Kairan Yu
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View article: COCA-seq: genome-wide mapping of O-GlcNAc-associated open chromatin
COCA-seq: genome-wide mapping of O-GlcNAc-associated open chromatin Open
O-GlcNAcylation, a prevalent reversible post-translational modification, intricately alters non-histone proteins, influencing the organization of gene transcriptional regulation within the accessible chromatin environment. This nucleoplasm…
View article: DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions
DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions Open
O-linked β-N-acetylglucosamine (O-GlcNAc), a critical post-translational modification predominantly found in the nucleus, plays a substantial role in regulating gene expression by modulating transcription factors (TFs) activity. However, q…
View article: DNA Probe Pulldown Screening Uncovers O-GlcNAcylation Modulation of Transcription Factor DNA Interactions
DNA Probe Pulldown Screening Uncovers O-GlcNAcylation Modulation of Transcription Factor DNA Interactions Open
O-linked β-N-acetylglucosamine (O-GlcNAc), a critical post-translational modification (PTM) predominantly found in the nucleus, plays a substantial role in regulating gene expression by modulating transcription factors (TFs) activity. Howe…
View article: Prognostic model based on disulfidptosis-related lncRNAs for predicting survival and therapeutic response in bladder cancer
Prognostic model based on disulfidptosis-related lncRNAs for predicting survival and therapeutic response in bladder cancer Open
Background With poor treatment outcomes and prognosis, bladder cancer remains a focus for clinical research in the precision oncology era. However, the potential of disulfidptosis, a novel cell death mechanism, and its related long non-cod…
View article: Correction to: Elevation of O-GlcNAc and GFAT expression by nicotine exposure promotes epithelial-mesenchymal transition and invasion in breast cancer cells
Correction to: Elevation of O-GlcNAc and GFAT expression by nicotine exposure promotes epithelial-mesenchymal transition and invasion in breast cancer cells Open
View article: FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer
FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer Open
FOXA1, a transcription factor involved in epigenetic reprogramming, is crucial for breast cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic functions remain elusive. Here, we demonstrate that the O-linked β-…
View article: <scp> <i>O</i> ‐GlcNAcylation </scp> promotes topoisomerase <scp>IIα</scp> catalytic activity in breast cancer chemoresistance
<span> <i>O</i> ‐GlcNAcylation </span> promotes topoisomerase <span>IIα</span> catalytic activity in breast cancer chemoresistance Open
DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs, but clinical efficacy is often compromised due to chemoresistance. In …
View article: Application of Chemical Biology to Reveal the Function of O-GlcNAcylation in Diseases: Research Tools and Tactics
Application of Chemical Biology to Reveal the Function of O-GlcNAcylation in Diseases: Research Tools and Tactics Open
摘要 O-连接 β-N-乙酰葡糖胺(O-GlcNAc
View article: Elevation of O-GlcNAc and GFAT expression by nicotine exposure promotes epithelial‐mesenchymal transition and invasion in breast cancer cells
Elevation of O-GlcNAc and GFAT expression by nicotine exposure promotes epithelial‐mesenchymal transition and invasion in breast cancer cells Open