Kedong Zhang
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View article: Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model
Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model Open
Digoxin can protect CS-induced COPD and prevent CS-induced EMT possibly through HIF-1α/TGF-β1/Smad3 signaling pathway in mice. This study suggests HIF1-α could be a potential intervention target for COPD prevention and treatment, especiall…
View article: A rare case of Castleman disease presented with diffuse ground glass nodules in both lungs: Case report
A rare case of Castleman disease presented with diffuse ground glass nodules in both lungs: Case report Open
Rationale: Castleman disease (CD) is a rare chronic lymphoproliferative disorder with unclear etiology and pathogenesis. It is divided into unicentric CD, which involved a single enlarged lymph node or region of lymph nodes, and multicentr…
View article: Frictional Behavior and Fluid Flow Simulation Analysis of Textured ZrO2–Polyetheretherketone Artificial Knee Joints
Frictional Behavior and Fluid Flow Simulation Analysis of Textured ZrO2–Polyetheretherketone Artificial Knee Joints Open
ZrO2 ceramics, known for their high strength and wear resistance, are ideal for artificial joints. This study enhanced the friction performance of these joints by fabricating textured structures (50 μm width and 20–25 μm depth) on the cera…
View article: Analysis of Flow Instability and Mechanical Energy Loss of Fluid Field in Fluid Momentum Wheel
Analysis of Flow Instability and Mechanical Energy Loss of Fluid Field in Fluid Momentum Wheel Open
A new type of anti-rolling device denoted as a fluid momentum wheel (FMW) is proposed to address the limitations of traditional gyrostabilizers in reducing the roll responses of floating platforms in waves. The proposed device is based on …
View article: HIF-1α inhibitor protects against cigarette smoke-induced COPD development in mice
HIF-1α inhibitor protects against cigarette smoke-induced COPD development in mice Open
Hypoxia-inducible factor-1α (HIF-1α) plays an important regulatory role in inflammatory and hypoxic diseases. Higher HIF-1α level was found in lungs of chronic obstructive pulmonary disease (COPD) patients, however, its role in cigarette s…
View article: A rare case of Castleman disease presented with diffuse ground glass nodules in both lungs
A rare case of Castleman disease presented with diffuse ground glass nodules in both lungs Open
Castleman disease(CD), also known as giant lymphadenopathy or angiofollicular lymphadenopathy, was firstly reported by Castleman in 1954[1]. CD is a rare chronic lymphoproliferative disease, and its etiology and pathogenesis is still not c…
View article: Influence of parameter selection strategy on tool wear when milling 3D printed functionally graded materials with textured tool under minimum quantity lubrication
Influence of parameter selection strategy on tool wear when milling 3D printed functionally graded materials with textured tool under minimum quantity lubrication Open
Functionally Graded Materials (FGMs) is a promising engineering material, which is highly desirable in extreme environments of aerospace, nuclear and bio-implants. Although the surface accuracy and quality of 3D printed Ni-Fe FGMs can meet…
View article: HIF-1α Contributes to the Progression of Chronic Obstructive Pulmonary Disease
HIF-1α Contributes to the Progression of Chronic Obstructive Pulmonary Disease Open
Background Hypoxia-inducible factor-1α (HIF-1α) plays an important regulatory role in inflammatory and hypoxic diseases. Higher HIF-1α level was found in lungs of chronic obstructive pulmonary disease (COPD) patients, however, its role in …
View article: Prediction of Nonlinear Micro-Milling Force with a Novel Minimum Uncut Chip Thickness Model
Prediction of Nonlinear Micro-Milling Force with a Novel Minimum Uncut Chip Thickness Model Open
The minimum uncut chip thickness (MUCT), dividing the cutting zone into the shear region and the ploughing region, has a strong nonlinear effect on the cutting force of micro-milling. Determining the MUCT value is fundamental in order to p…
View article: An Improved Cutting Force Model in Micro-milling Considering the Comprehensive Effect of Tool Runout, Size Effect and Tool Wear
An Improved Cutting Force Model in Micro-milling Considering the Comprehensive Effect of Tool Runout, Size Effect and Tool Wear Open
Tool runout, cutting edge radius-size effect and tool wear have significant impacts on the cutting force of micro-milling. In order to predict the micro-milling force and the machining performance related to the cutting force, it is necess…
View article: Sputum mucin 1 is increased during the acute phase of chronic obstructive pulmonary disease exacerbation
Sputum mucin 1 is increased during the acute phase of chronic obstructive pulmonary disease exacerbation Open
Unlike pure bacterial induced lung inflammation, both sputum MUC1 CT and EC fragments are increased during acute exacerbation of COPD. The clinical benefits from measuring the changes of various sputum MUC1 fragments in AECOPD need to be e…
View article: Newfoundland shrimp waste utilization and dispersant generation
Newfoundland shrimp waste utilization and dispersant generation Open
This research focused on the utilization of Newfoundland shrimp waste as a premium and low-cost nitrogen source for microbial growth through an enzymatic hydrolysis process. In addition, the enzymatically hydrolyzed shrimp waste was used t…