Explanipedia

Targeted screening and single-cell analysis of genetic variants in melanoma using Mendelian randomization Open

Shi Li, Kaijiong Zhang, Guiji Zhang, Min Shi, Xing Yin , et al. · 2025

PlateletBase: A Comprehensive Knowledgebase for Platelet Research and Disease Insights Open

Huaichao Luo, Changchun Wu, Sisi Yu, Hanxiao Ren, Xing Yin , et al. · 2025

Platelets are vital in many pathophysiological processes, yet there is a lack of a comprehensive resource dedicated specifically to platelet research. To fill this gap, we have developed PlateletBase, a knowledge base aimed at enhancing th…

PlateletBase: A Comprehensive Knowledgebase for Platelet Research and Disease Insights Open

Huaichao Luo, Changchun Wu, Sisi Yu, Hanxiao Ren, Xing Yin , et al. · 2024

Platelets are vital in many pathophysiological processes, yet there is a lack of a comprehensive resource dedicated specifically to platelet research. To fill this gap, we have developed PlateletBase, a knowledge base aimed at enhancing th…

Prognostic value of creatine kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection Open

Lubei Rao, Pingyao Xu, Guiji Zhang, Ruiling Zu, Yajun Luo , et al. · 2024

Prognostic value of Creatine Kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection Open

Lubei Rao, Ruiling Zu, Guiji Zhang, Kaijiong Zhang, Shuya He , et al. · 2023

Objectives: This study aimed to evaluate the prognostic significance of postoperative Creatine Kinase (CK)-MB to total-CK ratio (CK-MB/CK) in colorectal cancer (CRC) patients after radical resection. Methods: This was a single-center retro…

Platelet-Based Nanoparticles with Stimuli-Responsive for Anti-Tumor Therapy Open

Linlan Yang, Kaijiong Zhang, Zheng Dongming, Yuxin Bai, Daifan Yue , et al. · 2023

In addition to hemostasis and coagulation, years of studies have proved that platelets are involved in the whole process of tumor progression, including tumor invasion, intravasation, extravasation, and so on. It means that this property o…

A prognostic nomogram that includes <span>MPV</span> in esophageal squamous cell carcinoma Open

Qiao He, Zhenglian Luo, Haiming Zou, Bo Ye, Lichun Wu , et al. · 2023

Background Mean platelet volume (MPV), as a marker of platelet activity, has been shown to be an efficient prognostic biomarker in several types of cancer. Using MPV, this study aimed to create and validate a prognostic nomogram to the ove…

Machine learning‑based prediction of survival prognosis in esophageal squamous cell carcinoma Open

Kaijiong Zhang, Bo Ye, Lichun Wu, Sujiao Ni, Li Yang , et al. · 2023

The current prognostic tools for esophageal squamous cell carcinoma (ESCC) lack the necessary accuracy to facilitate individualized patient management strategies. To address this issue, this study was conducted to develop a machine learnin…

The Progress of Platelets in Breast Cancer Open

Luchang Wang, Kaijiong Zhang, Jia Feng, Dongsheng Wang, Jinbo Liu · 2023

Breast cancer is the most common female cancer and the sixth leading cause of death, seriously affecting the quality of life of women. Platelets, one of the fragments derived from megakaryocytes, are being increasingly investigated by tumo…

Prognostic impact of Creatine Kinase (CK)-MB to total-CK ratio following curative resection of stage I-III colorectal cancer Open

Lubei Rao, Kaijiong Zhang, Yajun Luo, Guiji Zhang, Ying Yang , et al. · 2023

Objectives: The purpose of this study was to evaluate the prognostic significance of Creatine Kinase (CK)-MB to total-CK ratio (CK-MB/CK) in patients with stage I-III colorectal cancer (CRC) after radical resection. Methods: This study was…

Identification and panoramic analysis of drug response-related genes in triple negative breast cancer using as an example NVP-BEZ235 Open

Jia Feng, Luchang Wang, Kaijiong Zhang, Sujiao Ni, Baolin Li , et al. · 2023

Taking NVP-BEZ235 (BEZ235) as an example to screen drug response-related genes (DRRGs) and explore their potential value in triple-negative breast cancer (TNBC). Through high-throughput technique, multidimensional transcriptome expression …

Prognostic value of nutritional and inflammatory indicators in females with esophageal squamous cell cancer: A propensity score matching study Open

