Explanipedia

AI Act Demands for Responsible Innovation: Where to go From Here? Open

Roosmarie Jessen, Kak Khee Yeung, M.C. Ploem · 2025

Role of Epidural Anaesthesia in Elective Open Abdominal Aortic Aneurysm Repair: Secondary Analysis of a Randomised Trial Open

T A H Steunenberg, Susanne Eberl, Arno M. Wiersema, Liliane C. Roosendaal, Max Hoebink , et al. · 2025

PEA was found to be associated with fewer bleeding complications, reduced extreme pain, better mobility, and improved HRQoL one week post-operatively.

Vessel-on-Chip model of the microcirculation in Abdominal aortic aneurysms Open

Philipp Christoph Hauger, Karlijn B. Rombouts, Marc Vila Cuenca, Albert C.W.A. van Wijk, Max C. Overboom , et al. · 2025

Abdominal aortic aneurysms (AAA) are pathological dilations of the abdominal aorta. To date, surgical intervention is the only option for managing large AAAs, with no pharmacological therapies to prevent growth of small aneurysms. A curren…

Aortic hemorrhage following anastomotic leakage after esophagogastric surgery before and after implementation of endoscopic vacuum therapy Open

Lisanne Pattynama, Roos E. Pouw, Berrie Meijer, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz , et al. · 2025

Background Endoscopic vacuum therapy (EVT) has been established as a safe and effective treatment for anastomotic leakage. While rare, major aortic hemorrhage has been reported as a severe complication potentially associated with EVT. Howe…

Proteome Differences in Smooth Muscle Cells from Diabetic and Non-Diabetic Abdominal Aortic Aneurysm Patients Reveal Metformin-Induced Mechanisms Open

Tara A. R. van Merrienboer, Karlijn B. Rombouts, Albert C.W.A. van Wijk, Jaco C. Knol, Thang V. Pham , et al. · 2025

Aims: Surgery remains the only definitive treatment option for abdominal aortic aneurysms (AAA), as no conclusive evidence supports drug effectiveness in preventing AAA growth. Although type 2 diabetes (T2D) is an important cardiovascular …

A Core Outcome Set for Patients with Chronic Symptomatic Peripheral Arterial Disease Open

Sabrina L M Zwetsloot, Lotte Rijken, Igor Končar, Ivan Tomić, Marina Dias‐Neto , et al. · 2025

This is the first COS for patients with chronic symptomatic PAD recommended for adoption in clinical and AI research.

International Expert Consensus on the Management of Acute Aortic Type B Intramural Haematoma and Penetrating Ulcer Open

Francesco Squizzato, Mario D’Oria, Michele Antonello, Santi Trimarchi, Kevin Mani , et al. · 2025

An agreement among international experts was achieved on assessment, management, and follow up of acute type B IMHs and PAUs, addressing areas of inconsistencies or knowledge gaps in existing guidelines.

Exploring diversity and inclusion in surgery: Insights from the 2025 Dutch Surgical Society Symposium Open

Begüm Pekbay, Hajar Rotbi, Michael El Boghdady, Joanna W. A. M. Bosmans, Joris J. Blok , et al. · 2025

Diversity and inclusion are increasingly recognized as critical components of effective surgical practice and team dynamics. Despite growing awareness, structural barriers continue to limit the entry and advancement of individuals from und…

The development of a data dictionary with clinical variables for artificial intelligence-driven tools in research on abdominal aortic aneurysms and peripheral arterial disease Open

Lotte Rijken, Sabrina L M Zwetsloot, Carsten Müller, Marlies P. Schijven, Vincent Jongkind , et al. · 2025

Aims Patients with abdominal aortic aneurysms and peripheral arterial disease (arterial vascular diseases) carry a high disease burden and are likely to experience cardiovascular events. Novel strategies using artificial intelligence could…

Validation of the E-CABG Bleeding Severity Classification in Open Peripheral Arterial Surgery Open

T A H Steunenberg, J P Hakbijl, Liliane C. Roosendaal, Arno M. Wiersema, Kak Khee Yeung , et al. · 2025

The E-CABG bleeding classification is applicable for stratifying the severity of perioperative bleeding in OPAS and predicting adverse short-term postoperative outcomes for research and registry databases.

Identification of Clinical and Patient Reported Outcomes for Patients with Intact Abdominal Aortic Aneurysms Not Undergoing Repair: A Systematic Review Open

Sabrina L M Zwetsloot, Samira Elize Mariko van Knippenberg, Venkat Ayyalasomayajula, Kak Khee Yeung, Vincent Jongkind · 2025

The definitive 77 item AAA outcome longlist will be used in a Delphi study to create a COS for research on intact AAA not undergoing repair.

