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View article: Accurate positioning of functional residues with robotics-inspired computational protein design
Accurate positioning of functional residues with robotics-inspired computational protein design Open
Significance Computational protein design promises to advance applications in medicine and biotechnology by creating proteins with many new and useful functions. However, new functions require the design of specific and often irregular ato…
View article: Accurately positioning functional residues with robotics-inspired computational protein design
Accurately positioning functional residues with robotics-inspired computational protein design Open
Accurate positioning of functional residues is critical for the design of new protein functions, but has remained difficult because of the prevalence of irregular local geometries in active sites. Here we introduce two computational method…
View article: Wellmap: a file format for microplate layouts
Wellmap: a file format for microplate layouts Open
Objective Microplates are ubiquitous in biological research because they make it easy to collect data for hundreds of different conditions in a single experiment. Despite this, there is no standard method to annotate the wealth of data con…
View article: Computational design of structured loops for new protein functions
Computational design of structured loops for new protein functions Open
The ability to engineer the precise geometries, fine-tuned energetics and subtle dynamics that are characteristic of functional proteins is a major unsolved challenge in the field of computational protein design. In natural proteins, funct…
View article: Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs Open
The CRISPR-Cas9 system provides the ability to edit, repress, activate, or mark any gene (or DNA element) by pairing of a programmable single guide RNA (sgRNA) with a complementary sequence on the DNA target. Here we present a new method f…
View article: Designing functional macromolecules
Designing functional macromolecules Open
Biology is driven by functional macromolecules, most notably proteins and non-coding RNAs. Learning how to design similarly functional macromolecules is a natural goal. Success will not only bring the ability to create new biological syste…