Kaiqin Chen
YOU?
Author Swipe
View article: Causal associations between biomarkers and depression: A Mendelian randomization study
Causal associations between biomarkers and depression: A Mendelian randomization study Open
Depression is one of the most prevalent and debilitating mental health conditions worldwide. Biomarkers have received considerable attention in depression research, to provide breakthroughs in early diagnosis, pathophysiological understand…
View article: Association between cigarette smoking and hearing loss: A cross-sectional study from the NHANES database
Association between cigarette smoking and hearing loss: A cross-sectional study from the NHANES database Open
There was a significant association between smoking and hearing loss, with maybe more significant associations with all three types of hearing loss in male smokers and a significant relationship between smoking and hearing loss in the midd…
View article: A study on adverse events of botulinum toxin type A in real‐world applications: A FAERS database analysis
A study on adverse events of botulinum toxin type A in real‐world applications: A FAERS database analysis Open
Aims Botulinum toxin type A (BoNT‐A) is widely used for its efficacy in treating a variety of neuromuscular disorders. However, data on its safety and adverse events (AEs) in real‐world settings remain limited. The Food and Drug Administra…
View article: The protective effects of cheese intake on joint pain and underlying biomarkers: Insights from the Mendelian randomization
The protective effects of cheese intake on joint pain and underlying biomarkers: Insights from the Mendelian randomization Open
This study aimed to investigate the relationship between cheese consumption and the risk of joint pain, as well as to assess the mediating role of biomarkers. Utilizing Mendelian randomization methods, we analyzed data from the UK Biobank …
View article: Beyond pain: The surprising connection between tramadol and depression
Beyond pain: The surprising connection between tramadol and depression Open
Background: Tramadol, a centrally acting analgesic with a dual mechanism, is frequently prescribed for pain management, including in cancer patients. However, its association with depression, a multifactorial condition influenced by geneti…
View article: Spatio‐Temporal Change of Skin and Oral Microbiota: A Longitudinal Study of Microbial Diversity and Stability
Spatio‐Temporal Change of Skin and Oral Microbiota: A Longitudinal Study of Microbial Diversity and Stability Open
The human skin and oral cavity harbor complex microbial communities, which exist in dynamic equilibrium with the host's physiological state and the external environment. This study investigates the microbial atlas of human skin and oral ca…
View article: Noise and the risk of tinnitus: A two‐sample Mendelian randomized study
Noise and the risk of tinnitus: A two‐sample Mendelian randomized study Open
Objectives Observational studies imply that noise may increase the likelihood of developing tinnitus. However, no causal relationship has been established between the two using Mendelian randomization (MR) analysis, we aimed to determine t…
View article: Comparison of the full-length sequence and sub-regions of 16S rRNA gene for skin microbiome profiling
Comparison of the full-length sequence and sub-regions of 16S rRNA gene for skin microbiome profiling Open
The skin microbiome plays a pivotal role in human health by providing protective and functional benefits. Furthermore, its inherent stability and individual specificity present novel forensic applications. These aspects have sparked consid…
View article: Association between atorvastatin and erectile dysfunction: a comprehensive analysis incorporating real-world pharmacovigilance and Mendelian randomization
Association between atorvastatin and erectile dysfunction: a comprehensive analysis incorporating real-world pharmacovigilance and Mendelian randomization Open
Background: Atorvastatin is a commonly prescribed medication for the prevention of cardiovascular diseases. Recent observational studies have suggested a potential association between atorvastatin use and the occurrence of Erectile Dysfunc…
View article: Validation and forensic application of a new 36 X-chromosomal short tandem repeat loci multiplex system
Validation and forensic application of a new 36 X-chromosomal short tandem repeat loci multiplex system Open
X-chromosomal short tandem repeats are indispensable in specific cases, distinct from autosomal and Y chromosome genetic markers. SureID® X37 is an innovative six-colour fluorescence multiplex detection system that can simultaneously ampli…
View article: Association between Lipid-Lowering Drugs and Traumatic Subdural Hemorrhage: A Mendelian Randomization Study
Association between Lipid-Lowering Drugs and Traumatic Subdural Hemorrhage: A Mendelian Randomization Study Open
Background: There are current clinical observations that atorvastatin may promote subdural hematoma resorption. We aimed to assess the causal effects of lipid-lowering agents 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibito…
View article: MAD2L2 as a novel prognostic biomarker and its correlation with immune infiltrates in glioma
MAD2L2 as a novel prognostic biomarker and its correlation with immune infiltrates in glioma Open
Background: The most common type of central nervous system tumor is glioma, the identification of Glioma biomarkers is essential. MAD2L2, which is abbreviated as MAD2-Like2, collaborates with a number of proteins to carry out numerous esse…
View article: A real-world pharmacovigilance study of FDA adverse event reporting system events for diazepam
A real-world pharmacovigilance study of FDA adverse event reporting system events for diazepam Open
