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View article: Multi-trait genome-wide analysis identified risk loci and candidate drugs for heart failure
Multi-trait genome-wide analysis identified risk loci and candidate drugs for heart failure Open
Heart failure (HF) is a common cardiovascular syndrome that poses significant morbidity and mortality risks. While genome-wide association studies reporting on HF abound, its genetic etiology remains poorly elucidated, primarily due to its…
View article: AU-Blendshape for Fine-grained Stylized 3D Facial Expression Manipulation
AU-Blendshape for Fine-grained Stylized 3D Facial Expression Manipulation Open
While 3D facial animation has made impressive progress, challenges still exist in realizing fine-grained stylized 3D facial expression manipulation due to the lack of appropriate datasets. In this paper, we introduce the AUBlendSet, a 3D f…
View article: Multi-trait genome-wide analysis identified novel risk loci and candidate drugs for heart failure
Multi-trait genome-wide analysis identified novel risk loci and candidate drugs for heart failure Open
Heart failure (HF) is a common cardiovascular syndrome that poses significant morbidity and mortality risks. While genome-wide association studies reporting on HF abound, its genetic etiology remains poorly elucidated, primarily due to its…
View article: Characterizing brain imaging features associated with ADAS-Cog13 sub-scores with 3D convolutional neural networks
Characterizing brain imaging features associated with ADAS-Cog13 sub-scores with 3D convolutional neural networks Open
To date, few advanced machine learning models have been developed for investigating the associations between features from brain imaging and individual Alzheimer’s disease (AD) related cognitive functional changes. Additionally, how these …
View article: Improving brain age estimates with deep learning leads to identification of novel genetic factors associated with brain aging
Improving brain age estimates with deep learning leads to identification of novel genetic factors associated with brain aging Open
Brain aging trajectories among those of the same chronological age can vary significantly. Statistical models have been created for estimating the apparent age of the brain, or predicted brain age, with imaging data. Recently, convolutiona…
View article: Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants
Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants Open
Brain age is a metric that quantifies the degree of aging of a brain based on whole-brain anatomical characteristics. While associations between individual human brain regions and environmental or genetic factors have been investigated, ho…
View article: Identification of Dysregulated Genes for Late-Onset Alzheimer's Disease Using Gene Expression Data in Brain.
Identification of Dysregulated Genes for Late-Onset Alzheimer's Disease Using Gene Expression Data in Brain. Open
The differentially expressed genes were associated with axon and synaptic transmissions which affect the neuronal connectivity in cognitive systems involved in AD pathophysiology. These genes may open ways to explore new effective treatmen…
View article: Supplementary_Table_5_SNP_p_value
Supplementary_Table_5_SNP_p_value Open
Supplementary_Table_5_SNP_p_value
View article: SNP_RBA_association_P
SNP_RBA_association_P Open
Relative brain age association p-value for each SNP.
View article: SNP_RBA_association_P
SNP_RBA_association_P Open
Relative brain age association p-value for each SNP.
View article: Association_results
Association_results Open
Supplementary Table 3 P-values from the tests for association between each genetic variants and relative brain age. Supplementary Table 4 P-values from the tests for association between each gene and relative brain age. Supplementary Table…
View article: Association_results
Association_results Open
Supplementary Table 3 P-values from the tests for association between each genetic variants and relative brain age. Supplementary Table 4 P-values from the tests for association between each gene and relative brain age. Supplementary Table…
View article: Association of brain age with smoking, alcohol consumption, and genetic variants
Association of brain age with smoking, alcohol consumption, and genetic variants Open
The association of the degree of aging based on the whole-brain anatomical characteristics, or brain age, with smoking, alcohol consumption, and individual genetic variants is unclear. Here, we investigated these associations through analy…
View article: Age-Related Differences in Brain Morphology and the Modifiers in Middle-Aged and Older Adults
Age-Related Differences in Brain Morphology and the Modifiers in Middle-Aged and Older Adults Open
Brain structural morphology differs with age. This study examined age-differences in surface-based morphometric measures of cortical thickness, volume, and surface area in a well-defined sample of 8137 generally healthy UK Biobank particip…