Kan Liu
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View article: SV2B Promotes the Progression of TFE3‐Rearranged Renal Cell Carcinoma by Interacting with HERC2 to Impede the Degradation of NF‐κB Subunits
SV2B Promotes the Progression of TFE3‐Rearranged Renal Cell Carcinoma by Interacting with HERC2 to Impede the Degradation of NF‐κB Subunits Open
TFE3‐rearranged renal cell carcinoma (TFE3‐RCC) represents an aggressive subtype of renal cancer characterized by a poor prognosis, yet lacking clearly defined diagnostic and therapeutic targets. Here, the study demonstrates that synaptic …
View article: Integrated bioinformatics analysis reveals novel PANoptosis biomarkers and therapeutic response in clear cell renal cell carcinoma
Integrated bioinformatics analysis reveals novel PANoptosis biomarkers and therapeutic response in clear cell renal cell carcinoma Open
Clear cell renal cell carcinoma (ccRCC) is the most common type of RCC. Apoptosis, pyroptosis, and necroptosis are key regulatory processes in carcinogenesis. Accumulating evidence indicated significant crosstalk among three forms of cell …
View article: FAP+ fibroblasts orchestrate tumor microenvironment remodeling in renal cell carcinoma with tumor thrombus
FAP+ fibroblasts orchestrate tumor microenvironment remodeling in renal cell carcinoma with tumor thrombus Open
View article: Deep Neural Network Algorithm Using the Electrocardiogram for Detection of Obstructive Sleep Apnea
Deep Neural Network Algorithm Using the Electrocardiogram for Detection of Obstructive Sleep Apnea Open
Our AI-ECG model demonstrated good diagnostic performance as an ECG-based screening tool for OSA in a clinical population, particularly among females. Incorporating this algorithm in medical practice may enable widespread low-cost screenin…
View article: Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine
Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine Open
Aggregation‐induced emission (AIE) has emerged as a powerful tool for the design of next‐generation intelligent theranostic systems. AIE luminogens (AIEgens) exhibit exceptional sensitivity and signal fidelity in complex biological environ…
View article: Author Correction: hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p
Author Correction: hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p Open
View article: Coronary vasodilator capacity in obesity and morbid obesity – divergent flow responses with left ventricular hypertrophy
Coronary vasodilator capacity in obesity and morbid obesity – divergent flow responses with left ventricular hypertrophy Open
View article: HEP14-activated PKC-ERK1/2 pathway boosts HEP14-empowered hADSCs for ovarian regeneration and functional restoration
HEP14-activated PKC-ERK1/2 pathway boosts HEP14-empowered hADSCs for ovarian regeneration and functional restoration Open
Premature ovarian insufficiency (POI) and age-related natural-aging ovarian insufficiency (ARNA-OI) pose pressing global health challenges, necessitating effective therapeutic strategies and a deep understanding of their underlying mechani…
View article: Cross-cohort microbiome-wide study reveals consistent alterations in the gut bacteriome, but not the gut mycobiome, in patients with hypertension
Cross-cohort microbiome-wide study reveals consistent alterations in the gut bacteriome, but not the gut mycobiome, in patients with hypertension Open
Hypertension, one of the most prevalent cardiovascular diseases, has been linked to the gut microbiota. However, there is a lack of well-defined, cross-population validated gut microbial signatures associated with hypertension, particularl…
View article: HEP14 treatment improves ovarian function in aged mice through mitophagy enhancement and oxidative stress reduction
HEP14 treatment improves ovarian function in aged mice through mitophagy enhancement and oxidative stress reduction Open
View article: Systematic pan-cancer analysis identifies PKNOX1 as a potential prognostic and immunological biomarker and its functional validation
Systematic pan-cancer analysis identifies PKNOX1 as a potential prognostic and immunological biomarker and its functional validation Open
