Kui Liu
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View article: The transcription factor FOXA1 upregulates PYCR1-mediated autophagy to suppress antitumor immunity in lung adenocarcinoma
The transcription factor FOXA1 upregulates PYCR1-mediated autophagy to suppress antitumor immunity in lung adenocarcinoma Open
FOXA1 upregulates PYCR1 expression, activates autophagy in LUAD cells, and dampens CD8+ T cell antitumor immune response. Targeting FOXA1/PYCR1 may be a potential approach to improve LUAD immunotherapy.
View article: Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005–2024
Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005–2024 Open
Background Syphilis remains one of the serious public health challenges in China and worldwide. This study aims to assess the potential independent risks associated with age, period, and birth cohort for the reported incidence of syphilis …
View article: Serum syndecan-1 is related to severity and prognosis of COVID-19 patients: a perspective cohort study
Serum syndecan-1 is related to severity and prognosis of COVID-19 patients: a perspective cohort study Open
The serum syndecan-1 concentration is positively correlated with the severity and poor prognosis in COVID-19 patients. Syndecan-1 is a potential biomarker for the diagnosis and prognosis of COVID-19 in the future.
View article: Parameter Identification and Transition Process Online Calibration Method of Pulsed Eddy Current Receiving Coil Based on Underdamped Dynamic Response Characteristics
Parameter Identification and Transition Process Online Calibration Method of Pulsed Eddy Current Receiving Coil Based on Underdamped Dynamic Response Characteristics Open
In order to solve the problem that the system parameters will be offset during the detection process of the pulsed eddy current receiving coil, this paper first analyzes the response signal of the receiving system and the deconvolution pro…
View article: Platelet aggregation rate serves as a significant predictive indicator for thromboembolic events in the context of stent-assisted embolization for unruptured arterial aneurysms
Platelet aggregation rate serves as a significant predictive indicator for thromboembolic events in the context of stent-assisted embolization for unruptured arterial aneurysms Open
Background Perioperative cerebrovascular thromboembolic events are serious complications of stent-assisted embolization (SAE) for unruptured intracranial aneurysms (UIAs). To date, there have been no definitive clinical trial results to ef…
View article: Prevalence, Progression, and Treatment of Asymptomatic Tuberculosis: A Prospective Cohort Study in Lanxi County, Zhejiang Province, China
Prevalence, Progression, and Treatment of Asymptomatic Tuberculosis: A Prospective Cohort Study in Lanxi County, Zhejiang Province, China Open
Background Individuals with asymptomatic tuberculosis (TB) are considered a significant risk to the disease burden and transmission. However, the progression and treatment for asymptomatic TB remain incompletely described. Methods This pro…
View article: Health economic evaluation of newborn hepatitis B immunization prevention strategies in Ningbo: a Markov modeling study
Health economic evaluation of newborn hepatitis B immunization prevention strategies in Ningbo: a Markov modeling study Open
Background Hepatitis B virus (HBV) infection poses a significant public health challenge in China. The Prevention of mother-to-child Transmission (PMTCT) strategy of combining universal hepatitis B vaccination with hepatitis B immunoglobul…
View article: Time series analysis and scaling law characteristics of viral hepatitis from 2004 to 2023 in Zhejiang Province, China
Time series analysis and scaling law characteristics of viral hepatitis from 2004 to 2023 in Zhejiang Province, China Open
Background Hepatitis significantly increases the global disease burden and has become a major public health issue worldwide. China is a high-risk area for viral hepatitis, which is also a serious public health problem. Methods The scaling …
View article: Constructing a Resilience Assessment Index System for Tuberculosis Healthcare Services Under Public Health Emergencies: A Modified Delphi Study
Constructing a Resilience Assessment Index System for Tuberculosis Healthcare Services Under Public Health Emergencies: A Modified Delphi Study Open
This study developed a unified hierarchical resilience assessment index system for TB-HSs in China. Further research is required to validate and improve our results. The study's findings could help develop strategies that benefit public he…
View article: Health system delay and risk factors in pulmonary tuberculosis diagnosis before and during the COVID-19 epidemic: a multi-center survey in China
