Kaijun Su
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View article: Enlightening epigenetics: optochemical tools illuminate the path
Enlightening epigenetics: optochemical tools illuminate the path Open
Optochemical tools have become potent instruments for understanding biological processes at the molecular level, and the past decade has witnessed their use in epigenetics and epitranscriptomics (also known as RNA epigenetics) for decipher…
View article: Preferred Conformation-Guided Discovery of Potent and Orally Active HIF Prolyl Hydroxylase 2 Inhibitors for the Treatment of Anemia
Preferred Conformation-Guided Discovery of Potent and Orally Active HIF Prolyl Hydroxylase 2 Inhibitors for the Treatment of Anemia Open
In this work, we discovered a novel series of prolyl hydroxylase 2 (PHD2) inhibitors with improved metabolic properties based on a preferred conformation-guided drug design strategy. Piperidinyl-containing linkers with preferred metabolic …
View article: Atmospheric radioactive nuclide deposition on the coast of the Maowei Sea, northern Beibu Gulf, China
Atmospheric radioactive nuclide deposition on the coast of the Maowei Sea, northern Beibu Gulf, China Open
The natural radioisotopes 7 Be, 210 Pb, and 210 Po, with different half-lives, are all particle-reactive and serve as natural tracers to study sources and transportation of sediments, sedimentation rates, and sediment chronology. Atmospher…
View article: In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery
In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery Open
Target‐directed dynamic combinatorial chemistry has emerged as a useful tool for hit identification, but has not been widely used, in part due to challenges associated with analyses involving complex mixtures. We describe an operationally …
View article: In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery
In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery Open
Target‐directed dynamic combinatorial chemistry has emerged as a useful tool for hit identification, but has not been widely used, in part due to challenges associated with analyses involving complex mixtures. We describe an operationally …
View article: Variable Weight Matter–Element Extension Model for the Stability Classification of Slope Rock Mass
Variable Weight Matter–Element Extension Model for the Stability Classification of Slope Rock Mass Open
The slope stability in an open-pit mine is closely related to the production safety and economic benefit of the mine. As a result of the increase in the number and scale of mine slopes, slope instability is frequently encountered in mines.…
View article: Discovery of a Potent and Orally Bioavailable Hypoxia-Inducible Factor 2α (HIF-2α) Agonist and Its Synergistic Therapy with Prolyl Hydroxylase Inhibitors for the Treatment of Renal Anemia
Discovery of a Potent and Orally Bioavailable Hypoxia-Inducible Factor 2α (HIF-2α) Agonist and Its Synergistic Therapy with Prolyl Hydroxylase Inhibitors for the Treatment of Renal Anemia Open
Activation of hypoxia-inducible factor 2 (HIF-2) has emerged as a potent renal anemia treatment strategy. Here, the benzisothiazole derivative 26 was discovered as a novel HIF-2α agonist, which first demonstrated nanomolar activity (EC50 =…
View article: A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation Open
A small-molecule FP probe useful for monitoring binding to PHD2 and identifying potential PHD2 inhibitors.
View article: Physical dosimetry reconstructions of significant radiation exposure at an industrial accelerator facility in Tianjin (China)
Physical dosimetry reconstructions of significant radiation exposure at an industrial accelerator facility in Tianjin (China) Open
The goal of this thesis is to estimate the physical radiation doses for two victims who were accidently exposed to an industrial electron beam at an industrial accelerator facility on 7 July 7 2016 in Tianjin, China. On the basis of the ra…
View article: Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light
Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light Open
HIF prolyl hydroxylase 2 (PHD2) inhibitors represent a novel approach for treating HIF-related diseases. This study reports the first application of photoremovable protecting group to the photoactivatable inhibitor (7) of PHD2. It allows t…