Kaizhong Xue
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View article: The genetic architecture of brainstem structures
The genetic architecture of brainstem structures Open
The brainstem houses numerous nuclei and tracts that serve vital functions. Genome-wide associations with brainstem substructure volumes have been explored in European individuals, yet other ancestries remain under-represented. Here, we co…
View article: Unraveling multi‐scale neuroimaging biomarkers and molecular foundations for schizophrenia: A combined multivariate pattern analysis and transcriptome‐neuroimaging association study
Unraveling multi‐scale neuroimaging biomarkers and molecular foundations for schizophrenia: A combined multivariate pattern analysis and transcriptome‐neuroimaging association study Open
Aims Schizophrenia is characterized by alterations in resting‐state spontaneous brain activity; however, it remains uncertain whether variations at diverse spatial scales are capable of effectively distinguishing patients from healthy cont…
View article: Altered functional connectivity within and between resting-state networks in ulcerative colitis
Altered functional connectivity within and between resting-state networks in ulcerative colitis Open
Background Patients with ulcerative colitis (UC) commonly present with affective disorders such as depression and anxiety, especially during the active phase of the disease. However, the possible neurological mechanisms of these symptoms r…
View article: Voxel-based texture similarity networks reveal individual variability and correlate with biological ontologies
Voxel-based texture similarity networks reveal individual variability and correlate with biological ontologies Open
The human brain is organized as a complex, hierarchical network. However, the structural covariance patterns among brain regions and the underlying biological substrates of such covariance networks remain to be clarified. The present study…
View article: Transcriptional signatures of the whole-brain voxel-wise resting-state functional network centrality alterations in schizophrenia
Transcriptional signatures of the whole-brain voxel-wise resting-state functional network centrality alterations in schizophrenia Open
Neuroimaging studies have revealed that patients with schizophrenia exhibit disrupted resting-state functional connectivity. However, the inconsistent findings across these studies have hindered our comprehensive understanding of the funct…
View article: Gray matter volume abnormalities in vascular cognitive impairment and their association with gene expression profiles
Gray matter volume abnormalities in vascular cognitive impairment and their association with gene expression profiles Open
Background: It has been revealed that brain gray matter volume (GMV) abnormalities are present in patients with vascular cognitive impairment (VCI). However, the GMV alterations that have been uncovered are highly inconsistent, and their c…
View article: Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits
Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits Open
Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain…
View article: Schizophrenia mediating the effect of smoking phenotypes on antisocial behavior: A Mendelian randomization analysis
Schizophrenia mediating the effect of smoking phenotypes on antisocial behavior: A Mendelian randomization analysis Open
Aims Previous studies have indicated that smoking is linked to an increased risk of developing schizophrenia, and that individuals with schizophrenia are more prone to engaging in antisocial behavior. However, the causal effects of smoking…
View article: Identifying the mediating role of socioeconomic status on the relationship between schizophrenia and major depressive disorder: a Mendelian randomisation analysis
Identifying the mediating role of socioeconomic status on the relationship between schizophrenia and major depressive disorder: a Mendelian randomisation analysis Open
Depressive disorder prevalence in patients with schizophrenia has been reported to be 40%. People with low socioeconomic status (SES) are more likely to suffer from schizophrenia and major depressive disorder (MDD). However, the causal rel…
View article: Individual‐level brain morphological similarity networks: Current methodologies and applications
Individual‐level brain morphological similarity networks: Current methodologies and applications Open
Aims The human brain is an extremely complex system in which neurons, clusters of neurons, or regions are connected to form a complex network. With the development of neuroimaging techniques, magnetic resonance imaging (MRI)‐based brain ne…
View article: Genes associated with spontaneous brain activity changes in clinically different patients with major depressive disorder: A transcription‐neuroimaging association study
Genes associated with spontaneous brain activity changes in clinically different patients with major depressive disorder: A transcription‐neuroimaging association study Open
Aims The amplitude of low‐frequency fluctuations (ALFF) of resting‐state functional MRI signals is a reliable neuroimaging measure of spontaneous brain activity. Inconsistent ALFF alterations have been reported in major depressive disorder…
View article: Association between gray matter atrophy, cerebral hypoperfusion, and cognitive impairment in Alzheimer’s disease
Association between gray matter atrophy, cerebral hypoperfusion, and cognitive impairment in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is one of the most severe neurodegenerative diseases leading to dementia in the elderly. Cerebral atrophy and hypoperfusion are two important pathophysiological characteristics. However, it is still unkn…
View article: The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults
The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults Open
These findings improve our understanding of the impact of urbanicity on hippocampus and neurocognitive abilities and will benefit for designing more targeted intervention for neurocognitive improvement.
View article: Disrupted local functional connectivity in schizophrenia: An updated and extended meta-analysis
Disrupted local functional connectivity in schizophrenia: An updated and extended meta-analysis Open
Neuroimaging studies have shown that schizophrenia is associated with disruption of resting-state local functional connectivity. However, these findings vary considerably, which hampers our understanding of the underlying pathophysiologica…
View article: Dynamic Functional Connectivity Alterations and Their Associated Gene Expression Pattern in Autism Spectrum Disorders
Dynamic Functional Connectivity Alterations and Their Associated Gene Expression Pattern in Autism Spectrum Disorders Open
Autism spectrum disorders (ASDs) are a group of heterogeneous neurodevelopmental disorders that are highly heritable and are associated with impaired dynamic functional connectivity (DFC). However, the molecular mechanisms behind DFC alter…
View article: Data for "Disrupted localized functional connectivity in schizophrenia: an updated and extended meta-analysis"
Data for "Disrupted localized functional connectivity in schizophrenia: an updated and extended meta-analysis" Open
Neuroimaging studies have shown that schizophrenia is associated with disruption of localized resting-state functional connectivity. However, the results vary considerably, which hamper our understanding of underlying pathophysiological me…
View article: Data for "Disrupted local functional connectivity in schizophrenia: an updated and extended meta-analysis"
Data for "Disrupted local functional connectivity in schizophrenia: an updated and extended meta-analysis" Open
Neuroimaging studies have shown that schizophrenia is associated with disruption of resting-state local functional connectivity. However, these findings vary considerably, which hampers our understanding of the underlying pathophysiologica…
View article: Gene Expression Associated with Human Brain Activations in Facial Expression Recognition
Gene Expression Associated with Human Brain Activations in Facial Expression Recognition Open
Previous studies identified some genetic loci of emotion, but few focused on human emotion-related gene expression. In this study, the facial expression recognition (FER) task-based high-resolution fMRI data of 203 subjects in the Human Co…
View article: Cover Image
Cover Image Open
COVER ILLUSTRATION The molecular mechanisms associated with functional network centrality of human brain are still largely unknown. Zhu et al. calculated functional connectivity strength (FCS), also known as the “degree centrality” of weig…
View article: Correlation between cortical gene expression and resting‐state functional network centrality in healthy young adults
Correlation between cortical gene expression and resting‐state functional network centrality in healthy young adults Open
Resting‐state functional connectivity in the human brain is heritable, and previous studies have investigated the genetic basis underlying functional connectivity. However, at present, the molecular mechanisms associated with functional ne…
View article: Brain mRNA Expression Associated with Cortical Volume Alterations in Autism Spectrum Disorder
Brain mRNA Expression Associated with Cortical Volume Alterations in Autism Spectrum Disorder Open
Numerous studies report abnormal cerebral cortex volume (CCV) in autism spectrum disorder (ASD); however, genes related to CCV abnormalities in ASD remain largely unknown. Here, we identify genes associated with CCV alterations in ASD by p…