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View article: Analysis of 1,25-dihydroxyvitamin D genomic action in human enteroids and colonoids reveals multiple regulatory effects of vitamin D in human intestinal physiology
Analysis of 1,25-dihydroxyvitamin D genomic action in human enteroids and colonoids reveals multiple regulatory effects of vitamin D in human intestinal physiology Open
Introduction The intestine has molecular and functional diversity across the proximal-distal and the crypt-villus axes, so it is imperative to determine the common and compartment-specific molecular actions of vitamin D. However, very litt…
View article: Mechanisms driving fasting-induced protection from genotoxic injury in the small intestine
Mechanisms driving fasting-induced protection from genotoxic injury in the small intestine Open
New findings are 1) DNA damage reduction following a 24-h fast depends on the timing of postfast refeeding in relation to chemotherapy initiation; 2) fasting/refeeding-induced upregulation of mTORC1 activity is not required for early (6 h)…
View article: RNA Seq Gene Lists
RNA Seq Gene Lists Open
Complete lists of genes for all RNA sequencing figures.
View article: RNA Seq Gene Lists
RNA Seq Gene Lists Open
Complete lists of genes for all RNA sequencing figures.
View article: Gene Ontology Analysis
Gene Ontology Analysis Open
Gene ontology analysis was performed on differentially expressed genes, from comparisons in supplemental table 2, using gprofiler. P adj <0.05 was deemed significant.
View article: Gene Ontology Analysis
Gene Ontology Analysis Open
Gene ontology analysis was performed on differentially expressed genes, from comparisons in supplemental table 2, using gprofiler. P adj <0.05 was deemed significant.
View article: Drivers of transcriptional variance in human intestinal epithelial organoids
Drivers of transcriptional variance in human intestinal epithelial organoids Open
Human intestinal epithelial organoids (enteroids and colonoids) are tissue cultures used for understanding the physiology of the human intestinal epithelium. Here, we explored the effect on the transcriptome of common variations in culture…
View article: Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids
Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids Open
Background & Aims Human intestinal epithelial organoids (enteroids and colonoids) are tissue cultures used for understanding the physiology of the intestinal epithelium. Here, we explored the effect on the transcriptome of common variation…
View article: Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis
Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis Open