Kaitlin J. Basham
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View article: MON-504 Investigating the Immunomodulatory Role of wnt5a in Adrenocortical Carcinoma
MON-504 Investigating the Immunomodulatory Role of wnt5a in Adrenocortical Carcinoma Open
Disclosure: Y. Imodoye: None. K. Warde: None. G. Castaneda-Hernandez: None. L. Smith: None. K. Basham: None. Adrenocortical carcinoma (ACC) is a rare, but aggressive malignancy that develops in the adrenal cortex. ACC carries a poor progno…
View article: A Stronger IMPACT on Career Development for Early- and Mid-career Faculty
A Stronger IMPACT on Career Development for Early- and Mid-career Faculty Open
Nuclear receptors are important in normal physiology and disease. Physicians and scientists who study nuclear receptors organize and attend conferences and symposia devoted to foundational and translational nuclear receptor research, but t…
View article: 7887 Non-Canonical Wnt Signaling Via WNT2B Is Critical For Adrenal Morphogenesis and Aldosterone Production
7887 Non-Canonical Wnt Signaling Via WNT2B Is Critical For Adrenal Morphogenesis and Aldosterone Production Open
Disclosure: K.S. Borges: None. D.W. Little III: None. T. de Almeida Magalhães: None. C. Ribeiro: None. K. Basham: None. T. Dumonte: None. S. Azova: None. A.E. O’Connell: None. N.A. Guagliardo: None. P.Q. Barrett: None. M. Berber: None. D. …
View article: 7427 Cellular Senescence As A Pro-Tumorigenic Process And Therapeutic Target In Adrenocortical Carcinoma
7427 Cellular Senescence As A Pro-Tumorigenic Process And Therapeutic Target In Adrenocortical Carcinoma Open
Disclosure: L. Smith: None. K. Warde: None. S. Haston: None. J. Martinez-Barbera: None. K. Basham: None. Adrenocortical carcinoma (ACC) is a rare, yet highly aggressive malignancy that arises in the adrenal cortex. Advanced age is a major …
View article: Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production
Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production Open
The steroid hormone aldosterone, produced by the zona glomerulosa (zG) of the adrenal gland, is a master regulator of plasma electrolytes and blood pressure. While aldosterone control by the renin-angiotensin system is well understood, oth…
View article: In Situ Spatial Reconstruction of Distinct Normal and Pathological Cell Populations Within the Human Adrenal Gland
In Situ Spatial Reconstruction of Distinct Normal and Pathological Cell Populations Within the Human Adrenal Gland Open
The human adrenal gland consists of concentrically organized, functionally distinct regions responsible for hormone production. Dysregulation of adrenocortical cell differentiation alters the proportion and organization of the functional z…
View article: OR16-04 Androgen Deprivation Restricts Anti-tumor Immunity In Adrenocortical Carcinoma
OR16-04 Androgen Deprivation Restricts Anti-tumor Immunity In Adrenocortical Carcinoma Open
Disclosure: K.M. Warde: None. L. Smith: None. C.J. Stubben: None. P.W. Willet: None. G. Castaneda-Hernandez: None. L. Liu: None. K. Basham: None. Adrenocortical carcinoma (ACC) is a rare cancer that is often diagnosed late and progresses r…
View article: Age-related Changes in the Adrenal Cortex: Insights and Implications
Age-related Changes in the Adrenal Cortex: Insights and Implications Open
Aging is characterized by a gradual decline in physiological function. This process affects all organs including the adrenal cortex, which normally functions to produce essential steroid hormones including mineralocorticoids, glucocorticoi…
View article: Targeting Oncogenic Wnt/β-Catenin Signaling in Adrenocortical Carcinoma Disrupts ECM Expression and Impairs Tumor Growth
Targeting Oncogenic Wnt/β-Catenin Signaling in Adrenocortical Carcinoma Disrupts ECM Expression and Impairs Tumor Growth Open
Adrenocortical carcinoma (ACC) is a rare but highly aggressive cancer with limited treatment options and poor survival for patients with advanced disease. An improved understanding of the transcriptional programs engaged in ACC will help d…
View article: Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer
Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer Open
