Kunmei Ji
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View article: Identification of three novel mite allergens, Der f 42, Der f 43, and Der f 44, from Dermatophagoides farinae by gelsolin interactome analysis
Identification of three novel mite allergens, Der f 42, Der f 43, and Der f 44, from Dermatophagoides farinae by gelsolin interactome analysis Open
GIA revealed 3 novel HDM proteins in this study and represents a new strategy for discovering and studying allergens.
View article: The novel house dust mite allergen Der p 39 exacerbates atopic dermatitis-like inflammation in mice by inducing skin barrier dysfunction
The novel house dust mite allergen Der p 39 exacerbates atopic dermatitis-like inflammation in mice by inducing skin barrier dysfunction Open
View article: Impacts of COVID-19 lockdown on PM2.5-bound polycyclic aromatic hydrocarbons in Hohhot, Northern China: characteristics, sources, and source-specific health risks
Impacts of COVID-19 lockdown on PM2.5-bound polycyclic aromatic hydrocarbons in Hohhot, Northern China: characteristics, sources, and source-specific health risks Open
Quantifying the impacts of reduction strategies on PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) is essential for reducing the health risks of PM2.5. The COVID-19 lockdown provided an opportunity to reveal the q…
View article: Unraveling the Degradation of Deoxynivalenol in Wheat by Sodium Bicarbonate Assisted Cold Plasma (Sb-Cp): A Combined Reactive Molecular Dynamics Simulation and Experimental Validation
Unraveling the Degradation of Deoxynivalenol in Wheat by Sodium Bicarbonate Assisted Cold Plasma (Sb-Cp): A Combined Reactive Molecular Dynamics Simulation and Experimental Validation Open
View article: Effects of polysaccharide of Atractylodes macrocephala Koidz combined with microecological preparations on growth performance and serum hormone levels of pigs
Effects of polysaccharide of Atractylodes macrocephala Koidz combined with microecological preparations on growth performance and serum hormone levels of pigs Open
View article: Study on the Migration and Removal Behavior of Intracellular and Extracellular Antibiotic Resistance Genes in the Advanced Oxidation Sludge Dewatering Process
Study on the Migration and Removal Behavior of Intracellular and Extracellular Antibiotic Resistance Genes in the Advanced Oxidation Sludge Dewatering Process Open
View article: Dental caries prevalence and caries-associated risk factors of students aged 12–15 in Xide County of Liangshan Prefecture, China: a cross-sectional study
Dental caries prevalence and caries-associated risk factors of students aged 12–15 in Xide County of Liangshan Prefecture, China: a cross-sectional study Open
Objective About 2 billion people have caries in permanent teeth, and 514 million children have caries in primary teeth worldwide. Regional disparities in caries prevalence are evident in various areas of China. A comprehensive understandin…
View article: Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis
Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis Open
Background: Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity IgE Fc receptor (Fc…
View article: Identification of an immunodominant IgE epitope of Der f 40, a novel allergen of Dermatophagoides farinae
Identification of an immunodominant IgE epitope of Der f 40, a novel allergen of Dermatophagoides farinae Open
View article: Formononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions
Formononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions Open
Formononetin (FNT) is a plant-derived isoflavone natural product with anti-inflammatory, antioxidant, and anti-allergic properties. We showed previously that FNT inhibits immunoglobulin E (IgE)-dependent mast cell (MC) activation, but the …
View article: Identification of an immunodominant IgE epitope of Der p 39, a novel allergen of Dermatophagoides pteronyssinus
Identification of an immunodominant IgE epitope of Der p 39, a novel allergen of Dermatophagoides pteronyssinus Open
View article: Plant-Derived Molecule 4-Methylumbelliferone Suppresses FcεRI-Mediated Mast Cell Activation and Allergic Inflammation
Plant-Derived Molecule 4-Methylumbelliferone Suppresses FcεRI-Mediated Mast Cell Activation and Allergic Inflammation Open
Mast cells (MCs) are an important treatment target for high-affinity IgE Fc receptor (FcεRI)-mediated allergic diseases. The plant-derived molecule 4-methylumbelliferone (4-MU) has beneficial effects in animal models of inflammation and au…
View article: Levitt’s CO breath test in the differential diagnosis of chronic isolated hyperbilirubinemia
Levitt’s CO breath test in the differential diagnosis of chronic isolated hyperbilirubinemia Open
A key component of the differential diagnosis of isolated hyperbilirubinemia (HB) is distinguishing between hemolytic and non-hemolytic types. Routine hemolysis screening markers have unsatisfactory sensitivity and specificity. Erythrocyte…
View article: Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39
Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39 Open
Accurate house dust mite (HDM) genome and transcriptome data would promote our understanding of HDM allergens. We sought to assemble chromosome-level genome and precise transcriptome profiling of Dermatophagoides farinae and identif…
View article: Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis
Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis Open
Background Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity IgE Fc receptor (Fcε…
View article: Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis
Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis Open
Background: Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity IgE Fc receptor (Fc…
View article: A critical COVID-19 patient managed with timely evaluation, early prone positioning ventilation, and a multi-pronged pharmacotherapy
