Kai Liu
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View article: Bidirectional regulation of lipid metabolism and the tumor microenvironment: new perspectives from mechanism to therapy
Bidirectional regulation of lipid metabolism and the tumor microenvironment: new perspectives from mechanism to therapy Open
The role of lipid metabolism in cancer and immune regulation has received significant attention in recent years. Reprogramming of lipid metabolism is one of the key hallmarks of cancer and plays a critical role in cancer progression by sup…
View article: Genome-wide analysis of terpene synthase family in peanut (Arachis hypogaea L.) explores the potential cross-talk in terpenoid biosynthesis
Genome-wide analysis of terpene synthase family in peanut (Arachis hypogaea L.) explores the potential cross-talk in terpenoid biosynthesis Open
View article: Physicochemical properties of three Yunnan cigar tobacco leaves and identification of aroma compounds in tobacco smoke
Physicochemical properties of three Yunnan cigar tobacco leaves and identification of aroma compounds in tobacco smoke Open
Introduction This study focused on three kinds of cigar tobacco leaves (Yunxue 6, Yunxue 36, Yunxue 2) produced in Yunnan region, and through the systematic analysis of their physicochemical properties and aroma components of the smoke, th…
View article: Three‐Channel Electron Engineered Fe‐88A@CeO <sub>2</sub> /CDs Nanozyme with Enhanced Oxidase‐Like Activity for Efficient Biomimetic Catalysis
Three‐Channel Electron Engineered Fe‐88A@CeO <sub>2</sub> /CDs Nanozyme with Enhanced Oxidase‐Like Activity for Efficient Biomimetic Catalysis Open
Iron‐based metal‐organic framework (MOF) nanozymes have garnered considerable attention owing to a large specific surface area, adjustable porosity, large Fe‐O clusters, and unsaturated Fe sites. However, the sluggish charge‐transfer rate …
View article: Ibrutinib inhibits the replication of multiple poxviruses by targeting the Bruton tyrosine kinase
Ibrutinib inhibits the replication of multiple poxviruses by targeting the Bruton tyrosine kinase Open
The recent surge in global monkeypox (mpox) outbreaks highlights the critical need for developing antiviral agents targeting orthopoxvirus infections. Ibrutinib, a selective Bruton tyrosine kinase (BTK) inhibitor initially approved by the …
View article: Antibody immunogenicity prediction and optimization with ImmunoSeq
Antibody immunogenicity prediction and optimization with ImmunoSeq Open
Therapeutic antibody development faces persistent immunogenicity challenges from anti-drug antibodies (ADA). Identifying peptide fragments presented by major histocompatibility complex is the central challenge in predicting immunogenicity.…
View article: Shenling Tongqiao powder targets TGF-β1/Smad-Wnt/β-catenin axis to suppress epithelial-mesenchymal transition in chronic rhinosinusitis
Shenling Tongqiao powder targets TGF-β1/Smad-Wnt/β-catenin axis to suppress epithelial-mesenchymal transition in chronic rhinosinusitis Open
Our integrated approaches firstly documented EMT dysregulation by multiple makers in CRSsNP patients, and provided novel insights into SLTQP's anti-EMT effects through dual pathway modulation, supporting its application as a complementary …
View article: Machine learning-based prediction model for post-ERCP cholangitis in patients with malignant biliary obstruction: a retrospective multicenter study
Machine learning-based prediction model for post-ERCP cholangitis in patients with malignant biliary obstruction: a retrospective multicenter study Open
View article: Searching for Ideal Electrolytes in the Molecular Universe
Searching for Ideal Electrolytes in the Molecular Universe Open
"Advanced batteries such as lithium-ion batteries (LIB) based on graphitic carbon or silicon as the anode, as well as lithium-metal batteries (LMB), are complicated systems consisting of multiple components operating at extreme potentials.…
View article: A Low-Intensity Nutrition Intervention Targeting Triglycerides in Gestational Diabetes: A Feasibility RCT
A Low-Intensity Nutrition Intervention Targeting Triglycerides in Gestational Diabetes: A Feasibility RCT Open
Context The conventional approach to diet therapy for gestational diabetes mellitus (GDM) is carbohydrate modification to mitigate glucose-mediated fetal macrosomia. Maternal triglyceride concentrations more strongly relate to infant adipo…
View article: Association Analysis of SLC11A1 Polymorphisms with Somatic Cell Score in Chinese Holstein Cows
Association Analysis of SLC11A1 Polymorphisms with Somatic Cell Score in Chinese Holstein Cows Open
Mastitis is an important disease limiting milk production in dairy cows. Somatic cell score is commonly used as one of the main ways to gauge the level of mastitis in dairy cows, with higher somatic cell scores usually indicating possible …
View article: What do women know and understand about nutrition for pregnancy? A qualitative analysis
