Kaicheng Xu
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View article: Selective promotion of sensory innervation–mediated immunoregulation for tissue repair
Selective promotion of sensory innervation–mediated immunoregulation for tissue repair Open
Sensory innervation triggers the regenerative response after injury. However, dysfunction and impairment of sensory nerves, accompanied by excessive inflammation impede tissue regeneration. Consequently, specific induction of sensory inner…
View article: Extracellular vesicle-mediated gene therapy targets BRAFV600E-mutant colorectal cancer by inhibiting the MEK1/2-ERK1/2 pathway
Extracellular vesicle-mediated gene therapy targets BRAFV600E-mutant colorectal cancer by inhibiting the MEK1/2-ERK1/2 pathway Open
The therapeutic EVs we constructed are effective and specific for the BRAFV600E-mutant CRC. This study provides a novel strategy for the treatment of CRC patients with BRAFV600E mutation.
View article: High transmission of circularly polarized light and circular dichroism with all-dielectric metamaterial
High transmission of circularly polarized light and circular dichroism with all-dielectric metamaterial Open
The optical chirality of metamaterials gives birth to distinct responses of left circularly polarized (LCP) and right circularly polarized (RCP) light, leading to asymmetric transmission and circular dichroism (CD) of circularly polarized …
View article: HSP47 Destabilizes CD155 Through TRAF2 in Synergistic Anti-TIGIT Treatment of Osteosarcoma
HSP47 Destabilizes CD155 Through TRAF2 in Synergistic Anti-TIGIT Treatment of Osteosarcoma Open
Heat shock protein 47 (HSP47) plays an essential role in correcting protein folding, and abnormal protein folding is closely related to tumorigenesis. However, the relationship between HSP47 and cancer immune response is poorly studied. He…
View article: Extracellular Vesicles for Therapeutic Applications
Extracellular Vesicles for Therapeutic Applications Open
Extracellular vesicles (EVs) are cell-derived nanoparticles containing endogenous bioactivators or loading exogenously therapeutics, which serve as “messengers” in intercellular and inter-organismal communication, in both normal and pathol…
View article: VGLL4 Protects against Oxidized-LDL-Induced Endothelial Cell Dysfunction and Inflammation by Activating Hippo-YAP/TEAD1 Signaling Pathway
VGLL4 Protects against Oxidized-LDL-Induced Endothelial Cell Dysfunction and Inflammation by Activating Hippo-YAP/TEAD1 Signaling Pathway Open
Vestigial-like 4 (VGLL4) has been found to have multiple functions in tumor development; however, its role in cardiovascular disease is unknown. The aim of this study was to investigate the effect of VGLL4 on the dysfunction and inflammato…
View article: Effect of mixed liquor suspended solids (MLSS) on simultaneous nitrification and denitrification in a sequencing batch reactor
Effect of mixed liquor suspended solids (MLSS) on simultaneous nitrification and denitrification in a sequencing batch reactor Open
This study investigated the effect of MLSS on simultaneous nitrification and denitrification in a sequencing batch reactor treating domestic wastewater. The average removal efficiencies of COD and TN increased from 93 and 68.21% to 97 and …
View article: Post-Transcriptional Control of Angiotensin II Type 1 Receptor Regulates Osteosarcoma Cell Death
Post-Transcriptional Control of Angiotensin II Type 1 Receptor Regulates Osteosarcoma Cell Death Open
Background/Aims: MicroRNAs (miRNAs) play an essential role in the tumorigenesis of osteosarcoma (OS). However, the effects of miR-1248 on chemo-resistant potential of OS have not been studied. Here, we addressed this question. Methods: The…
View article: Upregulation of microRNA-876 Induces Endothelial Cell Apoptosis by Suppressing Bcl-Xl in Development of Atherosclerosis
Upregulation of microRNA-876 Induces Endothelial Cell Apoptosis by Suppressing Bcl-Xl in Development of Atherosclerosis Open
Background/Aims: The injury and apoptotic cell death of endothelial cells hallmark the development of atherosclerosis (AS), characterized by dysregulation of lipid homeostasis, immune responses, and formation of coronary plaques. However, …