К. Ray Chaudhuri
YOU?
Author Swipe
Absence of the LRRK2 mutation in Emirati Parkinson’s disease patients in contrast to other Arab populations Open
Background The role of genetic factors in the pathogenesis of Parkinson’s disease (PD) is characterized by heterogeneity in specific genetic variations and their prevalence across different populations and geographic locations. Objective T…
View article: Effects of a Four‐Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial
Effects of a Four‐Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial Open
Background Gut dysbiosis and gut‐brain‐axis involvement in people with Parkinson's disease ( PwP ) support the use of gut‐microbiota‐modulating interventions. Probiotics may help manage constipation in PwP ; however, mechanisms underpinnin…
A Holistic Wellness Prescription for Parkinson's Disease: Evidence‐Based Perspectives and Unmet Needs Open
Background In modern medicine the concept of wellness is often accompanied by various misconceptions arising from several factors, including a lack of clear definitions, the commercialization of wellness, and prevailing biases and stereoty…
Foslevodopa/foscarbidopa (LDp/CDp) in advanced Parkinson’s disease (aPD): demonstration of savings from a societal perspective in the UK Open
When considered from a societal perspective, the use of LDp/CDp in aPD patients inadequately controlled on oral therapy, is associated with a reduction in medium-term healthcare and societal costs vs BMT.
Improvement in Motor Consistency and Stability with Foslevodopa/Foscarbidopa in Advanced Parkinson’s Disease: Post Hoc Analysis of Two Phase 3 Clinical Trials Open
Clinicaltrials.gov ID: NCT04380142, NCT03781167.
View article: Conceptualizing a Personalized Care Pathway for Parkinson’s Disease Using Wearable Sensors in Muslim Patients: The Ramadan Regimen
Conceptualizing a Personalized Care Pathway for Parkinson’s Disease Using Wearable Sensors in Muslim Patients: The Ramadan Regimen Open
Parkinson's disease (PD) affects approximately 2% of individuals over the age of 60. With over two billion Muslims observing Ramadan, individuals with PD encounter specific challenges, such as deteriorating motor skills, sleep disturbances…
Lower Urinary Tract Symptoms Correlation With Motor and Cognitive Function in Patients With Parkinson Disease Open
Purpose: Parkinson disease (PD) is a common, progressive neurodegenerative disease, affecting approximately 1% of the population over 60. The associated morbidity and mortality are increasing at a faster rate than for any other neurologica…
Early parkinson’s disease: levodopa requirements are associated with the striatal DaT-uptake Open
Precision medicine driven by clinical biomarkers is the state-of-art management approach for Parkinson's disease (PD). Whether pattern of striatal dopaminergic deficiency (demonstrated by single-photon emission CT (SPECT) scanning with 123…
View article: Anomalies in effective connectivity explain different hallucination subtypes in Parkinson’s disease psychosis
Anomalies in effective connectivity explain different hallucination subtypes in Parkinson’s disease psychosis Open
Psychosis and visual hallucinations (VH) in Parkinson’s disease (PD) significantly impact patient outcomes, yet underlying neural mechanisms remain unclear, limiting effective treatments. Here, we used dynamic causal modelling (DCM) to lev…
View article: MRI-Guided Focused Ultrasound in Parkinson’s Disease and Essential Tremor: Incisionless but Invasive. A Narrative Review
MRI-Guided Focused Ultrasound in Parkinson’s Disease and Essential Tremor: Incisionless but Invasive. A Narrative Review Open
Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging and promising technology for treating movement disorders, such as essential tremors and tremor-dominant Parkinson’s disease. MRgFUS utilizes advanced ultrasound transduce…
Early thinking palliative care for people with Parkinson's disease: A thematic synthesis based on a systematic mixed-methods review Open
Background Parkinson's disease is a progressive neurodegenerative disorder. Awareness and the evidence supporting the merits of palliative care (PC) approaches to people with Parkinson's disease (PwP) are increasing. Objective This review …
View article: Validation of the International Parkinson and Movement Disorder Society Non‐Motor Symptoms Questionnaire (<scp>MDS</scp>‐<scp>NMS</scp>‐Q)
Validation of the International Parkinson and Movement Disorder Society Non‐Motor Symptoms Questionnaire (<span>MDS</span>‐<span>NMS</span>‐Q) Open
Background The Movement Disorder Society Non‐Motor Rating Scale (MDS‐NMS) assesses severity and frequency of non‐motor symptoms (NMS) in Parkinson's disease (PD) and is rater‐administered. The MDS‐NMS Questionnaire (MDS‐NMS‐Q), developed a…
View article: Polish validation of Parkinson’s Disease non-motor questionnaire and clinical use in real life PD patients
Polish validation of Parkinson’s Disease non-motor questionnaire and clinical use in real life PD patients Open
The Polish version of the NMSQuest is reliable, valid and endorsed by Polish PD patients. Subsequent clinical use shows this to be a useful self- declaration flagging tool for NMS which needs to be captured in clinical visits so that clini…
View article: Conversion between <scp>NMSS</scp> and <scp>MDS</scp>‐<scp>NMS</scp> in Parkinson's Disease
Conversion between <span>NMSS</span> and <span>MDS</span>‐<span>NMS</span> in Parkinson's Disease Open
Background The burden of non‐motor symptoms in Parkinson's disease (PD) can be measured with the Non‐Motor Symptoms Scale (NMSS) and the International Parkinson and Movement Disorder Society Non‐Motor Rating Scale (MDS‐NMS), for which scor…
Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson’s Disease Psychosis Open
Background Cognitive deficits and reduced dopamine transporter (DAT) binding ratio have been reported in Parkinson’s disease psychosis (PDP). However, it remains unclear whether DAT striatal binding ratio (SBR) may contribute to worsening …
Exenatide once a week versus placebo as a potential disease-modifying treatment for people with Parkinson's disease in the UK: a phase 3, multicentre, double-blind, parallel-group, randomised, placebo-controlled trial Open
National Institute for Health and Care Research and Cure Parkinson's.
View article: Wearable devices may aid the recognition of fluctuation-related pain in Parkinson’s disease—An exploratory, cross-sectional analysis of two prospective observational studies
Wearable devices may aid the recognition of fluctuation-related pain in Parkinson’s disease—An exploratory, cross-sectional analysis of two prospective observational studies Open
Fluctuation-related pain (FRP) affects more than one third of people with Parkinson’s disease (PwP, PD) and has a harmful effect on health-related quality of life (HRQoL), but often remains under-reported by patients and neglected by clini…
View article: Pain in Parkinson's disease is impacted by motor complications, anxiety and sleep disturbances
Pain in Parkinson's disease is impacted by motor complications, anxiety and sleep disturbances Open
Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Over two thirds of People with Parkinson's (PwP) live with chronic PD‐related pain, but its successful management remains an unmet need. Unrevealing l…
Test, track, treat using wearable sensors for management of Parkinson’s disease: 12‑month prospective observational United Arab Emirates study using Parkinson’s Kinetograph (EmPark-PKG Study) Open
Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by both motor and non-motor symptoms that necessitate ongoing clinical evaluation and medication adjustments. Home-based wearable sensor monitoring offers a detail…
Challenges of equitable access to device-aided therapies for advanced Parkinson’s Disease in Poland — expert consensus and treatment recommendations Open
Consensus expert opinion is that APD patients in Poland would benefit from additional reimbursement access to these treatment options to improve APD patient care.