Kaleem Iqbal
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View article: Whole Exome-Wide Association Identifies Rare Variants in APC Associated with High-Risk Colorectal Cancer in the Middle East
Whole Exome-Wide Association Identifies Rare Variants in APC Associated with High-Risk Colorectal Cancer in the Middle East Open
Background: Colorectal cancer (CRC) displays a complex pattern of inheritance. It is postulated that much of the missing heritability of CRC is enriched in high-impact rare alleles, which might play a crucial role in the etiology and susce…
View article: Identification and characterization of ATM founder mutation in BRCA-negative breast cancer patients of Arab ethnicity
Identification and characterization of ATM founder mutation in BRCA-negative breast cancer patients of Arab ethnicity Open
View article: Whole Exome-Wide Association Identifies Rare Variants in GALNT9 Associated with Middle Eastern Papillary Thyroid Carcinoma Risk
Whole Exome-Wide Association Identifies Rare Variants in GALNT9 Associated with Middle Eastern Papillary Thyroid Carcinoma Risk Open
Papillary thyroid carcinoma (PTC) is the commonest thyroid cancer. The majority of inherited causes of PTC remain elusive. However, understanding the genetic underpinnings and origins remains a challenging endeavor. An exome-wide associati…
View article: Identification and Characterization of Atm Founder Germline Mutation in Brca-negative Breast Cancer Patients of Arab Ethnicity
Identification and Characterization of Atm Founder Germline Mutation in Brca-negative Breast Cancer Patients of Arab Ethnicity Open
Background Breast Cancer (BC) is the most prevalent malignancy among women worldwide with germline pathogenic variants/likely pathogenic variants (PVs/LPVs) in BRCA1/2 accounting for a large portion of hereditary cases. Recently, heterozyg…
View article: PALB2 germline mutations in a large cohort of Middle Eastern breast-ovarian cancer patients
PALB2 germline mutations in a large cohort of Middle Eastern breast-ovarian cancer patients Open
The PALB2 gene is a breast cancer (BC) and ovarian cancer (OC) predisposition gene involved in the homologous recombination repair pathway. However, the prevalence and clinicopathological association of PALB2 pathogenic/likely pathogenic (…
View article: X-linked inhibitor of apoptosis protein (XIAP) predicts disease-free survival in BRAFV600E mutant papillary thyroid carcinoma in middle eastern patients
X-linked inhibitor of apoptosis protein (XIAP) predicts disease-free survival in BRAFV600E mutant papillary thyroid carcinoma in middle eastern patients Open
Background X-linked inhibitor of apoptosis (XIAP) is the most potent caspase inhibitory IAP family member and its over-expression is implicated in aggressive behavior of various solid tumors, including papillary thyroid carcinoma (PTC). BR…
View article: Lynch Syndrome Identification in Saudi Cohort of Endometrial Cancer Patients Screened by Universal Approach
Lynch Syndrome Identification in Saudi Cohort of Endometrial Cancer Patients Screened by Universal Approach Open
Lynch syndrome (LS) is the most common cause of inherited endometrial cancer (EC). The prevalence and molecular characteristic of LS in Middle Eastern women with EC have been underexplored. To evaluate the frequency of LS in a cohort of EC…
View article: Exome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer
Exome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer Open
View article: TERT Promoter Mutations Are an Independent Predictor of Distant Metastasis in Middle Eastern Papillary Thyroid Microcarcinoma
TERT Promoter Mutations Are an Independent Predictor of Distant Metastasis in Middle Eastern Papillary Thyroid Microcarcinoma Open
Background Papillary thyroid microcarcinomas (PTMCs) have been attributed to the recent increased incidence of thyroid cancer. Although indolent, a subset of PTMC could potentially develop distant metastasis (DM). This study aimed to evalu…
View article: Prevalence of Lynch Syndrome in Middle Eastern Women with Mismatch Repair Deficient Ovarian Cancer
Prevalence of Lynch Syndrome in Middle Eastern Women with Mismatch Repair Deficient Ovarian Cancer Open