From European Standards to Responsible Use of AI in Clinical Practice Open

Roosmarie Jessen, Marieke Bak, Carola Müller, Helena M. Verkooijen, Kak Khee Yeung , et al. · 2025

This contribution explores the implications of the EU legal framework for the use of AI in health care, with a focus on the EU Artificial Intelligence Act. The AI Act, currently the most specific legal AI document, is not tailored to healt…

Efficacy and Safety of Tranexamic Acid in Noncardiac Arterial Procedures: A Systematic Review and Meta-Analysis Open

T A H Steunenberg, N. Bakker, Arno M. Wiersema, E. Tournoij, Kak Khee Yeung , et al. · 2025

TXA does not increase the risk of TEC in NCAP. However, there is currently insufficient evidence that TXA reduces bleeding complications.

Beyond Survival: Assessing Quality of Life, Activity Level, and Ethnic Diversity in Aortic Dissection Survivors Open

Nora Bacour, Olivia van Erp, Simran Grewal, Aytug U. Tirpan, Susanne Eberl , et al. · 2025

Background: An acute aortic dissection (AAD) is a highly lethal condition that demands immediate medical intervention. Survivors often face significant long-term challenges. While immediate survival remains a critical focus in acute care s…

Developing Trustworthy Artificial Intelligence Models to Predict Vascular Disease Progression: the VASCUL-AID-RETRO Study Protocol Open

Lotte Rijken, Sabrina Zwetsloot, Stefan P.M. Smorenburg, Jelmer M. Wolterink, Ivana Išgum , et al. · 2025

Introduction: Abdominal aortic aneurysms (AAAs) and peripheral artery disease (PAD) are two vascular diseases with a significant risk of major adverse cardiovascular events and mortality. A challenge in current disease management is the un…

Multimodal Artificial Intelligence Model for Prediction of Abdominal Aortic Aneurysm Shrinkage After Endovascular Repair ( the ART in EVAR study) Open

R E van Rijswijk, Marko Bogdanovic, Joy Roy, Kak Khee Yeung, Clark J. Zeebregts , et al. · 2025

Purpose: The goal of the study described in this protocol is to build a multimodal artificial intelligence (AI) model to predict abdominal aortic aneurysm (AAA) shrinkage 1 year after endovascular aneurysm repair (EVAR). Methods: In this r…

SIRE: Scale-invariant, rotation-equivariant estimation of artery orientations using graph neural networks Open

Dieuwertje Alblas, Julian Suk, Christoph Brüne, Kak Khee Yeung, Jelmer M. Wolterink · 2025

The orientation of a blood vessel as visualized in 3D medical images is an important descriptor of its geometry that can be used for centerline extraction and subsequent segmentation, labeling, and visualization. Blood vessels appear at mu…

The Impact of Diabetes Mellitus and Metformin Use on Outcomes After Endovascular Aneurysm Repair Open

Tara A. R. van Merrienboer, Veerle Warlich, Suzanne Holewijn, Wouter Driessen, Kak Khee Yeung , et al. · 2025

Objective: To study the influence of diabetes mellitus (DM) and metformin treatment on aneurysm sac remodeling after endovascular aneurysm repair (EVAR). Methods: A retrospective single-center cohort analysis was conducted on consecutive p…

Follow up Imaging Protocols after Endovascular Aneurysm Repair: Results of the International FOREVAR Survey Open

Bich L. Tran, Sabrina L M Zwetsloot, Martin Teraa, Fabien Lareyre, Leszek Kukulski , et al. · 2025

Objective: Endovascular repair for aortic aneurysms necessitates routine follow up due to potential late complications, such as endograft occlusions, endoleaks, and late aneurysm rupture. Guidelines recommend periodic post-operative imagin…

Long-term Cardiovascular and All-Cause Mortality following Elective Infrarenal Repair of the Abdominal Aortic Aneurysm: A Systematic Review and Meta-analysis Open

Samira Elize Mariko van Knippenberg, Cecilia Fenelli, Susan van Dieren, Ronak Delewi, Ron Balm , et al. · 2024

Background: Patients with abdominal aortic aneurysms (AAAs) have poor survival rates after aneurysm repair compared with the general population, potentially due to increased cardiovascular risk. This systematic review and meta-analysis aim…

NUAK1 regulates contraction in vascular smooth muscle cells derived from abdominal aortic aneurysm patients Open

Karlijn B. Rombouts, Tara A. R. van Merrienboer, Alex A. Henneman, Jaco C. Knol, Thang V. Pham , et al. · 2024

