Kaja Z. LeWinn
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View article: Examining the impact of child atopic dermatitis on maternal depression: A longitudinal cohort study
Examining the impact of child atopic dermatitis on maternal depression: A longitudinal cohort study Open
Child AD was associated with higher maternal depression scores, especially during early childhood for mothers of children from disadvantaged backgrounds with more severe AD.
View article: The Placental Transcriptome Serves as a Mechanistic Link between Prenatal Phthalate Exposure and Placental Efficiency
The Placental Transcriptome Serves as a Mechanistic Link between Prenatal Phthalate Exposure and Placental Efficiency Open
Prenatal exposure to phthalates, pervasive endocrine-disrupting chemicals, has been linked to child health outcomes, including prematurity and low birthweight. Placental transcriptomics data can reveal mechanisms by which environmental tox…
View article: Air pollution exposures and adverse childhood experiences in relation to sleep health in middle childhood
Air pollution exposures and adverse childhood experiences in relation to sleep health in middle childhood Open
View article: Prenatal exposure to phthalates and alternative plasticizers and emotional and behavioral outcomes in early childhood in the Environmental influences on Child Health outcomes (ECHO) cohort
Prenatal exposure to phthalates and alternative plasticizers and emotional and behavioral outcomes in early childhood in the Environmental influences on Child Health outcomes (ECHO) cohort Open
This large-scale study suggests that prenatal exposure to several phthalates, but not to the alternative plasticizer DINCH, may be associated with a small-to-modest increase in externalizing behaviors in young children.
View article: Maternal prenatal carotenoids and child lung function: exploration of modifying factors
Maternal prenatal carotenoids and child lung function: exploration of modifying factors Open
Background While childhood airway outcomes have been associated with prenatal nutrition, few studies examined carotenoids, a group of nutrients with antioxidant properties, as potential modifiers. Objectives In n=677 mother–child dyads enr…
View article: Prenatal Air Pollution Exposure and Autism Spectrum Disorder in the ECHO Consortium
Prenatal Air Pollution Exposure and Autism Spectrum Disorder in the ECHO Consortium Open
Associations with ASD outcomes were present even at low levels of air pollutants. https://doi.org/10.1289/EHP16675.
View article: Early-Life Factors and Body Mass Index Trajectories Among Children in the ECHO Cohort
Early-Life Factors and Body Mass Index Trajectories Among Children in the ECHO Cohort Open
Importance Identifying atypical body mass index (BMI) trajectories in children and understanding associated, modifiable early-life factors may help prevent childhood obesity. Objective To characterize multiphase BMI trajectories in childre…
View article: 0177 Air Pollution and Psychosocial Stress Exposures in Relation to Sleep Health in Middle Childhood
0177 Air Pollution and Psychosocial Stress Exposures in Relation to Sleep Health in Middle Childhood Open
Introduction Prior studies raise concern for air pollution and psychosocial stressors as potential independent risk factors of poor sleep health in children. Chemical-by-non-chemical stress interaction frameworks further suggest that joint…
View article: Early-Life Ozone Exposure and Asthma and Wheeze in Children
Early-Life Ozone Exposure and Asthma and Wheeze in Children Open
Importance Ozone (O 3 ) is the most frequently exceeded air pollutant standard in the US. While short-term exposure is associated with acute respiratory health, the epidemiologic evidence linking postnatal O 3 exposure to childhood asthma …
View article: An assessment of organophosphate ester mixtures and the placental transcriptome
An assessment of organophosphate ester mixtures and the placental transcriptome Open
Prenatal exposure to organophosphate ester (OPE) chemicals, commonly used as flame retardants and plasticizers, has been associated with adverse birth outcomes. The placenta is a critical fetal organ and therefore may be involved in pathog…
View article: Associations of placental lncRNA expression with maternal pre-pregnancy BMI and infant birthweight in two birth cohorts
Associations of placental lncRNA expression with maternal pre-pregnancy BMI and infant birthweight in two birth cohorts Open
Pre-pregnancy obesity (ppOB) is linked to pregnancy complications and abnormal fetal growth through placental mechanisms, and long non-coding RNAs (lncRNAs) may play an epigenetic role in these processes. We investigated overall and sex-sp…
View article: Prenatal exposure to ambient fine particulate matter and child lung function in the CANDLE cohort
Prenatal exposure to ambient fine particulate matter and child lung function in the CANDLE cohort Open
We did not find strong evidence of associations between prenatal ambient PM2.5 exposure and child lung function in a large, well-characterized study sample. However, there was a suggested adverse association between FEV1 and exp…
View article: Associations Between Prenatal Vitamin D and Placental Gene Expression
Associations Between Prenatal Vitamin D and Placental Gene Expression Open
View article: A longitudinal path model examining the transactional nature of parenting and child externalizing behaviors in a large, sociodemographically diverse sample.
