Kaitlyn N. Burke
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View article: Improved influenza vaccine responses after expression of multiple viral glycoproteins from a single mRNA
Improved influenza vaccine responses after expression of multiple viral glycoproteins from a single mRNA Open
Influenza viruses cause substantial morbidity and mortality every year despite seasonal vaccination. mRNA-based vaccines have the potential to elicit more protective immune responses, but for maximal breadth and durability, it is desirable…
View article: mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA
mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA Open
The CRISPR-Cas13 system has been proposed as an alternative treatment of viral infections. However, for this approach to be adopted as an antiviral, it must be optimized until levels of efficacy rival or exceed the performance of conventio…
View article: Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication Open
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal human diseases. Although vaccine development targeting these viruses has been accelerated substantially, there remain patients requiring treatment who…
View article: Influenza A virus segments five and six can harbor artificial introns allowing expanded coding capacity
Influenza A virus segments five and six can harbor artificial introns allowing expanded coding capacity Open
Influenza A viruses encode their genomes across eight, negative sense RNA segments. The six largest segments produce mRNA transcripts that do not generally splice; however, the two smallest segments are actively spliced to produce the esse…
View article: TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2
TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2 Open
Antiviral therapeutics are a front-line defense against virally induced diseases. Because viruses frequently mutate to escape direct inhibition of viral proteins, there is interest in targeting the host proteins that the virus must co-opt …
View article: The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro Open
While vaccines are vital for preventing COVID-19 infections, it is critical to develop new therapies to treat patients who become infected. Pharmacological targeting of a host factor required for viral replication can suppress viral spread…