Background: Diazepam, one of the benzodiazepines, is widely used clinically to treat anxiety, for termination of epilepsy, and for sedation. However, the reports of its adverse events (AEs) have been numerous, and even fatal complications …
View article: Forensic efficiency and population genetic construction of Guizhou Gelao minority from Southwest China revealed by a panel of 23 autosomal STR loci
Forensic efficiency and population genetic construction of Guizhou Gelao minority from Southwest China revealed by a panel of 23 autosomal STR loci Open
Short tandem repeats (STRs) are the most common genetic markers in forensic and human population genetics due to their high polymorphism, rapid detection, and reliable genotyping. To adapt the rapid growth of forensic DNA database and solv…
View article: Biomarkers for predicting the severity of spinal cord injury by proteomic analysis
Biomarkers for predicting the severity of spinal cord injury by proteomic analysis Open
Purpose Currently, there is a shortage of the protein biomarkers for classifying spinal cord injury (SCI) severity. We attempted to explore the candidate biomarkers for predicting SCI severity. Methods SCI rat models with mild, moderate, a…
View article: Research on Pachymaran to Ameliorate CsA-Induced Immunosuppressive Lung Injury by Regulating Microflora Metabolism
Research on Pachymaran to Ameliorate CsA-Induced Immunosuppressive Lung Injury by Regulating Microflora Metabolism Open
Pachymaran (PCP), the major medicinal constituent of Poria cocos, has a regulatory effect on immunosuppressive lung injury, but its mechanism of action with respect to gut microorganisms and their metabolites is not clear. The aim of this …
View article: Immune infiltration patterns and identification of new diagnostic biomarkers GDF10, NCKAP5, and RTKN2 in non-small cell lung cancer
Immune infiltration patterns and identification of new diagnostic biomarkers GDF10, NCKAP5, and RTKN2 in non-small cell lung cancer Open
This study aimed to identify potential biomarkers for non-small cell lung cancer (NSCLC) and analyze the role of immune cell infiltration in NSCLC. R software was used to screen differentially expressed genes (DEGs) from NSCLC datasets obt…
View article: Genetic diversity of 23 STR loci of the Guizhou Tujia ethnic minority and the phylogenetic relationships with 22 other populations
Genetic diversity of 23 STR loci of the Guizhou Tujia ethnic minority and the phylogenetic relationships with 22 other populations Open
Short tandem repeats (STR) are highly polymorphic DNA markers utilised in forensic personal identification and human population genetic research. Guizhou Tujia is one of the ancient minority groups in southwest China, however, the populati…
View article: Genetic diversity of 23 STR loci of the Guizhou Tujia ethnic minority and the phylogenetic relationships with 22 other populations
Genetic diversity of 23 STR loci of the Guizhou Tujia ethnic minority and the phylogenetic relationships with 22 other populations Open
Short tandem repeats (STR) are highly polymorphic DNA markers utilised in forensic personal identification and human population genetic research. Guizhou Tujia is one of the ancient minority groups in southwest China, however, the populati…
View article: Microbial community starters affect the profiles of volatile compounds in traditional Chinese Xiaoqu rice wine: Assement via high-throughput sequencing and gas chromatography-ion mobility spectrometry
Microbial community starters affect the profiles of volatile compounds in traditional Chinese Xiaoqu rice wine: Assement via high-throughput sequencing and gas chromatography-ion mobility spectrometry Open
Xiaoqu is a saccharifying and alcohol-producing, flavoring agent used in brewing Chinese rice wine (CRW). We combined high-throughput sequencing with headspace solid-phase microextraction-mass spectrometry-gas phase ion migration spectrome…
View article: The Relationship between the Prognostic Marker LIMA1 in Head and Neck Squamous Cell Carcinoma and Immune Infiltration
The Relationship between the Prognostic Marker LIMA1 in Head and Neck Squamous Cell Carcinoma and Immune Infiltration Open
Background. Head and neck squamous cell carcinoma (HNSC) is one of the most common malignancies, and identification of HNSC biomarkers is critical. LIM Domain And Actin Binding 1 (LIMA1) is involved in actin cytoskeleton regulation and dyn…
View article: Immunomodulatory effect of pachymaran on cyclosporine A (CsA)-induced lung injury in mice
Immunomodulatory effect of pachymaran on cyclosporine A (CsA)-induced lung injury in mice Open
Objective: To investigate the immunomodulatory effect of pachymaran on cyclosporine A (CsA)-induced lung injury in mice. Methods: (i) Fifty male BALB/c mice were randomly divided into five groups (10 mice in each group): normal control (NC…
View article: Development and validation of a nomogram for prognosis of sinonasal adenocarcinoma (a nomogram for sinonasal adenocarcinoma)
Development and validation of a nomogram for prognosis of sinonasal adenocarcinoma (a nomogram for sinonasal adenocarcinoma) Open
Background The incidence of sinonasal adenocarcinoma is low, and there are few studies on survival and prognosis. Therefore, we aim to develop and validate a prognostic model for predicting the overall survival of sinonasal adenocarcinoma …
View article: The complete mitochondrial genome of <i>Acrossocheilus yunnanensis</i> (Teleostei: Cypriniformes: Cyprinidae) and its phylogenetic position
The complete mitochondrial genome of <i>Acrossocheilus yunnanensis</i> (Teleostei: Cypriniformes: Cyprinidae) and its phylogenetic position Open
The complete mitochondrial genome of Acrossocheilus yunnanensis was determined in this study. It contained 13 protein-coding genes (PCGs), 22 tRNA, 2 rRNAs, and a control region with the base composition 31.47% A, 27.83% C, 24.65% T, and 1…