Kalpana Patel
YOU?
Author Swipe
View article: Diagnostic difficulty in an adolescent with dissociative identity disorder
Diagnostic difficulty in an adolescent with dissociative identity disorder Open
Introduction: Dissociative identity disorder (DID) is a complex and controversial psychiatric condition characterised by the presence of two or more distinct identities, personality states, or identities that recurrently take control of an…
View article: Spatial intra-tumour heterogeneity and treatment-induced genomic evolution in oesophageal adenocarcinoma: implications for prognosis and therapy
Spatial intra-tumour heterogeneity and treatment-induced genomic evolution in oesophageal adenocarcinoma: implications for prognosis and therapy Open
Background Oesophageal adenocarcinoma (OAC) is a highly heterogeneous cancer with poor survival. Standard curative treatment is chemotherapy with or without radiotherapy followed by oesophagectomy. Genomic heterogeneity is a feature of OAC…
View article: The oesophageal adenocarcinoma tumour immune microenvironment dictates outcomes with different modalities of neoadjuvant therapy – results from the AGITG DOCTOR trial and the cancer evolution biobank
The oesophageal adenocarcinoma tumour immune microenvironment dictates outcomes with different modalities of neoadjuvant therapy – results from the AGITG DOCTOR trial and the cancer evolution biobank Open
A plateau in treatment effect can be seen for the current ‘one-size-fits-all’ approach to oesophageal adenocarcinoma (OAC) management using neoadjuvant chemoradiotherapy (nCRT) or chemotherapy (nCT). In OAC, the tumour microenvironment (TM…
View article: Circulating Tumor DNA
Circulating Tumor DNA Open
View article: C‐reactive protein is a prognostic biomarker in pancreatic ductal adenocarcinoma patients
C‐reactive protein is a prognostic biomarker in pancreatic ductal adenocarcinoma patients Open
Aim The 5‐year survival rate of pancreatic ductal adenocarcinoma (PDAC) is approximately 11% and has only improved marginally over the last three decades. For operable PDAC, resection and adjuvant FOLFIRINOX chemotherapy is standard of car…
View article: Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy
Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy Open
Oesophageal adenocarcinoma is a poor prognosis cancer and the molecular features underpinning response to treatment remain unclear. We investigate whole genome, transcriptomic and methylation data from 115 oesophageal adenocarcinoma patien…
View article: Radiomics biomarkers are associated with survival in patients with Oesophageal Adenocarcinoma
Radiomics biomarkers are associated with survival in patients with Oesophageal Adenocarcinoma Open
Objective: Radiomics studies have shown promising results defining image surrogates that predict treatment response and survival in oesophageal squamous cell carcinoma. There are limited studies examining radiogenomics profiles in oesophag…
View article: 280. MULTI-OMIC FEATURES OF OESOPHAGEAL ADENOCARCINOMA PATIENTS PRE-TREATED WITH PREOPERATIVE NEOADJUVANT THERAPY
280. MULTI-OMIC FEATURES OF OESOPHAGEAL ADENOCARCINOMA PATIENTS PRE-TREATED WITH PREOPERATIVE NEOADJUVANT THERAPY Open
The incidence of oesophageal adenocarcinoma (OAC) is rising in Western countries, with a 5-year overall survival (OS) rate of 14%. Curative treatment based on oesophagectomy is only suitable for ~50% of patients due to late-stage diagnosis…
View article: Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels
Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels Open
View article: Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid‐induced DNA damage
Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid‐induced DNA damage Open
Background The risk of esophageal adenocarcinoma (EAC) is associated with gastro‐esophageal reflux disease (GERD) and obesity. Lipid metabolism‐targeted therapies decrease the risk of progressing from Barrett's esophagus (BE) to EAC, but t…
View article: ctDNA as a biomarker of progression in oesophageal adenocarcinoma
ctDNA as a biomarker of progression in oesophageal adenocarcinoma Open
This study demonstrates that ctDNA variants can be detected in patients with OAC and this has potential clinical utility as a prognostic biomarker for survival.
View article: Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
Treatment for metastatic melanoma includes targeted and/or immunotherapy. Although many patients respond, only a subset has complete response. As late-stage patients often have multiple tumors in difficult access sites, non-invasive techni…
View article: Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients
Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients Open
Patients with late stage resected cutaneous melanoma have poor overall survival (OS) and experience irreversible adverse events from systemic therapy. There is a clinical need to identify biomarkers to predict outcome. Performing germline/…
View article: 038 Examining the Effects of ErbB4 Deletion on Cardiomyocytes and Cardiac Endothelium in Neonatal Mice
038 Examining the Effects of ErbB4 Deletion on Cardiomyocytes and Cardiac Endothelium in Neonatal Mice Open
View article: Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study
Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study Open
Bioinformatic analyses and cellular and zebrafish gene expression studies implicate NAPRT1 as a novel susceptibility gene. Given this gene's role in niacin metabolism and the evidence for niacin deficiency provoking schizophrenialike sympt…
View article: Complex structural rearrangements are present in high-grade dysplastic Barrett’s oesophagus samples
Complex structural rearrangements are present in high-grade dysplastic Barrett’s oesophagus samples Open
The presence of complex localised rearrangements in dysplastic samples indicates a need for further investigations into the role such events play in the progression from BE to EAC.
View article: Additional file 2: of Complex structural rearrangements are present in high-grade dysplastic Barrettâ s oesophagus samples
Additional file 2: of Complex structural rearrangements are present in high-grade dysplastic Barrettâ s oesophagus samples Open
Table S1a. Clinical information for 22 EAC samples. Table S1b. Clinical information for 16 BE samples. Table S1c. WGS coverage metrics and order of samples for Figs. 1, 2 and 3. (XLSX 17 kb)
View article: Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques
Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques Open
Pathogenic human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection of humans and rhesus macaques (RMs) induces persistently high production of type I interferon (IFN-I), which is thought to contribute to disease pr…
View article: Differences in expression of gut-homing receptors on CD4+ T cells in black and white HIV-negative men who have sex with men
Differences in expression of gut-homing receptors on CD4+ T cells in black and white HIV-negative men who have sex with men Open
HIV incidence rates are higher among black men who have sex with men (BMSM) as compared with MSM of other race/ethnicities in the USA. We found that blood memory CD4 cells from BMSM express higher levels of α4β7, the gut-homing integrin, c…
View article: Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma
Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma Open
The incidence of esophageal adenocarcinoma (EAC) has risen significantly over recent decades. Although survival has improved, cure rates remain poor, with <20% of patients surviving 5 years. This is the first study to explore methylome, tr…
View article: C-77Minnesota Multiphasic Personality Inventory-2-Restructured Format Profiles in Malingered Attention Deficit Hyperactivity Disorder: Does Reason for Malingering Matter?
C-77Minnesota Multiphasic Personality Inventory-2-Restructured Format Profiles in Malingered Attention Deficit Hyperactivity Disorder: Does Reason for Malingering Matter? Open
Objective: There is growing awareness of need to assess for malingering in adult referrals for Attention Deficit Hyperactivity Disorder (ADHD).As much of ADHD diagnosis is based on self-report, it is imperative to examine accuracy of self-…