Explanipedia

Retrospective analysis of ruxolitinib as induction treatment in pediatric hemophagocytic lymphohistiocytosis Open

Shu-yi Guo, Junyan Han, Kun‐yin Qiu, Jian Wang, Jianpei Fang , et al. · 2025

Purpose: To retrospectively evaluate the efficacy and safety of ruxolitinib, with or without intensive chemotherapy, in pediatric patients with hemophagocytic syndrome.Methods: Pediatric patients with newly diagnosed hemophag…

Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up Open

Xuewei Li, Wenhui Zhang, Saisai Li, Xiaolin Ma, Xue Shi , et al. · 2025

Background Hematopoietic stem cell transplantation (HSCT) offers a potentially curative option for severe aplastic anemia (SAA). However, graft failure (GF) remains a life-threatening complication following HSCT. Haploidentical HSCT may se…

Performance of MRI-based radiomics for prediction of residual disease status in patients with nasopharyngeal carcinoma after radical radiotherapy Open

Wu Qinqin, Weiguang Qiang, Liang Pan, T Cha, Qilin Li , et al. · 2025

The purpose of this study was to determine if habitat radiomic features extracted from pretherapy multi-sequence MRI predict residual status in patients with Nasopharyngeal Carcinoma (NPC) after radical radiotherapy. The retrospective stud…

Predictive Model of Gemtuzumab Ozogamicin Response in Childhood Acute Myeloid Leukemia on Event-Free Survival: Data Analysis Based on Trial AAML0531 Open

Kun‐yin Qiu, Xiong‐yu Liao, Jian‐Pei Fang, Dun‐hua Zhou · 2025

Purpose: We aimed to develop a simple nomogram and online calculator that can identify the optimal subpopulation of pediatric acute myeloid leukemia (AML) patients who would benefit most from gemtuzumab ozogamicin (GO) therapy. Methods: Wi…

TARGET based m6A methylation-related genes predict prognosis relapsed B-cell acute lymphoblastic leukemia Open

Kun‐yin Qiu, Xiong‐yu Liao, Jian‐Pei Fang, Dun‐hua Zhou · 2024

TARGET Based m 6 A Methylation-Related Genes Predict Prognosis Relapsed B-cell Acute Lymphoblastic Leukemia Open

Kun‐yin Qiu, Xiong‐yu Liao, Jian‐Pei Fang, Dun‐hua Zhou · 2024

Purpose The current study aim to investigate the significance of N6-methyladenosine (m⁶A) methylationrelated genes in the clinical prognosis of childhood relapsed B-cell acute lymphoblastic leukemia patient. Methods Transcriptom…

Benefits of the Continuous Use of 6-MP/MTX with Pulses of VCR/DEX in Maintenance Therapy for Pediatric Acute Lymphoblastic Leukemia: A Report from South China Children's Leukemia Group Open

Kun‐yin Qiu, Libin Huang, Huirong Mai, Xinyu Li, Yan‐Lai Tang , et al. · 2024

Coexistence of ETV6-RUNX1 and MLL aberration among pediatric acute lymphoblastic leukemia: case reports and a literature review Open

Kun‐yin Qiu, Xiong‐yu Liao, Ke Huang, Hong‐Gui Xu, Li Yang , et al. · 2023

The results of our analysis primarily provide compelling evidence that cases with an MLL-PTD or other types of MLL aberration are in fact a distinct subentry among ETV6-RUNX1 B-cell ALL (B-ALL).

Real-World Presentation and Prognostic Effect of Allogeneic Blood Transfusion during the Intensive Induction Phase in Pediatric Acute Lymphoblastic Leukemia Open

Kun‐yin Qiu, Xiong‐yu Liao, Yang Li, Ke Huang, Hong‐Gui Xu , et al. · 2023

Purpose: To determine associations between allogeneic blood transfusion (ABT) during the intensive induction phase of therapy and prognostic effect in a real-world cohort of pediatric patients with acute lymphoblastic leukemia (ALL). Metho…

Ruxolitinib inhibits the proliferation and induces the apoptosis of MLL-r ALL cells through inactivating JAK/STAT signaling pathway Open

Xiong‐yu Liao, Dun‐hua Zhou, Jian‐Pei Fang, Kun‐yin Qiu · 2023

These data provide compelling evidence that ruxolitinib is a promising agent against MLL-r leukemia cell line. However, it needs going through multiple more steps to confirm before it can be an option in clinical practice.

