Explanipedia

Targeting the LPS-STING axis: neomycin restores STING-mediated anti-tumor immune suppression and inhibits tumor growth Open

Hong Fan, Dongjie Fu, Mingfu Tian, Kailang Wu, Chengliang Zhu · 2025

Introduction The interplay between microbial metabolites and host immunity within the tumor microenvironment (TME) critically modulates anti-tumor immune responses. The role of Gram-negative bacteria and their cell wall component lipopolys…

Senescent cells promote viral infection-associated inflammation and tissue damage through a robust NF-κB pathway Open

Mingfu Tian, June Ma, Zhiqiang Li, Chenglin Ye, Xianghua Cui , et al. · 2025

Respiratory virus infections have been presenting significant global public health challenges. The virulence of SARS-CoV-2 and seasonal influenza largely relies on triggering abnormal host immune responses, particularly the production of a…

Bridging inflammation and proliferation: scRNA-seq analysis of chemotactic and growth factor signaling in mouse skin wound repair Open

Lingzhang Meng, Hongmian Li, Jian Song, Wenxian Lin, Xiuli Mao , et al. · 2025

Introduction The transition from inflammation to proliferation is a critical but poorly understood phase in wound healing. To elucidate the cellular and molecular dynamics of this pivotal stage, we performed single-cell RNA sequencing (scR…

Retinoic acid modulates peritoneal macrophage function and distribution to enhance antibacterial defense during inflammation Open

Yujuan Qin, Xi Wang, Xiamin Zhang, Lin Nong, Qiyan Hou , et al. · 2025

Background Peritoneal macrophages, comprising large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs), play a vital role in maintaining immune defenses during inflammation. However, the molecular mechanisms governing th…

SARS-CoV-2-ORF-3a Mediates Apoptosis Through Mitochondrial Dysfunction Modulated by the K+ Ion Channel Open

Muhammad Suhaib Qudus, Uzair Afaq, Siyu Liu, Kailang Wu, Yu Chen , et al. · 2025

Coronavirus disease 2019 (COVID-19) causes pulmonary edema, which disrupts the lung alveoli–capillary barrier and leads to pulmonary cell apoptosis, the main cause of death. However, the molecular mechanism behind SARS-CoV-2’s apoptotic ac…

Strategies Used by SARS-CoV-2 to Evade the Innate Immune System in an Evolutionary Perspective Open

Hong Fan, Mingfu Tian, Siyu Liu, Chenglin Ye, Zhiqiang Li , et al. · 2024

By the end of 2019, the COVID-19 pandemic, resulting from the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), had diffused widely across the globe, with 770 million infected individuals and over 7 million deaths reported. In …

Palmitoylation of NLRP3 Modulates Inflammasome Activation and Inflammatory Bowel Disease Development Open

Dingwen Hu, Yuting Li, Xianyang Wang, Haimei Zou, Zonghui Li , et al. · 2024

Aberrant activity of NLRP3 has been shown associations with severe diseases. Palmitoylation is a kind of protein post-translational modification, which has been shown to regulate cancer development and the innate immune system. Here, we sh…

Association between systemic immune-inflammation index and chronic obstructive pulmonary disease: a population-based study Open

Chenglin Ye, Yuan Li, Kailang Wu, Bingzheng Shen, Chengliang Zhu · 2023

β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1 Open

Guolei Wang, Zhiqiang Li, Mingfu Tian, Xianghua Cui, Jun’e Ma , et al. · 2023

Many studies have shown that β-glucan induces a trained immune phenotype in innate immune cells to defend against bacterial and fungal infections. The specific mechanism involves cellular metabolism and epigenetic reprogramming. However, i…

Human papillomavirus genotypic characteristics of 60,685 subjects under age-expansion vaccination of the nine-valent human papillomavirus vaccine: A cross-sectional study Open

Yu Liu, Zhiqiang Li, Yuan Li, Fang Liu, Kailang Wu , et al. · 2023

The HPV positivity rate in the population remains high and tends to increase, and the age-expansion of the nine-valent HPV vaccine would contribute to reducing the threat of disease caused by HPV infection for age-eligible women. Moreover,…

Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly Open

Zhiqiang Li, Mingfu Tian, Guolei Wang, Xianghua Cui, Jun’e Ma , et al. · 2023

In the context of the global COVID-19 pandemic, the phenomenon that the elderly have higher morbidity and mortality is of great concern. Existing evidence suggests that senescence and viral infection interact with each other. Viral infecti…

Inhibition of PIKFYVE kinase interferes ESCRT pathway to suppress RNA virus replication Open

Zhen Luo, Yicong Liang, Mingfu Tian, Zhihui Ruan, Rui Su , et al. · 2023

Endosomal sorting complex required for transport (ESCRT) is essential in the functional operation of endosomal transport in envelopment and budding of enveloped RNA viruses. However, in nonenveloped RNA viruses such as enteroviruses of the…

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19 Open

Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen , et al. · 2021

LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination Open

Dingwen Hu, Yingchong Wang, Aixin Li, Qin Li, Caifeng Wu , et al. · 2021

Zika virus (ZIKV) infection can cause severe neurological disorders, including Guillain-Barre syndrome and meningoencephalitis in adults and microcephaly in fetuses. Here, we reveal that laminin receptor 1 (LAMR1) is a novel host resistanc…

Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks Open

Jian Shang, Yuan Zheng, Jiayin Mo, Wenbiao Wang, Zhen Luo , et al. · 2021

Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity. However, without tightly controlled immune responses, …

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production Open

Keli Chen, Feng Xiao, Dingwen Hu, Weiwei Ge, Mingfu Tian , et al. · 2020

SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health worldwide. Clinical data shows a disturbed type I interferon (IFN) response during the virus infection. In this study, we discovered that the nucleocapsid …

Analysis of adjunctive serological detection to nucleic acid test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis Open

Rui Liu, Xinghui Liu, Yuan Li, Huan Han, Muhammad Adnan Shereen , et al. · 2020

Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation Open

Lei You, Junbo Chen, Weiyong Liu, Qi Xiang, Zhen Luo , et al. · 2020

Enterovirus 71 (EV71) infection causes hand, foot, and mouth disease (HFMD), and even fatal neurological complications. However, the mechanisms underlying EV71 neurological pathogeneses are largely unknown. This study reveals a distinct me…

Decreased T cell populations contribute to the increased severity of COVID-19 Open

Rui Liu, Ying Wang, Jie Li, Huan Han, Zunen Xia , et al. · 2020

The value of urine biochemical parameters in the prediction of the severity of coronavirus disease 2019 Open

Rui Liu, Qingfeng Ma, Huan Han, Hanwen Su, Fang Liu , et al. · 2020

Background Among patients with coronavirus disease 2019 (COVID-19), the cases of a significant proportion of patients are severe. A viral nucleic acid test is used for the diagnosis of COVID-19, and some hematological indicators have been …

The comparative superiority of IgM-IgG antibody test to real-time reverse transcriptase PCR detection for SARS-CoV-2 infection diagnosis Open

Rui Liu, Xinghui Liu, Huan Han, Muhammad Adnan Shereen, Zhili Niu , et al. · 2020

Background As the increasing number of Corona Virus Disease 2019 (COVID-19) patients caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2), which caused an outbreak initiated from Wuhan, China in December, 2019, the clinical fe…

STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection Open

Wenbiao Wang, Dingwen Hu, Caifeng Wu, Yuqian Feng, Aixin Li , et al. · 2020

One of the fundamental reactions of the innate immune responses to pathogen infection is the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 inflammasome. The stimulator of interferon genes (STING) has the es…

Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020 Open

Rui Liu, Huan Han, Fang Liu, Zhihua Lv, Kailang Wu , et al. · 2020

Enterovirus 71 Represses Interleukin Enhancer-Binding Factor 2 Production and Nucleus Translocation to Antagonize ILF2 Antiviral Effects Open

Jing Jin, Wenbiao Wang, Sha Ai, Weiyong Liu, Yu Song , et al. · 2019

Enterovirus 71 (EV71) infection causes hand-foot-mouth disease (HFMD), meningoencephalitis, neonatal sepsis, and even fatal encephalitis in children, thereby presenting a serious risk to public health. It is important to determine the mech…

Dengue Virus Infection Activates Interleukin-1β to Induce Tissue Injury and Vascular Leakage Open

Pan Pan, Zhang Qi, Weiyong Liu, Wenbiao Wang, Zhenyang Yu , et al. · 2019

Dengue virus (DENV) infection causes several diseases ranging from dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome characterized by endothelial dysfunction, vascular leakage, and shock. Here, we identify…

EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production Open

Zhen Luo, Rui Su, Wenbiao Wang, Yicong Liang, Xiaofeng Zeng , et al. · 2019

As a neurotropic virus, human Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease (HFMD) and may develop severe neurological disorders in infants. Toll-like receptor 7 (TLR7) acts as an innate immune receptor and is also a d…

Enterovirus 71 Represses Interleukin Enhancer Binding Factor 2 Production and Nucleus Translocation to Antagonize ILF2 Antiviral Effects Open

Jing Jin, Wenbiao Wang, Sha Ai, Zhang Qi, Kailang Wu , et al. · 2019

Enterovirus 71 (EV71) infection hand-foot-mouth disease (HFMD), meningoencephalitis, neonatal sepsis, and even fatal encephalitis in children, thereby representing a serious public health hazard. It is important to determine the mechanisms…

Dengue Virus M Protein Promotes NLRP3 Inflammasome Activation To Induce Vascular Leakage in Mice Open

Pan Pan, Zhang Qi, Weiyong Liu, Wenbiao Wang, Zizhao Lao , et al. · 2019

Dengue virus (DENV) is a mosquito-borne pathogen, and infections by this virus are prevalent in over 100 tropical and subtropical countries or regions, with approximately 2.5 billion people at risk. DENV infection induces a spectrum of cli…

STING recruits NLRP3 to the ER and deubiquitinates NLRP3 to activate the inflammasome Open

Wenbiao Wang, Dingwen Hu, Yuqian Feng, Caifeng Wu, Aixin Li , et al. · 2019

One of the fundamental reactions of the innate immune responses to pathogen infection is the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 inflammasome. STING is essential for innate immune responses and in…

Hepatitis B Virus X Protein-Induced Serine Protease Inhibitor Kazal Type 1 Is Associated with the Progression of HBV-Related Diseases Open

Chengliang Zhu, Huan Han, Jie Li, Limin Xu, Fang Liu , et al. · 2019

Objective . Hepatitis B virus (HBV) causes inflammation of the liver and is the leading cause of both liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Serine protease inhibitor Kazal type 1 (SPINK1) is an acute-phase response prote…

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