Background PBX/knotted1 homeobox 1 (PKNOX1), also known as PREP1, is a homeodomain transcription factor that has been reported to be involved in the progression of gastric adenocarcinoma and non-small cell lung cancer. However, its express…
View article: Comparison of clinical features and outcomes of Chinese patients with Takotsubo syndrome and acute myocardial infarction—results from the first Chinese Takotsubo syndrome registry
Comparison of clinical features and outcomes of Chinese patients with Takotsubo syndrome and acute myocardial infarction—results from the first Chinese Takotsubo syndrome registry Open
In comparison to AMI patients, Chinese TTS patients developed more in-hospital complications and had a worse short-term prognosis. The cardiovascular issues in TTS patients underscore the need for effective treatment and personalized strat…
View article: A phase I dose-escalation and dose-expansion study of tibremciclib, a novel CDK4/6 inhibitor, monotherapy and in combination with fulvestrant in HR-positive/HER2-negative advanced breast cancer
A phase I dose-escalation and dose-expansion study of tibremciclib, a novel CDK4/6 inhibitor, monotherapy and in combination with fulvestrant in HR-positive/HER2-negative advanced breast cancer Open
View article: GAMT facilitates tumor progression via inhibiting p53 in clear cell renal cell carcinoma
GAMT facilitates tumor progression via inhibiting p53 in clear cell renal cell carcinoma Open
View article: Characterization and Identification of the Chemical Constituents and the Metabolites of <i>Geum japonicum</i> Thunb. var. <i>chinense</i> F. Bolle
Characterization and Identification of the Chemical Constituents and the Metabolites of <i>Geum japonicum</i> Thunb. var. <i>chinense</i> F. Bolle Open
Introduction Geum japonicum Thunb. var. chinense F. Bolle (GJ) holds significance as a traditional Miao medicine, one of China's ethnic minorities, extensively utilized in the clinical management of cardiovascular ailments. However, little…
View article: Enhanced intragranular precipitation strengthening in Sc-microalloyed ultrafine-grained SiCp/Al-Cu-Mg composites via retrogression and re-ageing heat treatment
Enhanced intragranular precipitation strengthening in Sc-microalloyed ultrafine-grained SiCp/Al-Cu-Mg composites via retrogression and re-ageing heat treatment Open
Ultrafine-grained Al matrix composites suffer from the insufficient dislocation accumulation capability and intragranular precipitation strengthening due to their length-scale dependent precipitation behaviors. In this work, a combination …
View article: Maternal exposure to polystyrene nanoplastics induces sex-specific kidney injury in offspring
Maternal exposure to polystyrene nanoplastics induces sex-specific kidney injury in offspring Open
Maternal exposure to polystyrene nanoplastics (PS-NPs) during pregnancy and lactation has been linked to adverse effects on offspring kidney development, with sex-specific outcomes. This study investigated the impact of maternal PS-NPs exp…
View article: Slot‐Die Coating of Ammonium Salt Passivation Layer for High‐Performance Perovskite Solar Cells and Modules
Slot‐Die Coating of Ammonium Salt Passivation Layer for High‐Performance Perovskite Solar Cells and Modules Open
Scaling up high‐performance perovskite solar cells (PSCs) while avoiding losses in the power conversion efficiency (PCE) is a challenging task. Surface passivation of the perovskite film has been demonstrated as an effective strategy to mi…
View article: Proliferation and migration inhibition of adenoid cystic carcinoma cells through autophagy suppression via GLUT1 knockdown
Proliferation and migration inhibition of adenoid cystic carcinoma cells through autophagy suppression via GLUT1 knockdown Open
Multiple studies have demonstrated a significant association between glucose transporter-1 (GLUT1) and the development and recurrence of adenoid cystic carcinoma (ACC). In this study, we investigated the impact of GLUT1 knockdown on adenoi…
View article: Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications
Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications Open
Our study aims to investigate the role of pyrimidine metabolism in prostate cancer and its associations with the immune microenvironment, drug sensitivity, and tumor mutation burden. Through transcriptomic and single-cell RNA sequencing an…