Yuping Li, Huaichao Luo, Bo Ye, Kaijiong Zhang, Chang Liu , et al. · 2022

Background: Esophageal squamous cell cancer (ESCC) is a disease with a male predominance. Accordingly, the applicability of prognostic indicators values previously set for the general population with ESCC has not been reported for determin…

Clinlabomics: leveraging clinical laboratory data by data mining strategies Open

Xiaoxia Wen, Ping Leng, Jiasi Wang, Guishu Yang, Ruiling Zu , et al. · 2022

A novel prognostic model for malignant patients with Gram-negative bacteremia based on real-world research Open

Sujiao Ni, Pingyao Xu, Kaijiong Zhang, Haiming Zou, Huaichao Luo , et al. · 2022

Fresh frozen plasma transfusion is a potential predictor of mortality in patients undergoing extracorporeal membrane oxygenation Open

Zhenglian Luo, Qing Li, Shilan Xu, Xinxin Yang, Zhuoyue Peng , et al. · 2022

Background The patients of extracorporeal membrane oxygenation (ECMO) supported were usually developed bleeding complications and required substantial transfusions, but the risks and predictors of transfusion requirements during ECMO suppo…

CircSEC24A promotes tumor progression through sequestering miR-455-3p in hepatocellular carcinoma Open

Yulin Liao, Dongming Yang, Huaichao Luo, Guishu Yang, Xiaoxia Wen , et al. · 2021

Hepatocellular carcinoma (HCC) ranks third in the cause of death due to cancer. Circular RNA circSEC24 Homolog A (circSEC24A) has been uncovered to be upregulated in liver cancer. However, the function of circSEC24A in HCC is indistinct. W…

Normal reference intervals of prognostic nutritional index in healthy adults: A large multi-center observational study from Western China Open

Guishu Yang, Dongsheng Wang, Ruiling Zu, Linbo He, Guangjie Zhang , et al. · 2021

Background It has been widely reported that the prognostic nutritional index (PNI) played a pivotal role in nutritional assessment of surgical patients and tumor prognosis. In order to improve the accuracy of evaluation in western China, w…

Prognostic Value of Nutritional and Inflammatory Indicators in Female With Esophageal Squamous Cell Cancer: A Retrospective Cohort Study Open

Yuping Li, Huaichao Luo, Bo Ye, Kaijiong Zhang, Chang Liu , et al. · 2021

Path planning algorithm of the intelligent vehicle considering the passenger feelings Open

Kaijiong Zhang, Xi Zhang, Weishun Deng, Fan Yu, Shiliang Shang , et al. · 2020

As the autonomous driving vehicle becomes popular, the driver will be completely replaced by autonomous system, but passengers in the vehicle will always exist. Autonomous vehicle has the essential property of transporting people, so the p…

The association between long noncoding RNA H19 and pathological features in cancers: A meta-analysis Open

Meng Cui, Qing Luo, Yi Zhang, Kaijiong Zhang, Jinbo Liu · 2017

Purpose: Long noncoding RNA (lncRNA) H19 has been reported to be up-regulated and down-regulated in numerous tumors, but the relevance of clinical pathological features is not established. So, meta-analysis was conducted to investigate the…

Detection and analysis of circulating large intergenic non‐coding RNA regulator of reprogramming in plasma for breast cancer Open

Kaijiong Zhang, Zhenglian Luo, Yi Zhang, Yuzhi Wang, Meng Cui , et al. · 2017

Background Previous studies have indicated that large intergenic non‐coding RNA regulator of reprogramming (lincRNA‐ROR) plays an important role in regulating tumor carcinogenesis and metastasis; however, whether circulating lincRNA‐ROR co…

Long non-coding RNAs as novel biomarkers for breast cancer invasion and metastasis Open

Kaijiong Zhang, Zhenglian Luo, Yi Zhang, Xiaoyu Song, Li Zhang , et al. · 2017

Breast cancer (BC) is now the most common malignancy worldwide, with high prevalence and lethality among women. Invasion and metastasis are the major reasons for breast cancer-associated mortality. However, the underlying mechanism of inva…

Circulating long non‐coding <span>HOX</span> transcript antisense intergenic ribonucleic acid in plasma as a potential biomarker for diagnosis of breast cancer Open

Yi Zhang, Kaijiong Zhang, Zhenglian Luo, Lian Liu, Lichun Wu , et al. · 2016

Background It is well known that HOX transcript antisense intergenic ribonucleic acid ( HOTAIR ) plays an important role in breast cancer ( BC ). However, whether circulating HOTAIR in plasma could be used for BC diagnosis and dynamic moni…

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