Outcome and prognostic factors of CBF pediatric AML patients with t(8;21) differ from patients with inv(16) Open

Kun‐yin Qiu, Xiong‐yu Liao, Yang Li, Ke Huang, Hong-Gui Xu , et al. · 2023

Purpose To explore the outcome and prognostic factors between inv(16) and t(8;21) disrupt core binding factor (CBF) in acute myeloid leukemia (AML). Methods The clinical characteristic, probability of achieving complete remission (CR), ove…

Real World Presentation and Prognostic Effect of Allogeneic Blood Transfusion During the Intensive Induction Phase Among Pediatric Acute Lymphoblastic Leukemia Open

Kun‐yin Qiu, Xiong‐yu Liao, Yang Li, Ke Huang, Hong-Gui Xu , et al. · 2023

TARGET Based m6A Methylation-Related Genes Predict Prognosis Relapsed B-Cell Acute Lymphoblastic Leukemia Open

Kun‐yin Qiu, Xiong‐yu Liao, Jian‐Pei Fang, Dun‐hua Zhou · 2023

Benefits of the Continuous Use of 6-MP/MTX with Pulses of VCR/DEX in Maintenance Therapy for Pediatric Acute Lymphoblastic Leukemia: A Report from South China Children's Leukemia Group Open

Kun‐yin Qiu, Libin Huang, Huirong Mai, Xinyu Li, Yan‐Lai Tang , et al. · 2023

Prognostic value and outcome for acute lymphocytic leukemia in children with MLL rearrangement: a case-control study Open

Kun‐yin Qiu, Dun‐hua Zhou, Xiong‐yu Liao, Ke Huang, Yang Li , et al. · 2022

Purpose To evaluate the prognostic factors and outcome for acute lymphoblastic leukemia (ALL) in children with MLL rearrangement (MLL-r). Methods A total of 124 pediatric patients who were diagnosed with ALL were classified into two groups…

Analysis of clinical characteristics and prognostic factors associated with EBV-associated HLH in children Open

Kun‐yin Qiu, Shu-yi Guo, Yang-hui Zeng, Xiong‐yu Liao, Shaofen Lin , et al. · 2022

Purpose Our aim is to analyze the clinical characteristics and prognostic factors of Epstein-Barr (EB) virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) in children. Methods Children with newly diagnosed HLH were retrospectivel…

Umbilical cord blood: A promising source for allogeneic CAR-T cells Open

Dian-Dian Liu, Weicong Hong, Kun‐yin Qiu, Xinyu Li, Yong Liu , et al. · 2022

Chimeric antigen receptor T (CAR-T) cell therapy is an effective treatment for relapsed and refractory acute lymphoblastic leukemia (R/R ALL). However, autologous CAR-T cells derived from patients with B-ALL often show poor amplification a…

Poor outcome of pediatric patients with acute myeloid leukemia harboring high FLT3/ITD allelic ratios Open

Kun‐yin Qiu, Xiong‐yu Liao, Yong Liu, Ke Huang, Yang Li , et al. · 2022

Poor Outcome of Pediatric Patients with Acute Myeloid Leukemia Harboring High FLT3/ITD Allelic Ratios Open

Kun‐yin Qiu · 2022

Source data of "Poor Outcome of Pediatric Patients with Acute Myeloid Leukemia Harboring High FLT3/ITD Allelic Ratios"

Prognostic Value and Outcome for ETV6/RUNX1-Positive Pediatric Acute Lymphoblastic Leukemia: A Report From the South China Children’s Leukemia Group Open

Kun‐yin Qiu, Hong-Gui Xu, Xue‐Qun Luo, Huirong Mai, Ning Liao , et al. · 2021

Purpose To analyzed the outcome of ETV6/RUNX1-positive pediatric acute B lymphoblastic leukemia (B-ALL) with the aim of identifying prognostic value. Method A total of 2,530 pediatric patients who were diagnosed with B-ALL were classified …

An Integrative Pan-Cancer Analysis of the Prognostic and Immunological Role of Casein Kinase 2 Alpha Protein 1 (CSNK2A1) in Human Cancers: AStudy Based on Bioinformatics and Immunohistochemical Analysis Open

Ruohao Wu, Wenting Tang, Kun‐yin Qiu, Pinggan Li, Yu Li , et al. · 2021

These findings suggested that CSNK2A1 was not only related to poor clinical prognosis in cancer like LIHC but also a novel immunotherapy-related biomarker in cancers, especially in LIHC, shedding new light on anti-tumor strategy.