Objective: Microsatellite instability (MSI) is a hallmark of Lynch Syndrome (LS). This study aims to determine the prevalence of LS and the optimal diagnostic method in women from Middle Eastern ethnicity with newly diagnosed epithelial ov…
View article: Prevalence of germline TP53 mutation among early onset middle eastern breast cancer patients
Prevalence of germline TP53 mutation among early onset middle eastern breast cancer patients Open
View article: Recurrent Somatic MAP2K1 Mutations in Papillary Thyroid Cancer and Colorectal Cancer
Recurrent Somatic MAP2K1 Mutations in Papillary Thyroid Cancer and Colorectal Cancer Open
Mitogen-activated protein kinase kinase 1 (MAP2K1) is a dual specificity protein kinase that phosphorylates both threonine and tyrosine residues in ERK . MAP2K1 mutations have been identified in several cancers. However, their role in Midd…
View article: Additional file 1 of Prevalence of germline TP53 mutation among early onset middle eastern breast cancer patients
Additional file 1 of Prevalence of germline TP53 mutation among early onset middle eastern breast cancer patients Open
Additional file 1
View article: Process optimization for the production of Yeast Extract using fresh Baker’s yeast
Process optimization for the production of Yeast Extract using fresh Baker’s yeast Open
Yeast extract is extensively applied in various food industries as a food additive to enhance to flavor of food products or as a vitamin supplement. It is also considered as a crucial component of microbiological media. The current study w…
View article: POLE and POLD1 pathogenic variants in the proofreading domain in papillary thyroid cancer
POLE and POLD1 pathogenic variants in the proofreading domain in papillary thyroid cancer Open
Thyroid cancer is the most frequent endocrine cancer with an increasing incidence rate worldwide and is the second most common malignancy among females in Saudi Arabia. Papillary thyroid cancer (PTC) is the most common subtype. Germline pa…
View article: POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East
POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East Open
Background Colorectal cancer (CRC) is a major contributor to morbidity and mortality related to cancer. Only ~5% of all CRCs occur as a result of pathogenic variants in well‐defined CRC predisposing genes. The frequency and effect of exonu…
View article: Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region
Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region Open
View article: Telomerase reverse transcriptase promoter mutations in cancers derived from multiple organ sites among middle eastern population
Telomerase reverse transcriptase promoter mutations in cancers derived from multiple organ sites among middle eastern population Open
Sanger Sequencing and immunohistochemistry was employed to investigate the TERT promoter mutations and TERT protein expression with their association to clinicopathological characteristics in over 2200 samples of Middle Eastern origin from…
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Issue Information Open
View article: Prevalence, spectrum, and founder effect of <i>BRCA1</i> and <i>BRCA2</i> mutations in epithelial ovarian cancer from the Middle East
Prevalence, spectrum, and founder effect of <i>BRCA1</i> and <i>BRCA2</i> mutations in epithelial ovarian cancer from the Middle East Open
Germline mutations in breast cancer susceptibility gene 1 and 2 have previously been estimated to contribute to 13-18% of all epithelial ovarian cancer (EOC). To characterize the prevalence and effect of BRCA1 and BRCA2 mutations in Middle…
View article: MOESM1 of Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region
MOESM1 of Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region Open
Additional file 1: Table S1. Functional analysis of POLE and POLD1 genes using Gene Ontology (GO).
View article: FSH and LH secretion from in-vitro cultured buffalo anterior pituitary cells following treatment with diethyl-stilbestrol and medroxy-progesterone and their effects on ovarian activity and hematological variables of female rabbits.
FSH and LH secretion from in-vitro cultured buffalo anterior pituitary cells following treatment with diethyl-stilbestrol and medroxy-progesterone and their effects on ovarian activity and hematological variables of female rabbits. Open