Aim Abdominal aortic aneurysms (AAA) are defined as a dilatation of the aortic wall. Impaired contractile ability of vascular smooth muscle cells (vSMC) is a hallmark of AAA. This study investigates the underlying mechanism of altered in v…

A Core Outcome Set for Small Abdominal Aortic Aneurysms Open

Sabrina L M Zwetsloot, Lotte Rijken, Igor Končar, Marina Dias‐Neto, Regent Lee , et al. · 2024

Background It remains elusive which patients with an abdominal aortic aneurysm (AAA) will experience cardio-vascular disease progression. Current literature on small AAAs is characterized by heterogeneous and selective outcome reporting. A…

Mid-Term Outcomes of the Viabahn Balloon-Expandable Endoprosthesis as Bridging Stent Graft for Fenestrated and Branched Endovascular Aortic Repair Open

Kaj Olav Kappe, Samira Elize Mariko van Knippenberg, Bich L. Tran, Rutger J. Lely, Bram B. van der Meijs , et al. · 2024

Purpose: Bridging stent grafts (BSG) implanted during fenestrated and branched endovascular aortic repair (F/B-EVAR) are crucial for the successful exclusion of thoracoabdominal and complex abdominal aortic aneurysms (AAA). The aim of this…

External Validation of Fully-Automated Infrarenal Maximum Aortic Aneurysm Diameter Measurements in Computed Tomography Angiography Scans Using Artificial Intelligence (PRAEVAorta 2) Open

Johannes Hatzl, Christian Uhl, Alexandru Barb, Daniel J. Henning, Jonathan Fiering , et al. · 2024

Purpose: This study investigates the accuracy of fully-automated maximum aortic diameter measurements in abdominal aortic aneurysm (AAA) patients using artificial intelligence software (PRAEVAorta 2, Nurea, Bordeaux, France). Materials and…

Outcomes of Catheter Directed Thrombolysis for Early and Late Re-occlusions in Acute Lower Limb Ischemia Open

Safae Oukrich, Sabrina A.N. Doelare, Arno M. Wiersema, A.W.J. Hoksbergen, Kak Khee Yeung , et al. · 2024

Purpose: Acute lower limb ischemia (ALI) is a sudden decrease in arterial limb perfusion due to an arterial blockage, threatening limb and life. Catheter-directed thrombolysis (CDT) is a minimally invasive procedure to remove such obstruct…

Catheter-Directed Thrombolysis for (Not Immediately) Threatened Acute Lower Limb Ischemia: Clinical Outcome and Efficacy Open

Sabrina A.N. Doelare, Safae Oukrich, Bich L. Tran, Arno M. Wiersema, Arjan W.J. Hoksbergen , et al. · 2024

Objective: The objective of this study was to examine the short- and midterm outcomes of catheter-directed thrombolysis (CDT) for acute lower limb ischemia (ALI), classes Rutherford 1 and 2, with specific attention to functional outcome. M…

Ability of Activated Clotting Time Measurements to Monitor Unfractionated Heparin Activity During NonCardiac Arterial Procedures Open

Max Hoebink, Thomas A.H. Steunenberg, Liliane C. Roosendaal, Arno M. Wiersema, Henrike M. Hamer , et al. · 2024

Strong correlation and an independent association were observed between heparin activity measured by anti-Xa and ACT using the HMS Plus.

Metformin Improves the Function of Abdominal Aortic Aneurysm Patient-Derived Aortic Smooth Muscle Cells Open

Tara A. R. van Merrienboer, Karlijn B. Rombouts, Natalija Bogunovic, Arnout Mieremet, Jorn P. Meekel , et al. · 2024

This study found that metformin increases contractility and metabolic activity, and reduces proliferation, migration, and inflammation in aortic SMCs in vitro.

Systematic Review of Outcome Reporting for Interventions to Treat Patients with Acute Lower Limb Ischaemia Open

Sabrina Aisha Nahar Doelare, Safae Oukrich, Kak Khee Yeung, Robert J. Hinchliffe, Vincent Jongkind , et al. · 2024

This systematic review provides an overview of currently reported outcomes in the literature of interventions for ALI. After categorisation into agreed outcome terms, 72 outcomes were identified that can be used in the development of a COS.

AAA-100: A Curated Dataset of 3D Watertight Abdominal Aortic Aneurysm Models Open

Patryk Rygiel, Dieuwertje Alblas, Christoph Brüne, Kak Khee Yeung, Jelmer M. Wolterink · 2024

An abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aorta exceeding 30 mm that might rupture, with fatal outcomes in 70-80% of cases. Personalized 3D models of AAAs, including surrounding vasculature such as iliac and…

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