A critical COVID-19 patient managed with timely evaluation, early prone positioning ventilation, and a multi-pronged pharmacotherapy Open
There is not yet a standard drug regimen for the treatment of coronavirus disease 2019 (COVID-19) patients. Here, we summarize our experience and successful treatment plan with a critical COVID-19 patient who required mechanical ventilatio…
View article: Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review)
Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review) Open
A severe immune response in patients with coronavirus disease 2019 (COVID-19) can cause a potentially lethal unconstrained inflammatory cytokine storm, known as cytokine release syndrome (CRS). The present study provides an overview of the…
View article: Ribonuclease T2 from Aspergillus fumigatus promotes T helper type 2 responses through M2 polarization of macrophages
Ribonuclease T2 from Aspergillus fumigatus promotes T helper type 2 responses through M2 polarization of macrophages Open
Allergic bronchopulmonary aspergillosis (ABPA) is an allergic immunological response to Aspergillus fumigatus (Af) exposure, which induces a strong T helper 2 (Th2) response via mechanisms that have yet to be elucidated. The aim of the pre…
View article: Aurora kinase inhibitor tozasertib suppresses mast cell activation <i>in vitro</i> and <i>in vivo</i>
Aurora kinase inhibitor tozasertib suppresses mast cell activation <i>in vitro</i> and <i>in vivo</i> Open
Background and Purpose Mast cells are important in allergic reactions. Here, we assessed the anti‐allergic effects of the anti‐cancer drug tozasertib specifically regarding regulatory effects on mast cell activation. Experimental Approach …
View article: Identification of immunodominant IgE epitopes of the major house dust mite allergen Der f 24
Identification of immunodominant IgE epitopes of the major house dust mite allergen Der f 24 Open
Previously, a ubiquinol‑cytochrome c reductase binding protein (UQCRB) homolog was identified in the house dust mite (HDM) species Dermatophagoides farinae (Der f) as a major allergen. In the present study, the immunodominant immunoglobuli…
View article: CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation
CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation Open
Palbociclib suppresses IgE-mediated mast cell activation in vitro and in vivo, suggesting that it may be developed into a therapy for mast cell-mediated allergic diseases via inhibition of mast cell degranulation.
View article: Antipsychotic agent pimozide promotes reversible proliferative suppression by inducing cellular quiescence in liver cancer
Antipsychotic agent pimozide promotes reversible proliferative suppression by inducing cellular quiescence in liver cancer Open
The antipsychotic drug pimozide has been found to exhibit anticancer effects. Previously, it was demonstrated that pimozide inhibits hepatocellular carcinoma (HCC) cell growth, but its pharmacodynamic characteristics remain unclear. The ai…
View article: Identification of Der f 23 as a new major allergen of Dermatophagoides farinae
Identification of Der f 23 as a new major allergen of Dermatophagoides farinae Open
House dust mites (HDM) are common allergen sources worldwide. At present, 32 of the 37 internationally recognized HDM allergen groups have been identified in Dermatophagoides farinae. The present study study describes the identification of…
View article: Identification of immunodominant IgE binding epitopes of Der p 24, a major allergen of Dermatophagoides pteronyssinus
Identification of immunodominant IgE binding epitopes of Der p 24, a major allergen of Dermatophagoides pteronyssinus Open
We identified Der p 24 as a major HDM allergen with strong IgE binding activity via an immunodominant IgE epitope in the N-terminal 32-residue region, which triggers IgE production in vivo. The identified Der p 24 epitope may support HDM a…
View article: Enhanced sensitivity of capture IgE‑ELISA based on a recombinant Der f 1/2 fusion protein for the detection of IgE antibodies targeting house dust mite allergens
Enhanced sensitivity of capture IgE‑ELISA based on a recombinant Der f 1/2 fusion protein for the detection of IgE antibodies targeting house dust mite allergens Open
The detection of allergen‑specific immunoglobulin (Ig)E is an important method for the diagnosis of IgE‑mediated allergic diseases. The sensitivity of the indirect IgE‑ELISA method against allergen extracts is limited by interference from …
View article: Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells
Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells Open
Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators. Among them, IgE plays a vital role in the develop…
View article: Human erythrocyte lifespan measured by Levitt’s CO breath test with newly developed automatic instrument
Human erythrocyte lifespan measured by Levitt’s CO breath test with newly developed automatic instrument Open
Existing standard techniques for erythrocyte (RBC) lifespan measurement, such as quantitation of labeling with isotopes or biotin, are cumbersome and time-consuming. Given that endogenous CO originates mainly from degraded RBCs, a team lea…
View article: Cell phone-based online biochemistry and molecular biology medical education curriculum
Cell phone-based online biochemistry and molecular biology medical education curriculum Open
We thank Metcalf et al. for the innovative education technology they described in their paper ‘Effectiveness of an online curriculum for medical students on genetics, genetic testing and counseling...
View article: Suggestions to Improve Medical Education in China-Learning from Diagnostic Errors of Kidney Diseases
Suggestions to Improve Medical Education in China-Learning from Diagnostic Errors of Kidney Diseases Open