Kai‐Feng Pan
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View article: Proteomic profiling and scRNA sequencing identify signatures associated with Helicobacter pylori infection and risk of developing gastric cancer
Proteomic profiling and scRNA sequencing identify signatures associated with Helicobacter pylori infection and risk of developing gastric cancer Open
Objective: The key molecular events signifying the Helicobacter pylori-induced gastric carcinogenesis process are largely unknown. Methods: Bulk tissue-proteomics profiling were leveraged across multi-stage gastric lesions from Linqu (n &#…
View article: Measuring short-range correlations and quasi-elastic cross sections in A(e,e') at x>1 and modest Q$^2$
Measuring short-range correlations and quasi-elastic cross sections in A(e,e') at x>1 and modest Q$^2$ Open
We present results from the Jefferson Lab E08-014 experiment, investigating short-range correlations (SRC) through measurements of absolute inclusive quasi-elastic cross sections and their ratios. This study utilized 3.356 GeV electrons sc…
View article: Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study
Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study Open
Objective: Based on multistage metabolomic profiling and Mendelian randomization analyses, the current study identified plasma metabolites that predicted the risk of developing gastric cancer (GC) and determined whether key metabolite leve…
View article: Population structure of <i>Helicobacter pylori</i> and antibiotic resistance-associated variants in a high-risk area of gastric cancer
Population structure of <i>Helicobacter pylori</i> and antibiotic resistance-associated variants in a high-risk area of gastric cancer Open
The increasing antibiotic resistance of Helicobacter pylori has had a serious impact on gastric cancer prevention. Our study aimed to profile the genomic characteristics and explore variants associated with resistance in H. pylori strains …
View article: Integrative metabolomics and microbiomics analysis reveals distinctive microbiota‐metabolites interactions in gastric carcinogenesis
Integrative metabolomics and microbiomics analysis reveals distinctive microbiota‐metabolites interactions in gastric carcinogenesis Open
Gastric microbiota and metabolites may interact and play collaborative roles in the carcinogenesis process. This study aims to investigate differential metabolites and microbes, as well as the possible roles of microbe‐metabolite interacti…
View article: Gastric cancer detection based on cell‐free DNA in blood: A systematic review and meta‐analysis
Gastric cancer detection based on cell‐free DNA in blood: A systematic review and meta‐analysis Open
Objective Screening and early diagnosis of gastric cancer (GC) are crucial for improved prognosis. However, gastroscopic screening is not feasible in large populations due to its high cost and invasive nature. The detection of circulating …
View article: Forty years of practice against gastric cancer in Linqu County, a high‐risk area of gastric cancer in China
Forty years of practice against gastric cancer in Linqu County, a high‐risk area of gastric cancer in China Open
Gastric cancer (GC) is a global public health burden, with nearly one million new cases diagnosed each year worldwide. To investigate the risk factors and the prevention strategies for GC, in the past 40 years, a series of epidemiological …
View article: Gastric microbiota and its role in gastric carcinogenesis
Gastric microbiota and its role in gastric carcinogenesis Open
Gastric cancer (GC) is one of the most common malignancies globally, the occurrence of which undergoes a multistage chronic evolutionary process. It is a great public health issue to deeply understand the mechanisms of GC development and f…
View article: Metabolite Alterations and Interactions with Microbiota in Helicobacter pylori-Associated Gastric Lesions
Metabolite Alterations and Interactions with Microbiota in Helicobacter pylori-Associated Gastric Lesions Open
In this study, a panel was established including differential metabolites, genera, and their interactions, which may help to discriminate high-risk subjects for progression from mild lesions to advanced precancerous lesions in short-term a…
View article: Gastric cancer‐associated long non‐coding RNA profiling and noninvasive biomarker screening based on a high‐risk population cohort
Gastric cancer‐associated long non‐coding RNA profiling and noninvasive biomarker screening based on a high‐risk population cohort Open
Background Effective noninvasive biomarkers of gastric cancer (GC) are critical for early detection and improvement of prognosis. We performed genome‐wide long non‐coding RNA (lncRNA) microarray analysis to identify and validate novel GC b…
View article: Supplementary Table 1 from Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population
Supplementary Table 1 from Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population Open
The association of evolutions of Ind DYS/DYS subjects with COX-2 expression changes.
View article: Supplementary Table 1 from Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population
Supplementary Table 1 from Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population Open
The association of evolutions of Ind DYS/DYS subjects with COX-2 expression changes.
