Explanipedia

Advancing disease-modifying therapies for Parkinson’s disease: Current strategies and future directions Open

Kaimin Wu, Yizongheng Zhang, Tingting Wang, Jiayi Wu, Yuyuan Huang , et al. · 2025

MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer’s disease model Open

Haishan Jiao, Yi‐Jun Ge, Lin Huang, Ying Liu, Bang‐Sheng Wu , et al. · 2025

Background Alzheimer’s disease (AD) is the most common type of dementia. Genetic polymorphisms are associated with altered risks of AD onset, pointing to biological processes and potential targets for interventions. Consistent with the imp…

Zbtb7b defines a compensatory mechanism in MASLD‐related HCC progression by suppressing H19‐mediated hepatic lipid deposition Open

Yinglin Han, Kaimin Wu, Peng Xin, Yinkun Fu, Wenyan Li , et al. · 2024

Hepatocellular carcinoma (HCC) is a widely prevalent type of primary liver cancer. However, strategies for pretumor intervention are still limited. In this study, a liver‐specific Zbtb7b knockout mouse model was used to evaluate the role o…

Efficiency Improvement of In Vitro Chromosome Doubling in Melon haploid Open

yan lelong, zhu songyu, Kaimin Wu, Huang Yao, zhang yaomei , et al. · 2024

In vitro chromosome doubling (ivCD) using colchicine is a main method for melon haploid chromosome doubling, but its doubling efficiency remains low. In this study, we aimed to increase the efficiency of melon haploid doubling. In Experime…

Novel diagnostic and prognostic approach for rapidly progressive dementias: Indicators based on amyloid/tau/neurodegeneration (ATN) framework Open

Yuan Cheng, Shu‐Fen Chen, Ya‐Ru Zhang, Yu Guo, Kaimin Wu , et al. · 2024

Aims Apply established cerebrospinal fluid (CSF) and serum biomarkers and novel combined indicators based on the amyloid/tau/neurodegeneration (ATN) framework to improve diagnostic and prognostic power in patients with rapidly progressive …

Analysis of clinical characteristics and imagological features of the aortic dissection patients with negative D-dimer results Open

Zhi-Xiang Zhang, Lilan Wang, Xin Su, Yuling Zhou, Kaimin Wu , et al. · 2023

Background D-dimer (DD) is a vital biomarker to rule out the diagnosis of aortic dissection (AD). However, the DD level in some patients with AD is not high in clinical practice, which often leads to missed diagnosis; therefore, understand…

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes Open

Y Liu, Kaimin Wu, Yinkun Fu, Wenyan Li, Xu-Yun Zhao · 2023

Primary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid me…

Recent Progress in Single-Nucleotide Polymorphism Biosensors Open

Kaimin Wu, Feizhi Kong, Jingjing Zhang, Ying Tang, Yao Chen , et al. · 2023

Single-nucleotide polymorphisms (SNPs), the most common form of genetic variation in the human genome, are the main cause of individual differences. Furthermore, such attractive genetic markers are emerging as important hallmarks in clinic…

Transcatheter aortic valve implantation for patients with heyde syndrome: A literature review of case reports Open

Lilan Wang, Kaimin Wu, Weimei Ou, Xin Su, Guangfeng Sun , et al. · 2023

Acute myocardial infarction after inactivated COVID-19 vaccination: a case report and literature review Open

Weimei Ou, Bin Wang, Guoming Zhang, Licheng Ding, Zhixian Liu , et al. · 2023

A number of vaccines have been developed and deployed globally to restrain the spreading of the coronavirus disease 2019 (COVID-19). The adverse effect following vaccination is an important consideration. Acute myocardial infarction (AMI) …

Case Report: A balloon-based technique to remove a pearl-like embolus out of the coronary artery Open

Kaimin Wu, Lianglong Chen, Licheng Ding, Bin Wang · 2023

Coronary embolism is considered a rare non-atherosclerotic etiology of acute myocardial infarction, whereas atrial fibrillation is the main etiology of coronary embolism. We report a rare case of a patient with coronary embolism with a spe…

Systematic assessment of plasma biomarkers in spinocerebellar ataxia Open

Xue‐Ning Shen, Kaimin Wu, Yuyuan Huang, Yu Guo, Shu‐Yi Huang , et al. · 2023

Plasma NfL may serve as a sensitive biomarker for SCA, and its level is elevated in the pre-ataxic stage. The different performance of NfL and GFAP indicates differences in the underlying neuropathology of SCA and MSA-C. Moreover, amyloid …

The proGnostic role of caRdiac rehAbilitation in patients with left ventriCular anEurysm formation after anterior myocardial infarction (the GRACE study): Study rationale and design of a prospective randomized controlled trial Open

Peng Zhang, Xiaofeng Ge, Zhaokai Li, Meiling Nie, Jing Yu , et al. · 2023

Background Cardiac rehabilitation (CR) is an essential intervention after acute myocardial infarction (MI). However, it is still unclear whether patients with left ventricular aneurysm (LVA) formation after anterior MI would benefit from C…

Recent progress of microfluidic chips in immunoassay Open

Kaimin Wu, Xuliang He, Jinglei Wang, Ting Pan, Ran He , et al. · 2022

Microfluidic chip technology is a technology platform that integrates basic operation units such as processing, separation, reaction and detection into microchannel chip to realize low consumption, fast and efficient analysis of samples. I…