A longitudinal path model examining the transactional nature of parenting and child externalizing behaviors in a large, sociodemographically diverse sample. Open
Children's externalizing behaviors are associated with impairments across the lifespan. Developmental psychopathology theories propose transactional (bidirectional) associations between child externalizing behaviors and parenting during ch…
View article: A longitudinal path model examining the transactional nature of parenting and child externalizing behaviors in a large, sociodemographically diverse sample
A longitudinal path model examining the transactional nature of parenting and child externalizing behaviors in a large, sociodemographically diverse sample Open
Children’s externalizing behaviors are associated with impairments across the lifespan. Developmental psychopathology theories propose transactional (bidirectional) associations between child externalizing behaviors and parenting during ch…
View article: Do small effects matter more in vulnerable populations? an investigation using Environmental influences on Child Health Outcomes (ECHO) cohorts
Do small effects matter more in vulnerable populations? an investigation using Environmental influences on Child Health Outcomes (ECHO) cohorts Open
Vulnerable sub-populations with greater baseline percentages at high risk fare worse when exposed to a small insult compared to the general population. This illustrates another facet of health disparity in vulnerable individuals.
View article: Correction: Associations of residential green space with internalizing and externalizing behavior in early childhood
Correction: Associations of residential green space with internalizing and externalizing behavior in early childhood Open
View article: Longitudinal Changes in Youth Mental Health From Before to During the COVID-19 Pandemic
Longitudinal Changes in Youth Mental Health From Before to During the COVID-19 Pandemic Open
Importance Robust longitudinal studies of within-child changes in mental health associated with the COVID-19 pandemic are lacking, as are studies examining sources of heterogeneity in such changes. Objective To investigate within-child cha…
View article: Association of prenatal vitamin E levels with child asthma and wheeze
Association of prenatal vitamin E levels with child asthma and wheeze Open
Background We investigated the individual and interaction effects of maternal plasma 𝛂‐ and ϒ‐tocopherol levels (vitamin E isomers) on child asthma and wheeze at age 8–9. Methods Mother–child dyads were enrolled between 2006 and 2011 into …
View article: Early life ambient ozone exposure and the development of asthma and wheeze in children
Early life ambient ozone exposure and the development of asthma and wheeze in children Open
View article: Prenatal air pollution exposure and risk of autism: findings from ECHO cohorts
Prenatal air pollution exposure and risk of autism: findings from ECHO cohorts Open
View article: Patterns of Pediatric Chronic Health Outcomes in the United States: The Environmental Influences on Child Health Outcomes (ECHO) Program
Patterns of Pediatric Chronic Health Outcomes in the United States: The Environmental Influences on Child Health Outcomes (ECHO) Program Open
View article: Poverty and neighborhood opportunity effects on neonate DNAm developmental age
Poverty and neighborhood opportunity effects on neonate DNAm developmental age Open
Background Children from families with low socioeconomic status (SES), as determined by income, experience several negative outcomes, such as higher rates of newborn mortality and behavioral issues. Moreover, associations between DNA methy…
View article: Urinary polycyclic aromatic hydrocarbon (PAH) metabolite concentrations in three pregnancy cohorts from 7 U.S. study sites
Urinary polycyclic aromatic hydrocarbon (PAH) metabolite concentrations in three pregnancy cohorts from 7 U.S. study sites Open
Objective Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with adverse birth and developmental outcomes in children. We aimed to describe prenatal PAH exposures in a large, multisite U.S. consortium. Methods We m…
View article: Associations Between Prenatal Vitamin D and Placental Gene Expression
Associations Between Prenatal Vitamin D and Placental Gene Expression Open
View article: Measurement bias in caregiver-report of early childhood behavior problems across demographic factors in an ECHO-wide diverse sample
Measurement bias in caregiver-report of early childhood behavior problems across demographic factors in an ECHO-wide diverse sample Open
Background: Research and clinical practice rely heavily on caregiver-report measures, such as the Child Behavior Checklist 1.5-5 (CBCL/1.5-5), to gather information about early childhood behavior problems and to screen for child psychopath…
View article: A genome scale transcriptional regulatory model of the human placenta
A genome scale transcriptional regulatory model of the human placenta Open
Gene regulation is essential to placental function and fetal development. We built a genome-scale transcriptional regulatory network (TRN) of the human placenta using digital genomic footprinting and transcriptomic data. We integrated 475 …
View article: Prenatal exposure to polycyclic aromatic hydrocarbons and executive functions at school age: Results from a combined cohort study
Prenatal exposure to polycyclic aromatic hydrocarbons and executive functions at school age: Results from a combined cohort study Open
We conducted a novel exploration of PAH-executive functions association in a large, combined sample from two cohorts. Although findings were predominantly null, the study carries important implications for future research and contributes t…
View article: Associations Between Prenatal Vitamin D and Placental Gene Expression
Associations Between Prenatal Vitamin D and Placental Gene Expression Open
Background Vitamin D is a hormone regulating gene transcription. Prenatal vitamin D has been linked to immune and vascular function in the placenta, a key organ of pregnancy. To date, studies of vitamin D and placental gene expression have…
View article: Green Space and Internalizing or Externalizing Symptoms Among Children
Green Space and Internalizing or Externalizing Symptoms Among Children Open
Importance Evidence suggests that living near green space supports mental health, but studies examining the association of green space with early mental health symptoms among children are rare. Objective To evaluate the association between…