What do women know and understand about nutrition for pregnancy? A qualitative analysis Open
Optimal nutrition supply to the developing foetus is paramount in achieving appropriate foetal growth and development. The Australian dietary guidelines advise about the amounts and types of foods for pregnancy (1) . However, previous stud…
View article: Diaphragm excursion and diaphragm thickening fraction: commonality and conflict
Diaphragm excursion and diaphragm thickening fraction: commonality and conflict Open
Diaphragm excursion (DE) and diaphragm thickening fraction (DTF) are complementary but distinct parameters. There may be conflict between increased DTF with decreased DE and increased DE with decreased DTF in two specific clinical scenario…
View article: A negative correlation of low estimated glucose disposal rate with significant liver fibrosis in adults with NAFLD and obesity: results from NHANES 2017–2020
A negative correlation of low estimated glucose disposal rate with significant liver fibrosis in adults with NAFLD and obesity: results from NHANES 2017–2020 Open
View article: Bayesian methods as a complementary tool: balancing innovation and rigor in critical care research
Bayesian methods as a complementary tool: balancing innovation and rigor in critical care research Open
View article: The clinical features and outcomes of diabetes patients infected with COVID-19: a systematic review and meta-analysis comprising 192,693 patients
The clinical features and outcomes of diabetes patients infected with COVID-19: a systematic review and meta-analysis comprising 192,693 patients Open
Objectives We sought to explore the relevance of analyses that include critical laboratory parameters and drug treatment, clinical characteristics of diabetic patients who are infected with COVID-19, to the development of individualized tr…
View article: Comparative evaluation of high-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) in infants after non-cardiac surgery: Study protocol of a randomized controlled trial
Comparative evaluation of high-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) in infants after non-cardiac surgery: Study protocol of a randomized controlled trial Open
Background Literature regarding the advantages of HFNC in infants for ensuring oxygen supply after non-cardiac surgery is insufficient. The purpose of our study is to compare COT vs. HFNC on postoperative outcomes in infants undergoing non…
View article: Synergic Effects of Curcumin, Licorice, and Endoscopic Photodynamic Therapy Against Helicobacter Pylori by Modulating the NF-Κb Signaling Pathway.
Synergic Effects of Curcumin, Licorice, and Endoscopic Photodynamic Therapy Against Helicobacter Pylori by Modulating the NF-Κb Signaling Pathway. Open
Our results demonstrated that combination treatment of PDT with Curcumin and Licorice may exert stronger anti-inflammatory effects by suppressing NF-κB p65 expression in GECs compared to each treatment alone. This combination could serve a…
View article: Simple, sensitive and specific detection method for polystyrene nanoplastics in food matrix based on peptide-modified Fe3O4@Au magnetic nanoparticles
Simple, sensitive and specific detection method for polystyrene nanoplastics in food matrix based on peptide-modified Fe3O4@Au magnetic nanoparticles Open
View article: Arthroscopic patellar denervation with microfracture for treating patellofemoral arthritis in cold weather conditions: a retrospective clinical analysis
Arthroscopic patellar denervation with microfracture for treating patellofemoral arthritis in cold weather conditions: a retrospective clinical analysis Open
Objective To evaluate the clinical efficacy of combining arthroscopic patellar denervation with microfracture in the treatment of patellofemoral arthritis under cold weather conditions. Methods A total of 134 patients with patellofemoral a…
View article: The assessment of postoperative cholangitis in malignant biliary obstruction: a real-world study of nasobiliary drainage after endoscopic placement of self-expandable metal stent
The assessment of postoperative cholangitis in malignant biliary obstruction: a real-world study of nasobiliary drainage after endoscopic placement of self-expandable metal stent Open
Objectives Endoscopic retrograde cholangiopancreatography(ERCP) with endoscopic metallic biliary endoprosthesis(EMBE) serves as a crucial palliative treatment for advanced malignant biliary obstruction(MBO). While endoscopic nasobiliary dr…
View article: Network pharmacology and experimental study of Angelica sinensis and Astragalus membranaceus capsules in treating heart failure
Network pharmacology and experimental study of Angelica sinensis and Astragalus membranaceus capsules in treating heart failure Open
This study preliminarily reveals that AAC can treat HF through multiple components and multiple targets by using network pharmacology, molecular docking, and experimental validation.