The androgen receptor (AR) is one of the oldest therapeutic targets in oncology and continues to dominate the treatment landscape for advanced prostate cancer, where nearly all treatment regimens include some form of AR modulation. In this…
View article: Novel Candidate Regulators and Developmental Trajectory of Pituitary Thyrotropes
Novel Candidate Regulators and Developmental Trajectory of Pituitary Thyrotropes Open
The pituitary gland regulates growth, metabolism, reproduction, the stress response, uterine contractions, lactation, and water retention. It secretes hormones in response to hypothalamic input, end organ feedback, and diurnal cues. The me…
View article: Cancer Cell–Extrinsic Roles for the Androgen Receptor in Prostate Cancer
Cancer Cell–Extrinsic Roles for the Androgen Receptor in Prostate Cancer Open
Given the central role of the androgen receptor (AR) in prostate cancer cell biology, AR-targeted therapies have been the backbone of prostate cancer treatment for over 50 years. New data indicate that AR is expressed in additional cell ty…
View article: RF21 | PSAT77 ROLE OF THE TRANSCRIPTION FACTOR HHEX IN INNER ADRENAL CORTEX HOMEOSTASIS AND RESPONSE TO PROGESTERONE SIGNALING
RF21 | PSAT77 ROLE OF THE TRANSCRIPTION FACTOR HHEX IN INNER ADRENAL CORTEX HOMEOSTASIS AND RESPONSE TO PROGESTERONE SIGNALING Open
Congenital adrenal hyperplasia (CAH) is a set of defects in cortisol synthesis due to mutations in genes encoding steroidogenic enzymes. Consequently, the loss of glucocorticoid-mediated negative feedback on the HPA axis leads to chronical…
View article: OR04-2 WNT2B Deficiency Results in Hyperreninemic Hypoaldosteronism in Humans and Mice
OR04-2 WNT2B Deficiency Results in Hyperreninemic Hypoaldosteronism in Humans and Mice Open
Proper development and zonation of the adrenal cortex is intimately connected with its lifelong capacity to produce steroid hormones. Both adrenocortical development and homeostasis are mediated in part by paracrine WNT/β-catenin signaling…
View article: Targeting oncogenic Wnt/β-catenin signaling in adrenocortical carcinoma disrupts ECM expression and impairs tumor growth
Targeting oncogenic Wnt/β-catenin signaling in adrenocortical carcinoma disrupts ECM expression and impairs tumor growth Open
Adrenocortical carcinoma (ACC) is a rare, but highly aggressive cancer with limited treatment options and poor survival for patients with advanced disease. Improved understanding of transcriptional programs engaged in ACC will help direct …
View article: Senescence-Induced Immune Remodeling Facilitates Metastatic Adrenal Cancer in a Sex-Dimorphic Manner
Senescence-Induced Immune Remodeling Facilitates Metastatic Adrenal Cancer in a Sex-Dimorphic Manner Open
Aging is a carcinogen that markedly increases cancer risk, yet we have limited mechanistic understanding of cancer initiation in aged cells. Here, we demonstrate induction of the hallmark aging process cellular senescence, triggered by los…
View article: Wnt2b Is Essential for Adrenocortical Progenitor Cell Fate and Zona Glomerulosa Identity in Vivo
Wnt2b Is Essential for Adrenocortical Progenitor Cell Fate and Zona Glomerulosa Identity in Vivo Open
Dysregulation of normal adrenal structure and function contributes to a spectrum of diseases from hypoplasia to cancer. Peripheral adrenocortical progenitor cells in the zona glomerulosa (zG) centripetally migrate and differentiate to repl…
View article: SAT-LB44 WNT2B Regulates Adrenocortical Progenitor Cell Fate And Zona Glomerulosa Identity In Vivo
SAT-LB44 WNT2B Regulates Adrenocortical Progenitor Cell Fate And Zona Glomerulosa Identity In Vivo Open
Dysregulation of normal adrenal structure and function contributes to a spectrum of diseases from hypoplasia to cancer. Peripheral adrenocortical progenitor cells in the zona glomerulosa (zG) centripetally migrate and differentiate to repl…
View article: A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis
A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis Open
Spatiotemporal control of Wnt signaling is essential for the development and homeostasis of many tissues. The transmembrane E3 ubiquitin ligases ZNRF3 (zinc and ring finger 3) and RNF43 (ring finger protein 43) antagonize Wnt signaling by …