Kaifan Liu
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View article: Challenges and strategies in clinical applications of CAR-T therapy for autoimmune diseases
Challenges and strategies in clinical applications of CAR-T therapy for autoimmune diseases Open
Chimeric antigen receptor (CAR) T-cell therapy has demonstrated substantial efficacy against various hematological malignancies. The remarkable success of CAR-T cell therapy in targeting B-cell malignancies has generated significant intere…
View article: Causal Effects of AL Amyloidosis on Autoimmune Diseases and the Role of Inflammatory Cytokines: Insights from Mendelian Randomization
Causal Effects of AL Amyloidosis on Autoimmune Diseases and the Role of Inflammatory Cytokines: Insights from Mendelian Randomization Open
Background This study aims to investigate the causal effect of amyloid light-chain (AL) amyloidosis on autoimmune diseases (ADs), with a focus on identifying inflammatory cytokines as potential mediators from a genetic perspective. Methods…
View article: Identifying and assessing a prognostic model based on disulfidptosis-related genes: implications for immune microenvironment and tumor biology in lung adenocarcinoma
Identifying and assessing a prognostic model based on disulfidptosis-related genes: implications for immune microenvironment and tumor biology in lung adenocarcinoma Open
Introduction Lung cancer, with the highest global mortality rate among cancers, presents a grim prognosis, often diagnosed at an advanced stage in nearly 70% of cases. Recent research has unveiled a novel mechanism of cell death termed dis…
View article: Constructing and Evaluating a Mitophagy-Related Gene Prognostic Model: Implications for Immune Landscape and Tumor Biology in Lung Adenocarcinoma
Constructing and Evaluating a Mitophagy-Related Gene Prognostic Model: Implications for Immune Landscape and Tumor Biology in Lung Adenocarcinoma Open
Mitophagy, a conserved cellular mechanism, is crucial for cellular homeostasis through the selective clearance of impaired mitochondria. Its emerging role in cancer development has sparked interest, particularly in lung adenocarcinoma (LUA…
View article: m 6 A demethylase ALKBH5 regulates TP53 to promote malignant transformation of lung cells induced by radon exposure via BTG2-mediated mitochondrial pathway
m 6 A demethylase ALKBH5 regulates TP53 to promote malignant transformation of lung cells induced by radon exposure via BTG2-mediated mitochondrial pathway Open
Lung cancer is a multi-etiological disease and radon is known as the second most common risk factor for the disease. The tumor suppressor gene TP53 is commonly mutated in human lung cancer, thus contributing to the alteration of mitochondr…