinoma
Preliminary exploration of the correlation between spectral computed tomography quantitative parameters and spread through air spaces in lung adenocarcinoma Open
Spectral CT quantitative parameters CT100keVa and CT100keVv may be potentially useful parameters in distinguishing the STAS status in LUAD.
View article: Tumor Necrosis Factor Receptor-Associated Factor 6 and Human Cancer: A Systematic Review of Mechanistic Insights, Functional Roles, and Therapeutic Potential
Tumor Necrosis Factor Receptor-Associated Factor 6 and Human Cancer: A Systematic Review of Mechanistic Insights, Functional Roles, and Therapeutic Potential Open
Cancer imposes a substantial burden and its incidence is persistently increasing in recent years. Cancer treatment has been difficult due to its inherently complex nature. The tumor microenvironment (TME) includes a complex interplay of ce…
View article: MAPK8 and CAPN1 as potential biomarkers of intervertebral disc degeneration overlapping immune infiltration, autophagy, and ceRNA
MAPK8 and CAPN1 as potential biomarkers of intervertebral disc degeneration overlapping immune infiltration, autophagy, and ceRNA Open
Background Intervertebral disc degeneration (IDD) is one of the most common health problems in the elderly and a major causative factor in low back pain (LBP). An increasing number of studies have shown that IDD is closely associated with …
View article: CACA guidelines for ultrasound hyperthermia for oral and maxillofacial head and neck squamous cell carcinoma
CACA guidelines for ultrasound hyperthermia for oral and maxillofacial head and neck squamous cell carcinoma Open
Most of the patients with oral and maxillofacial malignancy are in the middle and advanced stages at diagnosis and the incidence rate is increasing in recent years. Chemotherapy alone is difficult to benefit the survival of patients with a…
View article: A new model based on gamma-glutamyl transpeptidase to lymphocyte ratio and systemic immune-inflammation index can effectively predict the recurrence of hepatocellular carcinoma after liver transplantation
A new model based on gamma-glutamyl transpeptidase to lymphocyte ratio and systemic immune-inflammation index can effectively predict the recurrence of hepatocellular carcinoma after liver transplantation Open
Background Liver transplantation (LT) is one of the most effective treatment modalities for hepatocellular carcinoma (HCC), but patients with HCC recurrence after LT always have poor prognosis. This study aimed to evaluate the predictive v…
View article: Roles of E2F family members in the diagnosis and prognosis of head and neck squamous cell carcinoma
Roles of E2F family members in the diagnosis and prognosis of head and neck squamous cell carcinoma Open
View article: Improving the heavy rainfall forecasting using a weighted deep learning model
Improving the heavy rainfall forecasting using a weighted deep learning model Open
Weather forecasting has been playing an important role in socio-economics. However, operational numerical weather prediction (NWP) is insufficiently accurate in terms of precipitation forecasting, especially for heavy rainfalls. Previous w…
View article: Translational Study on the Antiviral Effects of Flavonoids Against Vesicular Stomatitis Virus Infection: From in vitro Cell-Based Evidence to in vivo Regulation of Gut Microbiota and Inflammation
Translational Study on the Antiviral Effects of Flavonoids Against Vesicular Stomatitis Virus Infection: From in vitro Cell-Based Evidence to in vivo Regulation of Gut Microbiota and Inflammation Open
View article: Untargeted metabolomics analysis reveals dynamic changes in co-fermentation with human milk-derived probiotics and Poria cocos
Untargeted metabolomics analysis reveals dynamic changes in co-fermentation with human milk-derived probiotics and Poria cocos Open
Introduction To develop functional foods with traditional medicines and homologous food ingredients as well as human milk-derived probiotics, the co-fermentation process of two probiotics, Lactobacillus plantarum R9 and Lactobacillus gasse…