View article: Table S1, Table S2, Table S3, Table S4, Details for immunohistochemical staining from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population
Table S1, Table S2, Table S3, Table S4, Details for immunohistochemical staining from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population Open
Table S1. Differentially methylated CpGs of non-clustered PCDHs by H. pylori eradication in the whole-genome methylation profiling. Table S2. The association between major characteristics and methylation of four PCDH genes. Table S3. Assoc…
View article: Data from Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population
Data from Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population Open
To explore the epigenetic mechanisms underlying the effects of anti-Helicobacter pylori (H. pylori) alone and combined with COX-2 inhibitor (celecoxib), we dynamically evaluated the associations between COX-2 methylation alterations and ga…
View article: Data from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population
Data from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population Open
Nonclustered protocadherins (PCDH) family is a group of cell–cell adhesion molecules. We have found differentially methylated genes in the nonclustered PCDHs family associated with Helicobacter pylori (H. pylori) infection in prior genome-…
View article: Table S1, Table S2, Table S3, Table S4, Details for immunohistochemical staining from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population
Table S1, Table S2, Table S3, Table S4, Details for immunohistochemical staining from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population Open
Table S1. Differentially methylated CpGs of non-clustered PCDHs by H. pylori eradication in the whole-genome methylation profiling. Table S2. The association between major characteristics and methylation of four PCDH genes. Table S3. Assoc…
View article: Supplemental Figure S1 from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population
Supplemental Figure S1 from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population Open
Figure S1. Representative pictures of immunohistochemical staining for PCDH10 and PCDH17 (20X) PCDH10 and PCDH17 were expressed in the membrane and cytoplasm of epithelial and some stromal cell. (a, b) Representative pictures of immunohist…
View article: Data from Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population
Data from Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population Open
To explore the epigenetic mechanisms underlying the effects of anti-Helicobacter pylori (H. pylori) alone and combined with COX-2 inhibitor (celecoxib), we dynamically evaluated the associations between COX-2 methylation alterations and ga…
View article: Data from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population
Data from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population Open
Nonclustered protocadherins (PCDH) family is a group of cell–cell adhesion molecules. We have found differentially methylated genes in the nonclustered PCDHs family associated with Helicobacter pylori (H. pylori) infection in prior genome-…
View article: Supplemental Figure S1 from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population
Supplemental Figure S1 from Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population Open
Figure S1. Representative pictures of immunohistochemical staining for PCDH10 and PCDH17 (20X) PCDH10 and PCDH17 were expressed in the membrane and cytoplasm of epithelial and some stromal cell. (a, b) Representative pictures of immunohist…
View article: Data from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population
Data from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population Open
Background: Manganese superoxide dismutase is the primary antioxidant enzyme in the mitochondria and is involved in carcinogenesis. To investigate the association between MnSOD Val16Ala polymorphism and risk of advanced gastric lesions, an…
View article: Supplementary Table 3 from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population
Supplementary Table 3 from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population Open
Supplementary Table 3 from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population
View article: Supplementary Table 1 from Genetic Variants of Toll-Like Receptor 2 and 5, <i>Helicobacter Pylori</i> Infection, and Risk of Gastric Cancer and Its Precursors in a Chinese Population
Supplementary Table 1 from Genetic Variants of Toll-Like Receptor 2 and 5, <i>Helicobacter Pylori</i> Infection, and Risk of Gastric Cancer and Its Precursors in a Chinese Population Open
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View article: Supplementary Table 1 from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population
Supplementary Table 1 from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population Open
Supplementary Table 1 from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population
View article: Data from Genetic Variants of Toll-Like Receptor 2 and 5, <i>Helicobacter Pylori</i> Infection, and Risk of Gastric Cancer and Its Precursors in a Chinese Population
Data from Genetic Variants of Toll-Like Receptor 2 and 5, <i>Helicobacter Pylori</i> Infection, and Risk of Gastric Cancer and Its Precursors in a Chinese Population Open
Background: Genetic polymorphisms of Toll-like receptors (TLR) may influence the outcome of Helicobacter pylori infection and play important roles in gastric carcinogenesis. To screen the genetic variants of TLR2 and TLR5, and evaluate the…
View article: Supplementary Table 2 from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population
Supplementary Table 2 from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population Open
Supplementary Table 2 from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population
View article: Data from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population
Data from Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population Open
Background: Manganese superoxide dismutase is the primary antioxidant enzyme in the mitochondria and is involved in carcinogenesis. To investigate the association between MnSOD Val16Ala polymorphism and risk of advanced gastric lesions, an…