Kaiwen Guo
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View article: Transcriptomic Analysis of Circular RNA as Potential Biomarkers in Diagnosing Atopic Dermatitis
Transcriptomic Analysis of Circular RNA as Potential Biomarkers in Diagnosing Atopic Dermatitis Open
Circular RNA, Atopic dermatitis, Lasso regression model, Random forest model.
View article: Determination of the Kinetic Rates and Intrinsic Nonradiative Losses in Organic Thermally Activated Delayed Fluorescence Emitters
Determination of the Kinetic Rates and Intrinsic Nonradiative Losses in Organic Thermally Activated Delayed Fluorescence Emitters Open
Knowledge of kinetic rates of intersystem crossing (ISC) k ISC , reverse ISC k rISC , singlet k S , and triplet k T relaxation processes, respectively, is indispensable for material design as well as understanding of the operation of organ…
View article: miR‑155 promotes an inflammatory response in HaCaT cells via the IRF2BP2/KLF2/NF‑κB pathway in psoriasis
miR‑155 promotes an inflammatory response in HaCaT cells via the IRF2BP2/KLF2/NF‑κB pathway in psoriasis Open
Psoriasis is a chronic inflammatory skin condition with numerous causes, including genetic, immunological and infectious factors. The course of psoriasis is long and recurrence is common; pathogenesis is not completely understood. However,…
View article: Integrative analysis of gene and microRNA expression profiles reveals candidate biomarkers and regulatory networks in psoriasis
Integrative analysis of gene and microRNA expression profiles reveals candidate biomarkers and regulatory networks in psoriasis Open
Psoriasis (PS) is a chronic inflammatory skin disease with a long course and tendency to recur, the pathogenesis of which is not fully understood. This article aims to identify the key differentially expressed genes (DEGs) and microRNA (mi…
View article: The demethylation of genes antagonized by TET1 in the regulation of the Wnt/β-catenin signaling pathway impacts the biological characteristics of colorectal cancer.
The demethylation of genes antagonized by TET1 in the regulation of the Wnt/β-catenin signaling pathway impacts the biological characteristics of colorectal cancer. Open
The TET family is a ten-eleven translocation family of dioxygenases that oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and other oxidation products to regulate DNA methylation. Our data revealed significant downregulatio…
View article: Identification of potential miR‑155 target genes in epidermal immune microenvironment of atopic dermatitis patients and their inflammatory effects on HaCaT cells
Identification of potential miR‑155 target genes in epidermal immune microenvironment of atopic dermatitis patients and their inflammatory effects on HaCaT cells Open
Atopic dermatitis (AD) is a common inflammatory skin condition and the leading cause of morbidity associated with skin conditions worldwide. For the majority of patients, AD is a lifelong disease that cannot be cured completely. Therefore,…
View article: Validating the role of PTGIS gene in colorectal cancer by bioinformatics analysis and in vitro experiments
Validating the role of PTGIS gene in colorectal cancer by bioinformatics analysis and in vitro experiments Open
View article: Crop diversity promotes the recovery of fungal communities in saline-alkali areas of the Western Songnen Plain
Crop diversity promotes the recovery of fungal communities in saline-alkali areas of the Western Songnen Plain Open
Introduction Phytoremediation is an effective strategy for saline land restoration. In the Western Songnen Plain, northeast China, soil fungal community recovery for saline phytoremediation has not been well documented among different crop…
View article: Identification of key genes and Construction of miRNA-mRNA regulatory network in Psoriasis based on Bioinformatics Analysis
Identification of key genes and Construction of miRNA-mRNA regulatory network in Psoriasis based on Bioinformatics Analysis Open
Background Psoriasis is a chronic inflammatory skin disease with a long course of disease and a tendency to relapse, and the pathogenesis is not completely clear. This article aims to identify the key differentially expressed genes and miR…
View article: The Reduction of Tau Hyperphosphorylation by Cornel Iridoid Glycosides Is Mediated by Their Influence on Calpain Activity
The Reduction of Tau Hyperphosphorylation by Cornel Iridoid Glycosides Is Mediated by Their Influence on Calpain Activity Open
Alzheimer’s disease (AD) is the most common type of dementia, and the abnormal hyperphosphorylation of the tau protein is the main component of its pathogenesis. Calpain was found to be abnormally activated in neurofibrillary tangles (NFTs…
View article: Soil Bacterial Communities of Rice is Dependent on Root Compartment Niches But Independent of Growth Stages in Mollisols of Northeast China
Soil Bacterial Communities of Rice is Dependent on Root Compartment Niches But Independent of Growth Stages in Mollisols of Northeast China Open
View article: Soil Bacterial Communities of Rice is Dependent on Root Compartment Niches But Independent of Growth Stages in Mollisols of Northeast China
Soil Bacterial Communities of Rice is Dependent on Root Compartment Niches But Independent of Growth Stages in Mollisols of Northeast China Open
View article: Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects
Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects Open
Several members of the FGF family have been identified as potential regulators of glucose homeostasis. We previously reported that a low threshold of FGF-induced FGF receptor 1c (FGFR1c) dimerization and activity is sufficient to evoke a g…
View article: Cornel Iridoid Glycoside Protects Against STAT1-Dependent Synapse and Memory Deficits by Increasing N-Methyl-D-aspartate Receptor Expression in a Tau Transgenic Mice
