Kaining Chen
YOU?
Author Swipe
View article: T-cadherin deprivation in endothelial cells promotes vascular injury in Kawasaki disease through SOD2/ROS/NLRP3 pathway-mediated pyroptosis
T-cadherin deprivation in endothelial cells promotes vascular injury in Kawasaki disease through SOD2/ROS/NLRP3 pathway-mediated pyroptosis Open
Kawasaki disease (KD) is an acute febrile systemic vasculitis associated with the development of coronary artery lesion and coronary artery aneurysm. This condition is characterized by sustained vascular inflammation and endothelial dysfun…
View article: Effects of cyanobacterial growth and decline on dissolved organic matter and endogenous nutrients release at the sediment–water interface
Effects of cyanobacterial growth and decline on dissolved organic matter and endogenous nutrients release at the sediment–water interface Open
Understanding the interactions between dissolved organic matter (DOM) and nutrient behavior during cyanobacterial events has important implications for water management. Therefore, we constructed a simulated cyanobacterial growth and decli…
View article: LINC00461 SNPs rs933647 and rs201864123 modify the risk of adenoid hypertrophy susceptibility for children in South China
LINC00461 SNPs rs933647 and rs201864123 modify the risk of adenoid hypertrophy susceptibility for children in South China Open
Background Adenoidal hypertrophy (AH) is commonly observed in childhood and closely linked to obstructive sleep apnea (OSA). Despite the high prevalence of AH, its pathophysiological mechanisms remain incompletely understood. We attempt to…
View article: The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling
The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling Open
Single-exosome profiling and exosome subpopulations of RA by PBA yielded significant differential gene FN1, which provides new possibilities for diagnostic screening of RA.
View article: An interventional study of digital therapy on blood glucose and weight management in Chinese patients with type 2 diabetes
An interventional study of digital therapy on blood glucose and weight management in Chinese patients with type 2 diabetes Open
Objective Our study aimed to evaluate the effectiveness of a 3‐months digital therapy (DTx) intervention in the real world for the management of blood glucose in 3,902 Chinese patients with type 2 diabetes (T2D) in Lingshui, Hainan. Method…
View article: Selective Effect of DNA N6-Methyladenosine Modification on Transcriptional Genetic Variations in East Asian Samples
Selective Effect of DNA N6-Methyladenosine Modification on Transcriptional Genetic Variations in East Asian Samples Open
Genetic variations and DNA modification are two common dominant factors ubiquitous across the entire human genome and induce human disease, especially through static genetic variations in DNA or RNA that cause human genetic diseases. DNA N…
View article: Progression of gestational diabetes mellitus to pregnancy-associated fulminant type 1 diabetes: a case report
Progression of gestational diabetes mellitus to pregnancy-associated fulminant type 1 diabetes: a case report Open
PF is characterized by poor maternal and infant outcomes and a high stillbirth rate. Blood glucose should be regularly monitored in pregnant women with GDM. A sudden increase in blood glucose may indicate the possibility of PF, which needs…
View article: Case report: A rare combination of aldosterone-secreting adrenocortical carcinoma and papillary thyroid carcinoma with Graves’ disease
Case report: A rare combination of aldosterone-secreting adrenocortical carcinoma and papillary thyroid carcinoma with Graves’ disease Open
Adrenocortical carcinoma (ACC) is a rare malignancy originating in the adrenal glands, aldosterone-producing ACC, even rarer. Papillary thyroid carcinoma (PTC), by contrast, accounts for the majority of thyroid carcinomas. We herein descri…
View article: Contribution of body mass index, waist circumference, and 25-OH-D3 on the risk of pre-diabetes mellitus in the Chinese population
Contribution of body mass index, waist circumference, and 25-OH-D3 on the risk of pre-diabetes mellitus in the Chinese population Open
This study aimed to investigate the associations between body mass index (BMI), waist circumference (WC), 25-hydroxy-vitamin D3 (25-OH-D3), and the risk of pre-diabetes mellitus (PDM), as well as their predictive values in identifying PDM.…
View article: Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation
Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation Open
Introduction: In obesity-related type 2 diabetes mellitus (T2DM), M1 macrophages aggravate chronic inflammation and insulin resistance. ISG15-conjugation enzyme E2L6 (Ube2L6) has been demonstrated as a promoter of obesity and insulin resis…
View article: Duplicated adrenal veins in primary aldosteronism misdiagnosed with ectopic aldosteronoma due to apparent bilateral aldosterone suppression
Duplicated adrenal veins in primary aldosteronism misdiagnosed with ectopic aldosteronoma due to apparent bilateral aldosterone suppression Open
AVS is the gold standard accepted for PA subtyping, but sometimes when apparent bilateral aldosterone suppression is present, it can give ambiguous results. Duplicated right adrenal veins, may impact results, thus, AVS may not accurately p…
View article: LASSO-based machine learning algorithm to predict the incidence of diabetes in different stages
LASSO-based machine learning algorithm to predict the incidence of diabetes in different stages Open
We established early warning models for prediabetes and diabetes, which can help identify prediabetes and diabetes high-risk populations in advance.
View article: Adherence to Blood Glucose Self-Monitoring Guidance and Glycemic Control in Chinese Patients with Type 2 Diabetes Mellitus Initiating Basal Insulin: An mHealth-Based Prospective Cohort Study (Preprint)
Adherence to Blood Glucose Self-Monitoring Guidance and Glycemic Control in Chinese Patients with Type 2 Diabetes Mellitus Initiating Basal Insulin: An mHealth-Based Prospective Cohort Study (Preprint) Open
BACKGROUND Diabetes has become a severe health threat in China, owing to its increasing prevalence, long-term morbidity, and mortality. OBJECTIVE This study evaluated the association between adherence to blood glucose self-monitoring gu…
View article: Spatial distribution and influencing factors of odorous compounds during algal blooms in the littoral zones of Lake Chaohu
Spatial distribution and influencing factors of odorous compounds during algal blooms in the littoral zones of Lake Chaohu Open
为探究湖滨带藻类水华期水体异味物质的空间分布规律,2019年6-10月对巢湖湖滨带水体理化参数和异味物质进行月度调查,分析湖滨带水体异味物质的空间分布特征,并探讨影响其空间分布差异的主要因素。结果表明: 巢湖湖滨带藻类水华期水体异味物质浓度在空间上总体表现为西北部湖区最高,南部湖区次之,东北部湖区和北部湖区最低的分布特征,藻类生物量高低及其分解是水体异味物质产生空间分布差异的主要原因。风向和风速间接影响了湖滨带水体异味物质的空间分布,其中北部湖区受风速和风向的影响最为明显,…
View article: Thymic stromal lymphopoietin induces platelet mitophagy and promotes thrombosis in Kawasaki disease
Thymic stromal lymphopoietin induces platelet mitophagy and promotes thrombosis in Kawasaki disease Open
Summary Kawasaki disease (KD) is an acute systemic vasculitis primarily affecting infants and children. Activated platelets predispose patients to coronary artery structural lesions that may lead to thrombotic cardiovascular events. To dis…
View article: Association between Rab31/rs9965664 polymorphism and immunoglobulin therapy resistance in patients with Kawasaki disease
Association between Rab31/rs9965664 polymorphism and immunoglobulin therapy resistance in patients with Kawasaki disease Open
Background Kawasaki disease (KD) is an acute febrile systemic vasculitis affecting infants and young children. A high dose of intravenous immunoglobulin (IVIG) is the first-line strategy for patients with KD to reduce persistent inflammati…