Kai Zhuang
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View article: Dissecting Causal Relationships Between Gut Microbiota Imbalance, Inflammatory Cytokines, and Structural Connectivity in the Brain: A Mendelian Randomization Study
Dissecting Causal Relationships Between Gut Microbiota Imbalance, Inflammatory Cytokines, and Structural Connectivity in the Brain: A Mendelian Randomization Study Open
Purpose Growing evidence indicates that the imbalances in gut microbiota influence brain structural connectivity, a key component of the microbiota‐gut‐brain axis. However, a deeper understanding of this complex bidirectional relationship …
View article: Unveiling the impact of interferon genes on the immune microenvironment of triple-negative breast cancer: identification of therapeutic targets
Unveiling the impact of interferon genes on the immune microenvironment of triple-negative breast cancer: identification of therapeutic targets Open
Objective Triple-negative breast cancer (TNBC), a classic subtype of breast cancer, is challenging to treat due to the lack of drug-targeting receptors. This study aims to explore interferon-related prognostic molecular biomarkers in TNBC …
View article: Effects of probiotics, prebiotics, and synbiotics on gut microbiota in older adults: a systematic review and meta-analysis of randomized controlled trials
Effects of probiotics, prebiotics, and synbiotics on gut microbiota in older adults: a systematic review and meta-analysis of randomized controlled trials Open
Background There is a lack of evidence on microbial compositions and associated metabolic changes in probiotics, prebiotics, or synbiotics (PPS) in older adults. Objective This meta-analysis aims to evaluate the effects of PPS on gut micro…
View article: DEFA5-producing CD4+ T cells in the intestines of atopic dermatitis patients play an important role in the development of AD-associated intestinal inflammation
DEFA5-producing CD4+ T cells in the intestines of atopic dermatitis patients play an important role in the development of AD-associated intestinal inflammation Open
Rationale Atopic dermatitis (AD) is associated with various gastrointestinal symptoms, yet the underlying mechanisms remain poorly understood. This study aimed to investigate intraepithelial lymphocytes (IELs) in the intestines of AD patie…
View article: High humidity environment increases FBG by impairing the intestinal barrier
High humidity environment increases FBG by impairing the intestinal barrier Open
Introduction Climate and environmental changes pose significant threats to human metabolic health; however, the specific effects of individual environmental factors on metabolic diseases remain poorly understood. This study aimed to invest…
View article: A neural substrate of comorbid depressive symptoms in alcohol use
A neural substrate of comorbid depressive symptoms in alcohol use Open
Alcohol use disorder (AUD) is commonly associated with depression, which may exacerbate the clinical outcome and increase treatment difficulty. The neural substrates underlying such comorbid symptoms are unclear. Here, we identify the regu…
View article: Dynamic Response of Buried Pressurized Pipelines When Subjected to Transverse Impact Loading: Experimental Study
Dynamic Response of Buried Pressurized Pipelines When Subjected to Transverse Impact Loading: Experimental Study Open
This study investigated the dynamic behavior of pressurized pipelines under impact loads in various burial environments. A total of 60 tests were conducted using a drop-weight impact testing apparatus, with high-speed cameras and sensors u…
View article: Dissecting Causal Relationships Between gut microbiota imbalance, inflammatory cytokines, and structural connectivity in the brain: A Mendelian Randomization Study
Dissecting Causal Relationships Between gut microbiota imbalance, inflammatory cytokines, and structural connectivity in the brain: A Mendelian Randomization Study Open
Background: Growing evidence indicates that the imbalances in gut microbiota influence brain structural connectivity, a key component of the microbiota-gut-brain axis. However, a deeper understanding of this complex bidirectional relations…
View article: Progress in Polysaccharide-Based Hydrogels for Preventing Postoperative Adhesions: A Review
Progress in Polysaccharide-Based Hydrogels for Preventing Postoperative Adhesions: A Review Open
Postoperative adhesions are common complications following surgery, often accompanied by pain and inflammation that significantly diminish patients’ quality of life. Moreover, managing postoperative adhesions incurs substantial cost, impos…
View article: PLIN1 suppresses glioma progression through regulating lipid metabolism
PLIN1 suppresses glioma progression through regulating lipid metabolism Open
Glioma is a common and destructive brain tumor, which is highly heterogeneous with poor prognosis. Developing diagnostic and prognostic markers to identify and treat glioma early would significantly improve the therapeutic outcomes. Here, …
View article: Susceptibility Mechanisms and Prediction Model for COVID-19 in China Based on a Suite of Transcriptome Profiling
Susceptibility Mechanisms and Prediction Model for COVID-19 in China Based on a Suite of Transcriptome Profiling Open
View article: Clinical signature and associated immune metabolism of <scp>NLRP1</scp> in pan‐cancer
Clinical signature and associated immune metabolism of <span>NLRP1</span> in pan‐cancer Open
Inflammations have been linked to tumours, suggesting a potential association between NLRP1 and cancer. Nevertheless, a systematic assessment of NLRP1's role across various cancer types currently absent. A comprehensive bioinformatic analy…
View article: Assessment of SWI/SNF chromatin remodeling complex related genes as potential biomarkers and therapeutic targets in pan-cancer
