Kaitlin Caoili
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View article: PregMedNet: Multifaceted Maternal Medication Impacts on Neonatal Complications
PregMedNet: Multifaceted Maternal Medication Impacts on Neonatal Complications Open
While medication use is common among pregnant women, medication safety remains insufficiently characterized because studies in pregnant women are challenging due to safety concerns. The recent digitization of healthcare databases and advan…
View article: Embedding-Driven Diversity Sampling to Improve Few-Shot Synthetic Data Generation
Embedding-Driven Diversity Sampling to Improve Few-Shot Synthetic Data Generation Open
Accurate classification of clinical text often requires fine-tuning pre-trained language models, a process that is costly and time-consuming due to the need for high-quality data and expert annotators. Synthetic data generation offers an a…
View article: Sialic Acid–Siglec-E Interactions Regulate the Response of Neonatal Macrophages to Group B <i>Streptococcus</i>
Sialic Acid–Siglec-E Interactions Regulate the Response of Neonatal Macrophages to Group B <i>Streptococcus</i> Open
The mammalian Siglec receptor sialoadhesin (Siglec1, CD169) confers innate immunity against the encapsulated pathogen group B Streptococcus (GBS). Newborn lung macrophages have lower expression levels of sialoadhesin at birth compared with…
View article: Natural language processing system for rapid detection and intervention of mental health crisis chat messages
Natural language processing system for rapid detection and intervention of mental health crisis chat messages Open
View article: Selective prediction for extracting unstructured clinical data
Selective prediction for extracting unstructured clinical data Open
Objective While there are currently approaches to handle unstructured clinical data, such as manual abstraction and structured proxy variables, these methods may be time-consuming, not scalable, and imprecise. This article aims to determin…
View article: Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development
Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development Open
Members of the Sp family of transcription factors regulate gene expression via binding GC boxes within promoter regions. Unlike Sp1, which stimulates transcription, the closely related Sp3 can either repress or activate gene expression and…
View article: Selective prediction for extracting unstructured clinical data
Selective prediction for extracting unstructured clinical data Open
Electronic health records represent a large data source for outcomes research, but the majority of EHR data is unstructured (e.g. free text of clinical notes) and not conducive to computational methods. While there are currently approaches…
View article: Selective Prediction for Extracting Unstructured Clinical Data
Selective Prediction for Extracting Unstructured Clinical Data Open
View article: The novel omega‐6 fatty acid docosapentaenoic acid positively modulates brain innate immune response for resolving neuroinflammation at early and late stages of humanized APOE‐based Alzheimer’s disease models
The novel omega‐6 fatty acid docosapentaenoic acid positively modulates brain innate immune response for resolving neuroinflammation at early and late stages of humanized APOE‐based Alzheimer’s disease models Open
Background Neuroinflammation has been well established to play a crucial role in the pathogenesis and progression of Alzheimer’s disease (AD), and strong epidemiological studies have shown clear evidence of nonsteroidal anti‐inflammatory d…
View article: The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models
The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models Open
Neuroinflammation plays a crucial role in the development and progression of Alzheimer's disease (AD), in which activated microglia are found to be associated with neurodegeneration. However, there is limited evidence showing how neuroinfl…