DNA index as prognostic factor in childhood acute lymphoblastic leukemia in the COG-TARGET database Open

Kun‐yin Qiu, Xiong‐yu Liao, Zhanwen He, Ruohao Wu, Yang Li , et al. · 2021

Background This study was aimed to evaluate the value of DNA index(DI) among pediatric acute lymphoblastic leukemia (ALL) treated on Children’s Oncology Group (COG) protocols between 2000 and 2015. Methods Retrospective study were analysis…

Identification of novel <i>CSNK2A1</i> variants and the genotype–phenotype relationship in patients with Okur–Chung neurodevelopmental syndrome: a case report and systematic literature review Open

Ruohao Wu, Wenting Tang, Kun‐yin Qiu, Xiaojuan Li, Danxia Tang , et al. · 2021

De novo germline variants of the casein kinase 2α subunit (CK2α) gene ( CSNK2A1) have been reported in individuals with the congenital neuropsychiatric disorder Okur–Chung neurodevelopmental syndrome (OCNS). Here, we report on two unrelate…

Re-Evaluate of DNA Index Among the Childhood Acute Lymphoblastic Leukemia Open

Kun‐yin Qiu, Xiong‐yu Liao, Dun‐hua Zhou, Jian‐Pei Fang · 2021

Background This study was aimed to re-evaluate the value of DNA index(DI) among pediatric acute lymphoblastic leukemia (ALL) with the recent chemotherapy protocols. Methods Retrospective study were analysis among pediatric ALL patients fro…

The Value of Alveolar Lavage Fluid mNGS in the Peripheral Pulmonary Among Children Open

Kun‐yin Qiu, Xiong‐yu Liao, Jian‐Pei Fang, Dun‐hua Zhou · 2021

Objectives The aim of this study was to evaluate the value of alveolar lavage fluid mNGS in the diagnosis of peripheral pulmonary infectious lesions among children.Methods Twenty-eight consecutive pediatric patients suspected of pulmonary …

The Value of Alveolar Lavage Fluid mNGS in The Peripheral Pulmonary Among Children Open

Kun‐yin Qiu, Xiong‐yu Liao, Jian‐Pei Fang, Dun‐hua Zhou · 2021

Objectives The aim of this study was to evaluate the value of alveolar lavage fluid mNGS in the diagnosis of peripheral pulmonary infectious lesions among children. Methods Twenty-eight consecutive pediatric patients suspected of pulmonary…

Poor Outcome of Pediatric Patients with Acute Myeloid Leukemia Harbour High FLT3/ITD Allelic Ratios Open

Kun‐yin Qiu, Xiong‐yu Liao, Dun‐hua Zhou, Jian‐Pei Fang · 2021

Eltrombopag as first‐line treatment for thrombocytopenia among paediatric patients after allogeneic haematopoietic stem cell transplantation Open

Kun‐yin Qiu, Xiong‐yu Liao, Ke Huang, Ruohao Wu, Hong-Gui Xu , et al. · 2020

Aims The purpose of this study is to examine the safety and efficacy of eltrombopag as first‐line treatment for thrombocytopenia among paediatric patients after haematopoietic stem cell transplantation (HSCT). Methods Forty‐three childhood…

Diagnosis and treatment of juvenile myelomonocytic leukemia Open

Xiong‐yu Liao, Kun‐yin Qiu, Jian‐Pei Fang, Ruohao Wu, Shu-yi Guo , et al. · 2019

Objective: To investigate clinical features, diagnosis, treatment strategies and prognosis of juvenile myelomonocytic leukemia (JMML). Methods: The clinical data of 21 patients with JMML who were diagnosed in our hospital fro…

Atrial septal defect in a patient with congenital disorder of glycosylation type 1a: a case report Open

Ruohao Wu, Dongfang Li, Wenting Tang, Kun‐yin Qiu, Li Yu , et al. · 2018

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