Assessment of SWI/SNF chromatin remodeling complex related genes as potential biomarkers and therapeutic targets in pan-cancer Open
View article: A cingulate-hippocampal circuit mediates early depressive-like behavior in the mouse model of Alzheimer disease
A cingulate-hippocampal circuit mediates early depressive-like behavior in the mouse model of Alzheimer disease Open
View article: Menin Deficiency Induces Autism‐Like Behaviors by Regulating <i>Foxg1</i> Transcription and Participates in <i>Foxg1</i>‐Related Encephalopathy
Menin Deficiency Induces Autism‐Like Behaviors by Regulating <i>Foxg1</i> Transcription and Participates in <i>Foxg1</i>‐Related Encephalopathy Open
FOXG1 syndrome is a developmental encephalopathy caused by FOXG1 (Forkhead box G1) mutations, resulting in high phenotypic variability. However, the upstream transcriptional regulation of Foxg1 expression remains unclear. This report demon…
View article: Reflections on "Voices from the Heart" Workshop
Reflections on "Voices from the Heart" Workshop Open
The work of education innovation is stressful, challenging, and at times isolating. Through the delivery of a workshop we developed, we create an intimate and brave space to explore our own well-being and thriving using the practices of in…
View article: Investigation and Analysis of Service Performance of Cable Arch Bridge Structure Under Accidental Lateral Load
Investigation and Analysis of Service Performance of Cable Arch Bridge Structure Under Accidental Lateral Load Open
This article investigates the response behavior of such structures under unexpected lateral impact loads, and quantitatively studies the impact of vibration caused by impact on driving performance, pedestrian comfort, and other aspects. Ba…
View article: A novel copper metabolism-related signature model for predicting the prognosis, target drugs, and immunotherapy in stomach adenocarcinoma
A novel copper metabolism-related signature model for predicting the prognosis, target drugs, and immunotherapy in stomach adenocarcinoma Open
View article: Hypothalamic Menin regulates systemic aging and cognitive decline
Hypothalamic Menin regulates systemic aging and cognitive decline Open
Aging is a systemic process, which is a risk factor for impaired physiological functions, and finally death. The molecular mechanisms driving aging process and the associated cognitive decline are not fully understood. The hypothalamus act…
View article: A cingulate-hippocampal circuit mediates early depressive symptoms in Alzheimer’s disease
A cingulate-hippocampal circuit mediates early depressive symptoms in Alzheimer’s disease Open
Depressive symptoms are prevalent and precedes cognitive decline in Alzheimer’s disease (AD), which worsen the clinical outcome and severely challenge the life quality of the patients. However, the neural circuitry mediating mood disturban…
View article: An integrated analysis of prognostic mRNA signature in early- and progressive-stage gastric adenocarcinoma
An integrated analysis of prognostic mRNA signature in early- and progressive-stage gastric adenocarcinoma Open
The pathogenesis and vital factors of early and progressive stages of stomach adenocarcinoma (STAD) have not been fully elucidated. In order to discover novel and potential targets to guide effective treatment strategies, a comprehensive b…
View article: A Cingulate-Hippocampal Circuit Mediates Early Depressive Symptoms in the Mouse Model of Alzheimer's Disease
A Cingulate-Hippocampal Circuit Mediates Early Depressive Symptoms in the Mouse Model of Alzheimer's Disease Open
View article: High Humidity Exacerbates Hyperglycemia Through Modulating Gut Microbiome and GABA
High Humidity Exacerbates Hyperglycemia Through Modulating Gut Microbiome and GABA Open
View article: Hydrodynamic cavitation-enhanced photocatalytic activity of P-doped TiO2 for degradation of ciprofloxacin: Synergetic effect and mechanism
Hydrodynamic cavitation-enhanced photocatalytic activity of P-doped TiO2 for degradation of ciprofloxacin: Synergetic effect and mechanism Open
View article: First Thrive, Then Lead: An Emerging Approach to Engineering Leadership Education
First Thrive, Then Lead: An Emerging Approach to Engineering Leadership Education Open
The study of human psychology has demonstrated that satisfying a set of basic psychological needs - autonomy, relatedness, and compentence - is essential for personal well-being and thriving. However, student mental health data across Nort…
View article: High-sensitivity stereo coded aperture gamma camera for three-dimensional localization of radioactive hotspots
High-sensitivity stereo coded aperture gamma camera for three-dimensional localization of radioactive hotspots Open
This work presents a novel stereo coded aperture gamma camera based on four detection modules placed within four quadrants. Each module includes 48 × 48 strips of Bi4Ge3O12 scintillators, 24 × 24 pieces of silicon photomultipliers (SiPMs),…
View article: Correction: Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis
Correction: Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis Open
View article: Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis
Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis Open
View article: Hydrodynamic Cavitation-Enhanced Photocatalytic Activity of P-Doped TiO2 for Degradation of Ciprofloxacin: Synergetic Effect and Mechanism
Hydrodynamic Cavitation-Enhanced Photocatalytic Activity of P-Doped TiO2 for Degradation of Ciprofloxacin: Synergetic Effect and Mechanism Open
View article: Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis
Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis Open
Oxidative stress is the main factor responsible for the induction of diabetic renal fibrosis. Thus, improving the state of oxidative stress can effectively prevent the further deterioration of diabetic nephropathy (DN). Previous research h…