Omics-based biomarkers discovery for Alzheimer's disease Open

Qiaolifan Aerqin, Zuo-Teng Wang, Kaimin Wu, Xiao‐Yu He, Qiang Dong , et al. · 2022

Development and shelf life stability of new products for Pacific saury (Cololabis saira) Open

Chao-Chin Huang, Chih‐Yao Hou, Anil Kumar Patel, Ti-Wan Kung, Cian-Huei Song , et al. · 2022

Tauopathies: new perspectives and challenges Open

Yi Zhang, Kaimin Wu, Yang Liu, Qiang Dong, Jin‐Tai Yu · 2022

Modifiable Risk Factors for Incident Dementia and Cognitive Impairment: An Umbrella Review of Evidence Open

Ya-Ru Zhang, Wei Xu, Wei Zhang, Hui-Fu Wang, Ya‐Nan Ou , et al. · 2021

Dementia and cognitive impairment can be attributed to both genetic and modifiable risk factors. Recently, considerable evidence emerged and urgently require standardized evaluation. To address it, we conducted an umbrella review of prospe…

Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis Open

Yanjie Jia, Yan Zhou, Lulu Wen, Yanfei Li, Kaimin Wu , et al. · 2021

Mesenchymal stem cell (MSC) transplantation is a promising treatment strategy for spinal cord injury, but immunological rejection and possible tumor formation limit its application. The therapeutic effects of MSCs mainly depend on their re…

Chitosan-miRNA functionalized microporous titanium oxide surfaces via a layer-by-layer approach with a sustained release profile for enhanced osteogenic activity Open

Kaimin Wu, Mengyuan Liu, Nan Li, Li Zhang, Fanhui Meng , et al. · 2020

Chitosan-miRNA Functionalized Microporous Titanium Oxide Surface via A Layer-by-layer Approach with a Sustained Release Profile for Enhanced Osteogenic Activity Open

Kaimin Wu, Mengyuan Liu, Nan Li, Li Zhang, Fanhui Meng , et al. · 2020

Background: Biofunctionalization of titanium implants for high osteogenic ability holds the hope for advanced implant of promoted osseointegration, especially in the compromised bone condition. In this study, using chitosan-miRNA (CS-miRNA…

Free thyroxine level is associated with both relapse rate and poor neurofunction in first-attack Neuromyelitis Optica Spectrum Disorder (NMOSD) patients Open

Qianyi He, Lifeng Li, Yanfei Li, Yanhui Lu, Kaimin Wu , et al. · 2019

Triglyceride Level Is an Independent Risk Factor in First-Attacked Neuromyelitis Optica Spectrum Disorders Patients Open

Kaimin Wu, Lulu Wen, Ranran Duan, Yanfei Li, Yaobing Yao , et al. · 2019

Objective: To investigate prospective associations between triglyceride (TG) level and prognosis of first-attacked patients with neuromyelitis optica spectrum disorders (NMOSD). Methods: This retrospective study included 196 …

Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Recovery Following Spinal Cord Injury via Improvement of the Integrity of the Blood-Spinal Cord Barrier Open

Yanhui Lu, Yan Zhou, Ruiyi Zhang, Lulu Wen, Kaimin Wu , et al. · 2019

Mesenchymal stem cell (MSC) transplantation has been shown to represent a potential treatment for traumatic spinal cord injury (SCI). However, there are several obstacles that need to be overcome before MSCs can be considered for clinical …

MicroRNA Let-7f-5p Promotes Bone Marrow Mesenchymal Stem Cells Survival by Targeting Caspase-3 in Alzheimer Disease Model Open

Linlin Han, Yan Zhou, Ruiyi Zhang, Kaimin Wu, Yanhui Lu , et al. · 2018

Widespread death of transplanted mesenchymal stem cells (MSCs) hampers the development of stem cell therapy for Alzheimer disease (AD). Cell pre-conditioning might help cope with this challenge. We tested whether let-7f-5p-modified MSCs co…

Blood urea nitrogen (BUN) and creatinine in rats after burn. Open

Feng Yafei, Yi Liu, Lin Wang, Xiaoqing Cai, Wang Dexin , et al. · 2015

Analysis of burn-induced late renal dysfunction evidenced by BUN and creatinine (A–B) at different time points of 3 h, 6 h, 24 h, 48 h and 72 h and (C–D) with different treatments at 72 h postburn. The data showed that burn i…

Schematic diagram showed the mediation of burn-induced sustained ROS overproduction on p38 MAPK and Akt expression and apoptotic pathway, which may be the mechanism of late acute renal failure. Open

Yafei Feng, Yi Liu, Lin Wang, Xiaoqing Cai, Dexin Wang , et al. · 2015

Schematic diagram showed the mediation of burn-induced sustained ROS overproduction on p38 MAPK and Akt expression and apoptotic pathway, which may be the mechanism of late acute renal failure.

Chitosan/siCkip-1 biofunctionalized titanium implant for improved osseointegration in the osteoporotic condition Open

Li Zhang, Kaimin Wu, Wen Song, Haiyan Xu, Ran An , et al. · 2015

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