Kun Shao
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View article: An Intelligent Directional Drill Steering Method Based on Real-Time Adaptive Closed-Loop Control
An Intelligent Directional Drill Steering Method Based on Real-Time Adaptive Closed-Loop Control Open
Drilling trajectory closed-loop control in directional drilling is a key technology for achieving high-precision drilling. However, due to the complex geological conditions, and engineering limitations of drilling tools, traditional contro…
View article: Cascaded hollow FP cavities on fiber end-face for ultrasonic and photoacoustic detection
Cascaded hollow FP cavities on fiber end-face for ultrasonic and photoacoustic detection Open
For photoacoustic (PA) detectors, compact form factor, exceptional sensitivity, broad bandwidth, and omnidirectional responsiveness are crucial performance indicators. In this research, we introduce what we believe to be a novel cascaded h…
View article: Cellular and molecular basis of <i>Pf</i>Coronin function in artemisinin resistance in <i>Plasmodium falciparum</i>
Cellular and molecular basis of <i>Pf</i>Coronin function in artemisinin resistance in <i>Plasmodium falciparum</i> Open
Summary Artemisinin-based therapies are central to malaria treatment, but their efficacy is threatened by the emergence of resistant Plasmodium falciparum strains. While the role of Pfkelch13 mutations in clinical resistance is well establ…
View article: Uncertainty-quantified Rollout Policy Adaptation for Unlabelled Cross-domain Temporal Grounding
Uncertainty-quantified Rollout Policy Adaptation for Unlabelled Cross-domain Temporal Grounding Open
Video Temporal Grounding (TG) aims to temporally locate video segments matching a natural language description (a query) in a long video. While Vision-Language Models (VLMs) are effective at holistic semantic matching, they often struggle …
View article: A SOH Estimation Method for Lithium-Ion Batteries Based on CPA and CNN-KAN
A SOH Estimation Method for Lithium-Ion Batteries Based on CPA and CNN-KAN Open
Lithium-ion batteries are the primary power source for new energy vehicles, making accurate estimation of their state of health (SOH) essential for ensuring the safe operation of battery systems. This paper proposes a Capacity–Power Analys…
View article: Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer
Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer Open
Photo‐responsive/activable nanomedicine‐driven therapies have emerged as a transformative approach to effectively target and eliminate tumors across different types of solid cancers. When synergistically combined with immunomodulators, the…
View article: State-of-Health Estimation for Lithium-Ion Batteries via Incremental Energy Analysis and Hybrid Deep Learning Model
State-of-Health Estimation for Lithium-Ion Batteries via Incremental Energy Analysis and Hybrid Deep Learning Model Open
Accurate State-of-Health (SOH) estimation is a key technology for ensuring battery safety, optimizing energy management, and enhancing lifecycle value. This paper proposes a novel SOH estimation method for lithium-ion batteries, utilizing …
View article: Investigation of the relationship between blood lactate levels and neonatal hyperbilirubinemia: A predictive approach to assessing severity on NHB in neonates
Investigation of the relationship between blood lactate levels and neonatal hyperbilirubinemia: A predictive approach to assessing severity on NHB in neonates Open
Background: Neonatal hyperbilirubinemia (NHB) severity is traditionally assessed using serum total bilirubin levels alone; however, bilirubin measurement can be influenced by multiple physiological factors, limiting its accuracy. This stud…
View article: Epigenetic activation of JAG1 by AID contributes to metastasis of hepatocellular carcinoma
Epigenetic activation of JAG1 by AID contributes to metastasis of hepatocellular carcinoma Open
Metastasis is a major cause of fatality in hepatocellular carcinoma (HCC), although the precise mechanisms driving the metastatic process remain incompletely understood. In this study, we have made several important findings. Firstly, we h…
View article: Spatiotemporal Controllable Sono‐Nanovaccines Driven by Free‐Field Based Whole‐Body Ultrasound for Personalized Cancer Therapy
Spatiotemporal Controllable Sono‐Nanovaccines Driven by Free‐Field Based Whole‐Body Ultrasound for Personalized Cancer Therapy Open
Therapeutic cancer vaccines fail to produce satisfactory outcomes against solid tumors since vaccine‐induced anti‐tumor immunity is significantly hampered by immunosuppression. Generating an in situ cancer vaccine targeting immunological c…
View article: Derivation of no significant risk levels for three lower acrylates: Conclusions and recommendations from an expert panel
Derivation of no significant risk levels for three lower acrylates: Conclusions and recommendations from an expert panel Open
View article: Effects of High / Low Oxygen Combined With 1-MCP on The Quality and Volatile Components of Mints During Storage
Effects of High / Low Oxygen Combined With 1-MCP on The Quality and Volatile Components of Mints During Storage Open
To investigate the effect of high / low oxygen combined with 1-methylcyclopropene (1-MCP) on the quality and volatile components of mints during storage, and to analyze the intrinsic relationship between volatile components and peppermint …
View article: Artemisinin resistance mutations in<i>Pfcoronin</i>impede hemoglobin uptake