View article: hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p
hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p Open
Circular RNAs (circRNAs) are widely involved in diverse biological processes of cancers. Nonetheless, the potential function of hsa_circ_0008305 in hepatocellular carcinoma (HCC) remains largely unknown. This study aims to elucidate the ro…
View article: Combined BRAF G469A mutation and echinoderm microtubule associated protein like-4-anaplastic lymphoma kinase rearrangement with resistance: A case report and review of literature
Combined BRAF G469A mutation and echinoderm microtubule associated protein like-4-anaplastic lymphoma kinase rearrangement with resistance: A case report and review of literature Open
BACKGROUND Through deeper understanding of targetable driver mutations in non-small-cell lung cancer (NSCLC) over the past years, some patients with driver mutations have benefited from the targeted molecular therapies. Although the anapla…
View article: Deep learning method for detecting fluorescence spots in cancer diagnostics via fluorescence in situ hybridization
Deep learning method for detecting fluorescence spots in cancer diagnostics via fluorescence in situ hybridization Open
View article: Noninvasive Positive Pressure Ventilation versus High-Flow Nasal Cannula for Chronic Obstructive Pulmonary Disease: An Updated Narrative Review
Noninvasive Positive Pressure Ventilation versus High-Flow Nasal Cannula for Chronic Obstructive Pulmonary Disease: An Updated Narrative Review Open
Chronic obstructive pulmonary disease (COPD) is one of the most common clinical respiratory illnesses, defined by permanent pathological deterioration that leads to respiratory failure. Regarding COPD treatment, oxygen therapy is very impo…
View article: Maternal exposure to polystyrene nanoplastics induces sex-specific cardiotoxicity in offspring mice
Maternal exposure to polystyrene nanoplastics induces sex-specific cardiotoxicity in offspring mice Open
View article: Enhanced strength–ductility synergy of SiC particles reinforced aluminum matrix composite via dual configuration design of reinforcement and matrix
Enhanced strength–ductility synergy of SiC particles reinforced aluminum matrix composite via dual configuration design of reinforcement and matrix Open
To overcome the strength-ductility conflict in particle reinforced aluminum matrix composites (PRAMCs), a novel dual configuration strategy of microstructure was proposed in this work. The dual configuration including both heterogeneous gr…
View article: SwiftDiffusion: Efficient Diffusion Model Serving with Add-on Modules
SwiftDiffusion: Efficient Diffusion Model Serving with Add-on Modules Open
Text-to-image (T2I) generation using diffusion models has become a blockbuster service in today's AI cloud. A production T2I service typically involves a serving workflow where a base diffusion model is augmented with various "add-on" modu…
View article: Serum activin A as a prognostic biomarker for community acquired pneumonia
Serum activin A as a prognostic biomarker for community acquired pneumonia Open
BACKGROUND It is essential to develop new biomarker with effective prognostic roles because of the unclear clinical use of the current community-acquired pneumonia (CAP) predictors. AIM To evaluate the association between serum activin A l…
View article: In-Hospital Adverse Events of Pheochromocytoma-Induced Takotsubo Syndrome: A Literature Review and Cluster Analysis of 172 Cases
In-Hospital Adverse Events of Pheochromocytoma-Induced Takotsubo Syndrome: A Literature Review and Cluster Analysis of 172 Cases Open
Background: Pheochromocytoma-induced takotsubo syndrome (Pheo-TTS) significantly increases the risk of adverse events for inpatient. The early identification of risk factors at admission is crucial for effective risk stratification and min…
View article: Electrocardiogram Signal Analysis With a Machine Learning Model Predicts the Presence of Pulmonary Embolism With Accuracy Dependent on Embolism Burden
Electrocardiogram Signal Analysis With a Machine Learning Model Predicts the Presence of Pulmonary Embolism With Accuracy Dependent on Embolism Burden Open