View article: Streptococcus agalactiae isolated from clinical mastitis cases on large dairy farms in north China: phenotype, genotype of antimicrobial resistance and virulence genes
Streptococcus agalactiae isolated from clinical mastitis cases on large dairy farms in north China: phenotype, genotype of antimicrobial resistance and virulence genes Open
Streptococcus agalactiae ( Strep. agalactiae ) is bovine mastitis pathogen and has thus became a matter of concern to dairy farms worldwide in terms of economic loss. The aims of this study were to (a) determine virulence genes, and (b) ch…
View article: PE075 Ten years experience of robot-assisted nephrectomy and venous tumor thrombectomy: Is it reasonable to reconsider Mayo Clinic Classification?
PE075 Ten years experience of robot-assisted nephrectomy and venous tumor thrombectomy: Is it reasonable to reconsider Mayo Clinic Classification? Open
View article: Occurrence of antimicrobial resistance and class 1 integrons in <i>Staphylococcus aureus</i> isolated from bovine mastitis in China
Occurrence of antimicrobial resistance and class 1 integrons in <i>Staphylococcus aureus</i> isolated from bovine mastitis in China Open
Integrons are important genetic elements that allow easy acquisition and dissemination of antimicrobial resistance genes. Studies reporting occurrence of integrons in Staphylococcus aureus ( S. aureus ) isolated from bovine mastitis in lar…
View article: A Synergistic Indole-3-Acetic Acid-Producing Synthetic Bacterial Consortium Benefits Walnut Seedling Growth
A Synergistic Indole-3-Acetic Acid-Producing Synthetic Bacterial Consortium Benefits Walnut Seedling Growth Open
Synthetic microbial communities (SynComs) have been shown to be an ecofriendly alternative for promoting plant growth. However, the mechanisms by which SynCom inoculants drive plant growth promotion in rhizosphere soil are still not fully …
View article: Precision treatment of beta-cell monogenic diabetes: a systematic review
Precision treatment of beta-cell monogenic diabetes: a systematic review Open
View article: Retraction: Hypoxia-inducible factor 1a induces phenotype switch of human aortic vascular smooth muscle cell through PI3K/AKT/AEG-1 signaling
Retraction: Hypoxia-inducible factor 1a induces phenotype switch of human aortic vascular smooth muscle cell through PI3K/AKT/AEG-1 signaling Open
// Kai Liu 1 , Changcun Fang 1 , Yuwen Shen 1 , Zhengqin Liu 1 , Min Zhang 1 , Bingbing Ma 1 and Xinyan Pang 1 1 Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China Correspondence to: X…
View article: Corrigendum: Comparative study of alginate and type I collagen as biomaterials for cartilage stem/progenitor cells to construct tissue-engineered cartilage in vivo
Corrigendum: Comparative study of alginate and type I collagen as biomaterials for cartilage stem/progenitor cells to construct tissue-engineered cartilage in vivo Open
[This corrects the article DOI: 10.3389/fbioe.2022.1057199.].
View article: Development and validation of a nomogram to predict postoperative delirium in older patients after major abdominal surgery: a retrospective case-control study
Development and validation of a nomogram to predict postoperative delirium in older patients after major abdominal surgery: a retrospective case-control study Open
Background Postoperative delirium is a common complication in older patients, with poor long-term outcomes. This study aimed to investigate risk factors and develop a predictive model for postoperative delirium in older patients after majo…