Artemisinin resistance mutations in<i>Pfcoronin</i>impede hemoglobin uptake Open
Artemisinin (ART) combination therapies have been critical in reducing malaria morbidity and mortality, but these important drugs are threatened by growing resistance associated with mutations in Pfcoronin and Pfkelch13 . Here, we describe…
View article: Biological interactions of polystyrene nanoplastics: Their cytotoxic and immunotoxic effects on the hepatic and enteric systems
Biological interactions of polystyrene nanoplastics: Their cytotoxic and immunotoxic effects on the hepatic and enteric systems Open
As emerging pollutants in the environment, nanoplastics (NPs) can cross biological barriers and be enriched in organisms, posing a greatest threat to the health of livestock and humans. However, the size-dependent toxic effects of NPs in h…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 47/2022
Graphical Abstract: Angew. Chem. Int. Ed. 47/2022 Open
International Edition is a journal of the Gesellschaft Deutscher Chemiker (GDCh), the largest chemistryrelated scientific society in continental Europe.Information on the various activities and services of the GDCh, for example, cheaper su…
View article: Novel Water-Soluble Chlorin-Based Photosensitizer for Low-Fluence Photodynamic Therapy
Novel Water-Soluble Chlorin-Based Photosensitizer for Low-Fluence Photodynamic Therapy Open
Photodynamic therapy (PDT), performed with low-fluence rates, can improve antitumor responses and prevent adverse effects. However, photosensitizers (PSs) for low-fluence PDT treatment are rarely reported. Herein, we exploited an amphiphil…
View article: Biological Interactions of Polystyrene Nanoplastics: Their Cytotoxic and Immunotoxic Effects on the Hepatic and Enteric Systems
Biological Interactions of Polystyrene Nanoplastics: Their Cytotoxic and Immunotoxic Effects on the Hepatic and Enteric Systems Open
View article: 7,8-Dihydroxyflavone alleviates apoptosis and inflammation induced by retinal ischemia-reperfusion injury via activating TrkB/Akt/NF-kB signaling pathway
7,8-Dihydroxyflavone alleviates apoptosis and inflammation induced by retinal ischemia-reperfusion injury via activating TrkB/Akt/NF-kB signaling pathway Open
Retinal ischemia-reperfusion injury (RIRI) is of common occurrence in retinal and optic nerve diseases. The BDNF/TrkB signaling pathway has been examined to be neuroprotective in RIRI. In this study, we investigated the role of a potent se…
View article: An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression
An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression Open
The “molecular machine” C34 could suppress tumor systemically via unimolecule-mediated sono/immunotherapy.
View article: Estimation of Spontaneous Transient Dynamics based on Peri-event Data
Estimation of Spontaneous Transient Dynamics based on Peri-event Data Open
View article: Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy
Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy Open
View article: <i>Ex vivo</i> identification of circulating tumor cells in peripheral blood by fluorometric “turn on” aptamer nanoparticles
<i>Ex vivo</i> identification of circulating tumor cells in peripheral blood by fluorometric “turn on” aptamer nanoparticles Open
The detection of the circulating tumor cells (CTCs) detached from solid tumors has emerged as a burgeoning topic for cancer diagnosis and treatment.
View article: A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis
A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis Open
In situ vaccine–based combinatorial therapy induced potent tumor-specific immunity against tumor recurrence and metastasis.
View article: An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging
An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging Open
View article: Ubiquitous antigen-specific T regulatory type 1 cells variably suppress hepatic and extrahepatic autoimmunity
Ubiquitous antigen-specific T regulatory type 1 cells variably suppress hepatic and extrahepatic autoimmunity Open
Peptide MHC class II-based (pMHCII-based) nanomedicines trigger the formation of multicellular regulatory networks by reprogramming autoantigen-experienced CD4+ T cells into autoimmune disease-suppressing T regulatory type 1 (TR1) cells. W…
View article: Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines
Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines Open
View article: Intracellular MicroRNA imaging using telomerase-catalyzed FRET ratioflares with signal amplification
Intracellular MicroRNA imaging using telomerase-catalyzed FRET ratioflares with signal amplification Open
Telomerase participation causes microRNA circulation in a testing system, which reliably enhances the difference between cancer cells and normal cells.
View article: <i>In situ</i> imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe
<i>In situ</i> imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe Open
In this work, a novel NIR two-photon fluorescence probe DCM-APN is reported for tracking APN in vitro and in vivo.
View article: Reply to “The Brain, Amphotericin B, and P-Glycoprotein”
Reply to “The Brain, Amphotericin B, and P-Glycoprotein” Open
We thank David A. Stevens et al. ([1][1]) for [the letter][2] suggesting different results regarding the effect of P-glycoprotein on the brain concentration of amphotericin B (AMB) by P-glycoprotein knockout mice. In contrast to our findin…