Health system delay and risk factors in pulmonary tuberculosis diagnosis before and during the COVID-19 epidemic: a multi-center survey in China Open
Background Understanding health system delay (HSD) in pulmonary tuberculosis (PTB) diagnosis aids in tailoring interventions for case detection and curbing transmission. However, recent nationwide studies on HSD in PTB diagnosis have been …
View article: Application of the age-period-cohort model in tuberculosis
Application of the age-period-cohort model in tuberculosis Open
Up to now, tuberculosis (TB) remains a global public health problem, posing a serious threat to human health. Traditional methods for analyzing time-varying trends, such as age and period, tend to ignore the poor impact of birth cohorts, w…
View article: Prevalence and clinical profile of comorbidity among newly diagnosed pulmonary tuberculosis patients: a multi-center observational study in eastern China
Prevalence and clinical profile of comorbidity among newly diagnosed pulmonary tuberculosis patients: a multi-center observational study in eastern China Open
Objective To identify the composition of comorbidities among patients with newly diagnosed pulmonary tuberculosis and assess the impact of comorbidities on the clinical characteristics of patients. Methods This study was conducted in 13 ho…
View article: Method and Experimental Research of Transmission Line Tower Grounding Body Condition Assessment Based on Multi-Parameter Time-Domain Pulsed Eddy Current Characteristic Signal Extraction
Method and Experimental Research of Transmission Line Tower Grounding Body Condition Assessment Based on Multi-Parameter Time-Domain Pulsed Eddy Current Characteristic Signal Extraction Open
Pole tower grounding bodies are part of the normal structure of the power system, providing relief from fault currents and equalizing overvoltage channels. They are important devices; however, in the harsh environment of the soil, they are…
View article: ATS-Kriging: An adaptive two-stage Kriging sequential modeling for performance prediction of aero-engine structure
ATS-Kriging: An adaptive two-stage Kriging sequential modeling for performance prediction of aero-engine structure Open
View article: The asymptomatic tuberculosis proportion among the elderly population: a systematic review and meta-analysis
The asymptomatic tuberculosis proportion among the elderly population: a systematic review and meta-analysis Open
The latest results revealed a significantly high percentage of elderly individuals with asymptomatic tuberculosis. This study highlighted the importance of mass screening to identify active tuberculosis cases in this specific group which c…
View article: Effects of meteorological factors on tuberculosis and potential modifiers in Zhejiang Province, China
Effects of meteorological factors on tuberculosis and potential modifiers in Zhejiang Province, China Open
Although some studies have explored the role of meteorological factors in the development of tuberculosis (TB), the majority have been confined to single regions, leading to inconsistent findings. Consequently, we conducted a multi-city st…
View article: Spatiotemporal distribution and risk factors for patient and diagnostic delays among groups with tuberculous pleurisy: an analysis of 5-year surveillance data in eastern China
Spatiotemporal distribution and risk factors for patient and diagnostic delays among groups with tuberculous pleurisy: an analysis of 5-year surveillance data in eastern China Open
Objective To understand and analyze the factors relating to patient and diagnostic delays among groups with tuberculous pleurisy (TP), and its spatiotemporal distribution in Zhejiang Province. Methods Data of all tuberculous pleurisy patie…
View article: Analyzing spatial delays of tuberculosis from surveillance and awareness surveys in Eastern China
Analyzing spatial delays of tuberculosis from surveillance and awareness surveys in Eastern China Open
View article: Factors associated with tuberculosis care-seeking and diagnostic delays among childhood pulmonary tuberculosis in Zhejiang Province, China: a 10-year retrospective study
Factors associated with tuberculosis care-seeking and diagnostic delays among childhood pulmonary tuberculosis in Zhejiang Province, China: a 10-year retrospective study Open
We conducted a retrospective study to investigate risk factors for tuberculosis care-seeking delay and diagnostic delays among pediatric pulmonary tuberculosis cases in Zhejiang Province from 2013 to 2022. Among 1274 cases, 49.61% experien…
View article: Comparison of blended learning and traditional lecture method on learning outcomes in the evidence-based medicine course: a comparative study
Comparison of blended learning and traditional lecture method on learning outcomes in the evidence-based medicine course: a comparative study Open