Cornel Iridoid Glycoside Protects Against STAT1-Dependent Synapse and Memory Deficits by Increasing N-Methyl-D-aspartate Receptor Expression in a Tau Transgenic Mice Open
P301S transgenic mice are an animal model of tauopathy and Alzheimer’s disease (AD), exhibiting tau pathology and synaptic dysfunction. Cornel iridoid glycoside (CIG) is an active ingredient extracted from Cornus officinalis , a traditiona…
View article: Abnormal Myocardial Enzymes are Important Indicators of Poor Prognosis in COVID-19 Patients
Abnormal Myocardial Enzymes are Important Indicators of Poor Prognosis in COVID-19 Patients Open
Objective: Researching the prognostic value of myocardial enzymes in COVID-19 patients. Materials & methods: We collected 113 confirmed COVID-19 patients. The dynamic changes of CK, LDH and α-HBDH in patients were studied retrospectively, …
View article: MA06.09 Preliminary Safety, Efficacy Results of KN046 (Bispecific Anti-PD-L1/CTLA4) in Subjects With Rare Thoracic Tumors
MA06.09 Preliminary Safety, Efficacy Results of KN046 (Bispecific Anti-PD-L1/CTLA4) in Subjects With Rare Thoracic Tumors Open
View article: Exogenous γ-glutamic acid (GABA) induces proline and glutathione synthesis in alleviating Cd-induced photosynthetic inhibition and oxidative damage in tobacco leaves
Exogenous γ-glutamic acid (GABA) induces proline and glutathione synthesis in alleviating Cd-induced photosynthetic inhibition and oxidative damage in tobacco leaves Open
The effects of exogenous γ-glutamic acid (GABA) on photosynthetic gas exchange capacity, PSII function, proline (Pro) synthesis and ROS metabolism of tobacco leaves under cadmium (Cd) stress were studied. The results showed that both stoma…
View article: C-Reactive Protein and Lymphocyte are important indicators of severe coronavirus disease and poor prognosis in elderly patients
C-Reactive Protein and Lymphocyte are important indicators of severe coronavirus disease and poor prognosis in elderly patients Open
Objective： To explore the value of C-reactive protein (CRP) and lymphocyte (L) in the assessment of disease severity and prognosis of elderly COVID-19 patients. Methods: A total of 194 positive COVID-19 patients were collected from Tianyou…
View article: C-Reactive Protein and Lymphocyte are important indicators of severe coronavirus disease and poor prognosis in elderly patients
C-Reactive Protein and Lymphocyte are important indicators of severe coronavirus disease and poor prognosis in elderly patients Open
Objective： To explore the value of C-reactive protein (CRP) and lymphocyte (L) in the assessment of disease severity and prognosis of elderly COVID-19 patients. Methods: A total of 194 positive COVID-19 patients were collected from Tianyou…
View article: Physiological and proteomics responses of nitrogen assimilation and glutamine/glutamine family of amino acids metabolism in mulberry (<i>Morus alba</i> L.) leaves to NaCl and NaHCO<sub>3</sub> stress
Physiological and proteomics responses of nitrogen assimilation and glutamine/glutamine family of amino acids metabolism in mulberry (<i>Morus alba</i> L.) leaves to NaCl and NaHCO<sub>3</sub> stress Open
In order to find out the response mechanism of nitrogen assimilation and glutamine/glutamine family of amino acids metabolism in mulberry (Morus alba L.) leaves under NaCl and NaHCO3 stress, and to reveal its role in salt…
View article: C-Reactive Protein and Lymphocyte are important indicators of severe coronavirus disease and poor prognosis in elderly patients
C-Reactive Protein and Lymphocyte are important indicators of severe coronavirus disease and poor prognosis in elderly patients Open
Objective： To explore the value of C-reactive protein (CRP) and lymphocyte (L) in the assessment of disease severity and prognosis of elderly COVID-19 patients. Methods: A total of 194 positive COVID-19 patients were collected from Tianyou…
View article: CRP and L are important indicators of severe coronavirus disease and poor prognosis in elderly patients
CRP and L are important indicators of severe coronavirus disease and poor prognosis in elderly patients Open
Objective：To explore the value of C-reactive protein (CRP) and lymphocyte (L) in the assessment of disease severity and prognosis of elderly COVID-19 patients.Methods: A total of 150 patients with COVID-19 confirmed by positive pathogen nu…
View article: Dehydrocostus lactone inhibits cell proliferation and induces apoptosis by PI3K/Akt/Bad and ERS signalling pathway in human laryngeal carcinoma
Dehydrocostus lactone inhibits cell proliferation and induces apoptosis by PI3K/Akt/Bad and ERS signalling pathway in human laryngeal carcinoma Open
The anti‐cancer effect of dehydrocostus lactone (DHL) derived from Saussurea costus (Falc.) Lipech against laryngeal carcinoma was assessed. The cytotoxic activity of DHL against laryngeal carcinoma is still obscure. Therefore, our study i…
View article: Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells
Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells Open
Germacrone, a natural 10‐membered monocyclic sesquiterpene with three double bonds and a ketone, was isolated from the roots of traditional Chinese medicine Saussurea costus (SC). The pharmacological value and intrinsic mechanism of germac…
View article: FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and inflammation
FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and inflammation Open
View article: Efficient treatment of Parkinson’s disease using ultrasonography-guided rhFGF20 proteoliposomes
Efficient treatment of Parkinson’s disease using ultrasonography-guided rhFGF20 proteoliposomes Open
Fibroblast growth factor-20 (FGF20) is a paracrine member of the FGF family that is preferentially expressed in the substantia nigra pars compacta (SNpc). Previous studies have demonstrated that FGF20 enhances the survival of dopaminergic …