View article: Chinese herbal medicine Shufeng Jiedu capsule for mild to moderate COVID-19: a multicenter, randomized, double-blind, placebo-controlled phase II trial
Chinese herbal medicine Shufeng Jiedu capsule for mild to moderate COVID-19: a multicenter, randomized, double-blind, placebo-controlled phase II trial Open
Background: The COVID-19 pandemic has had a profound global impact, although the majority of recently infected cases have presented with mild to moderate symptoms. Previous clinical studies have demonstrated that Shufeng Jiedu (SFJD) capsu…
View article: Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke
Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke Open
Neuroinflammation plays a significant role in ischemic injury, which can be promoted by oxidized mitochondrial DNA (Ox-mtDNA). Cytidine/uridine monophosphate kinase 2 (CMPK2) regulates mtDNA replication, but its role in neuroinflammation a…
View article: Analysis on time delay of tuberculosis among adolescents and young adults in Eastern China
Analysis on time delay of tuberculosis among adolescents and young adults in Eastern China Open
Background Tuberculosis (TB) is recognized as a significant global public health concern. Still, there remains a dearth of comprehensive evaluation regarding the specific indicators and their influencing factors of delay for adolescents an…
View article: Digital tool assessment for the community management of patients with pulmonary tuberculosis in Yiwu city, China: evidence from real world data in 2020
Digital tool assessment for the community management of patients with pulmonary tuberculosis in Yiwu city, China: evidence from real world data in 2020 Open
Background High-quality medication compliance is critical for the cure of pulmonary tuberculosis (PTB); however, the implementation of directly observed treatment (DOT) under direct interview still faces huge difficulties. Assessment of th…
View article: Trend of the Tuberculous Pleurisy Notification Rate in Eastern China During 2017-2021: Spatiotemporal Analysis
Trend of the Tuberculous Pleurisy Notification Rate in Eastern China During 2017-2021: Spatiotemporal Analysis Open
Background Tuberculous pleurisy (TP) presents a serious allergic reaction in the pleura caused by Mycobacterium tuberculosis; however, few studies have described its spatial epidemiological characteristics in eastern China. Objective This …
View article: Direct Medical Expenses and Influencing Factors of MDR/RR-TB in Eastern China: Based on Data from Multi-Hospital Information Systems
Direct Medical Expenses and Influencing Factors of MDR/RR-TB in Eastern China: Based on Data from Multi-Hospital Information Systems Open
DME of patients with MDR/RR-TB was still significant, and domestic migrants, hospitalization, long treatment duration, and high health insurance rates increased the financial burden on MDR/RR-TB patients. Reasonable intervention programs s…
View article: Delay analysis of pulmonary tuberculosis in the eastern coastal county of China from 2010 to 2021: evidence from two surveillance systems
Delay analysis of pulmonary tuberculosis in the eastern coastal county of China from 2010 to 2021: evidence from two surveillance systems Open
Background Tuberculosis (TB) remains a major public health challenge. However, indicators of delays in assessing effective TB prevention and control and its influencing factors have not been investigated in the eastern coastal county of Ch…
View article: Influencing Factors of Treatment Outcomes Among Patients with Pulmonary Tuberculosis: A Structural Equation Model Approach
Influencing Factors of Treatment Outcomes Among Patients with Pulmonary Tuberculosis: A Structural Equation Model Approach Open
Interventions aimed at improving the treatment outcomes of patients with PTB should mainly focus on financial support and improvements in psychological status in addition to a greater understanding and knowledge of PTB. Furthermore, patien…
View article: Mass Tuberculosis Screening Among the Elderly: A Population-Based Study in a Well-Confined, Rural County in Eastern China
Mass Tuberculosis Screening Among the Elderly: A Population-Based Study in a Well-Confined, Rural County in Eastern China Open
Background Mass tuberculosis (TB) screening has been recommended in certain high-risk populations. However, population-based screening interventions have rarely been implemented. Whether mass screening improves health equity is unknown. Me…
View article: Myopia in elementary school students in Eastern China during the COVID-19 pandemic
Myopia in elementary school students in Eastern China during the COVID-19 pandemic Open
Background Myopia is an increasingly serious public concern, particularly among primary school students. The prevalence of myopia and its influencing factors in primary school pupils in Eastern China during the COVID-19 pandemic had not be…